产品简要
公司名称 :
Abcepta
产品类型 :
抗体
产品名称 :
切断的LC3A抗体
目录 :
AP1805a
规格 :
0.1毫克
价格 :
235.00美元
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠, 牛
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片
更多信息或购买 :
Abcepta 产品网页
文章摘录数: 4
出版应用/物种/样本/稀释参考文献
  • 免疫组化-石蜡切片; 人类; 1:100; 图 5b
Jacquin E, Leclerc Mercier S, Judon C, Blanchard E, Fraitag S, Florey O. Pharmacological modulators of autophagy activate a parallel noncanonical pathway driving unconventional LC3 lipidation. Autophagy. 2017;13:854-867 pubmed 出版商
Whelan K, Chandramouleeswaran P, Tanaka K, Natsuizaka M, Guha M, Srinivasan S, et al. Autophagy supports generation of cells with high CD44 expression via modulation of oxidative stress and Parkin-mediated mitochondrial clearance. Oncogene. 2017;36:4843-4858 pubmed 出版商
Tavera Mendoza L, Westerling T, Libby E, Marusyk A, Cato L, Cassani R, et al. Vitamin D receptor regulates autophagy in the normal mammary gland and in luminal breast cancer cells. Proc Natl Acad Sci U S A. 2017;114:E2186-E2194 pubmed 出版商
Tazi M, Dakhlallah D, Caution K, Gerber M, Chang S, Khalil H, et al. Elevated Mirc1/Mir17-92 cluster expression negatively regulates autophagy and CFTR (cystic fibrosis transmembrane conductance regulator) function in CF macrophages. Autophagy. 2016;12:2026-2037 pubmed
产品信息
目录代码 :
AP1805a
产品名称 :
切断的LC3A抗体
宿主物种 :
兔
克隆性 :
多克隆
产品类型 :
一抗
规格 :
0.1毫克
标价 :
235.00美元
克隆 :
RB11841
抗体亚型 :
兔IgE
产品描述 :
肽亲和纯化兔多克隆抗体(多克隆抗体)
交叉活性 :
H
背景 :
Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. These proteins are involved in formation of autophagosomal vacuoles (autophagosomes). MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. MAP1LC3a is one of the light chain subunits and can associate with either MAP1A or MAP1B. The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II.
别名 :
MAP1LC3A, microtubule-associated protein 1 light chain 3 alpha, RP11-346K17.1, LC3, LC3A, MAP1ALC3, MAP1BLC3, MAP1 light chain 3-like protein 1; MAP1A/1B light chain 3 A; MAP1A/MAP1B LC3 A; MAP1A/MAP1B light chain 3 A; OTTHUMP00000030698; autophagy-related protein LC3 A; autophagy-related ubiquitin-like modifier LC3 A; microtubule-associated proteins 1A/1B light chain 3; microtubule-associated proteins 1A/1B light chain 3A
免疫原 :
This LC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 22~51 amino acids from the N-terminal region of human LC3 (APG8a).
缓冲液 :
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
浓度 :
0.25毫克/毫升
应用摘要 :
免疫印迹, 免疫组化, E
储存 :
Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles.
更多信息或购买 :
Abcepta 产品网页
公司信息
Abcepta
10320 Camino Santa Fe Suite G
San Diego, CA 92121
sales@abcepta.com
https://www.abcepta.com
(888) 735-7227
公司总部: 美国
作为药明康德公司的子公司，Abgent成立于2001年，已成为世界知名生物试剂产品及服务供应商，全球5强抗体生产商。