抗体

单克隆抗体c-Myc(Clone:9 E 10)

10-10013

100微克

260美元

单克隆

小鼠

nonconjugated

9 E 10

单克隆抗体c-Myc(Clone:9 E 10)

抗体

小鼠

单克隆

未共轭

9 E 10

小鼠IgG1

Kappa

100微克

260美元

c-Myc proto-oncogene encodes nuclear DNA-binding phosphoproteins that are involved in the regulation of gene expression and DNA replication during cell growth and differentiation. Myc encodes a protein of 65 kDa which is expressed in almost all normal and transformed cells. The Myc protein activates transcription as part of a heteromeric complex with Max. Myc protein represses the expression of Ferritin-H, which sequesters intracellular iron, and stimulates the expression of IRP2 (Iron Regulatory Protein-2), which increases the intracellular iron pool. Myc induces transcription of the E2F1, E2F2 and E2F3 genes. Myc-induced S phase and apoptosis requires distinct E2F activities. The induction of specific E2F activities is an essential component in the Myc pathways that control cell proliferation and cell fate decisions.

人类

H

MYC BHLHE39

A synthetic peptide corresponding to amino acids 408-432 (AEEQKLISEEDLLRKRREQLKHKLE) of human c-Myc was used as the immunogen for this antibody.

蛋白质G色谱

PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.

叠氮化钠

0.5毫克/毫升

Western blot analysis: 2-4 µg/ml. Pack of 25 µg is also availabe .

免疫印迹

Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.