抗体

Monoclonal antibody to DR4 (Clone: ABM1B11 )

10-1002

100微克

260美元

单克隆

小鼠

nonconjugated

ABM1B11

免疫印迹, 流式细胞仪

Monoclonal antibody to DR4 (Clone: ABM1B11 )

抗体

小鼠

单克隆

未共轭

ABM1B11

小鼠IgG1

Kappa

100微克

260美元

Death receptor 4 (DR4) or TRAIL-R1, a member of the tumor necrosis factor receptor superfamily, is a cell surface receptor that triggers the apoptotic machinery upon binding to its ligand tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). DR4 is expressed in most of human tissues including spleen, peripheral blood leukocytes, small intestine and thymus. DR4 expression is enhanced by DNA damage whether induced by ionizing radiation or by chemotherapeutic agents. On binding DR4, TRAIL induces cell death via caspase-dependent apoptosis. DR4 mediate oligomeric Abeta induction of extrinsic apoptotic pathways in human microvascular cerebral endothelial cells with activation of both caspase-8 and caspase-9. It is considered a promising molecular target for cancer therapy.

人类

H

TNFRSF10A APO2 DR4 TRAILR1

A partial length recombinant human DR4 protein (amino acids 2-203 was used as an immunogen for this antibody.

蛋白质G色谱

PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.

叠氮化钠

0.5毫克/毫升

Western blot analysis: 2-4 µg/ml, FACS analysis- 0.5-1 µg/10^6 Cells. Pack of 25 µg is also availabe .

流式细胞仪, 免疫印迹

Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.