抗体

Monoclonal Antibody to Caspase-3 (Pro and Active) (Clone: ABM1C12) FITC Conjugated

10-1003-F

100微克

260美元

单克隆

小鼠

异硫氰酸荧光素

ABM1C12

Monoclonal Antibody to Caspase-3 (Pro and Active) (Clone: ABM1C12) FITC Conjugated

抗体

小鼠

单克隆

异硫氰酸荧光素

ABM1C12

小鼠IgG1

Kappa

100微克

260美元

Caspases are a member of the cysteine-aspartic acid protease family. Caspase-3 (31 kDa) is an executionary caspase which directly cleaves and activates poly(ADP-ribose) polymerase (PARP), sterol regulatory element binding proteins (SREBPs) or it can also interact with other caspases like caspase-6, -7 and -9. Increased levels of caspase-3 are involved in Huntington Disease-associated cell death. Caspase-3 is the principal caspase in mediating the cleavage of amyloid-beta 4A precursor protein (APP), which is related with neuronal death in Alzheimer's disease. Like other caspases, caspase-3 is also synthesized as a zymogen procaspase which is activated by specific proteolytic cleavage. High levels of caspase-3 are observed in lung, spleen, heart, liver and kidney, moderate levels in brain and skeletal muscle, and low in testis.

人类

H

Casp3 Cpp32

Full length recombinant Caspase-3 protein was used as the immunogen for this antibody.

蛋白质G色谱

Tris and 0.05% sodium azide. Sodium azide is highly toxic.

叠氮化钠

0.2毫克/毫升

Flowcytometric: 0.5-1µg/10^6 Cells

流式细胞仪

Store the antibody at 4°C, stable for 6 months.