抗体

Monoclonal Antibody to ATF6 (Clone: ABM1A40)

10-1018

100微克

260美元

单克隆

小鼠

nonconjugated

ABM1A40

免疫印迹, 流式细胞仪

Monoclonal Antibody to ATF6 (Clone: ABM1A40)

抗体

小鼠

单克隆

未共轭

ABM1A40

小鼠IgG1

Kappa

100微克

260美元

ATF6, also named as Cyclic AMP-dependent transcription factor ATF-6 alpha is a member of bZIP family, ATF subfamily. ATF6 forms homodimer and heterodimer with ATF6-beta. ATF6 acts by activating specific unfolded protein response target genes during endoplasmic reticulum stress. ATF6 is a ubiquitously expressed transcription factor located at endoplasmic reticulum (ER) membrane. During ER stress an approximately 50 kDa fragment containing the N-terminal cytoplasmic domain is cleaved by proteolysis and is translocated into the nucleus. N-glycosylation may serve as a sensor for ER homeostasis. For the binding of ATF6 to ERSE, ESRE should first bind to another transcription factor called Nuclear Transcription Factor Y (NF-Y). ATF6 could also be involved in activation of transcription by interacting with serum response factor. ATF6 is a 74 kDa protein and is highly expressed in kidney, liver, colon and mammary gland.

人类

H

转录激活因子6

A partial length recombinant ATF6 protein (amino acids 1-400) was used as the immunogen for this antibody.

蛋白质G色谱

PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.

叠氮化钠

0.5毫克/毫升

Western blot analysis: 2-4 µg/ml, FACS: 0.5-1 µg/10^6 cells. Pack of 25 µg is also availabe .

流式细胞仪, 免疫印迹

Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.