抗体

Monoclonal Antibody to Caspase-8 (Clone: ABM14C1) FITC Conjugated

10-1019-F

100微克

260美元

单克隆

小鼠

异硫氰酸荧光素

ABM14C1

Monoclonal Antibody to Caspase-8 (Clone: ABM14C1) FITC Conjugated

抗体

小鼠

单克隆

异硫氰酸荧光素

ABM14C1

小鼠IgG1

100微克

260美元

Apoptosis occurs during normal cellular development and involves dramatic changes in cellular structure. Disruption of apoptosis may contribute to cancer as well as other autoimmune diseases. Caspase family of cysteine proteases has been shown to play a key role in apoptosis. Caspase-8 is a 55 kDa cytosolic protein that is synthesized as an inactive pro-enzyme. Activation of caspase-8 involves a two-step proteolysis: the cleavage of caspase-8 to generate a 43 and a 12 kDa fragment which is further processed to 10 kDa. The p43 is then cleaved to yield p26 and the release of the active site containing p18.The Active/Cleaved Caspase-8 polyclonal antisera recognizes the large and small subunits of active/cleaved caspase-8. Whereas the antisera has a strong preference for active/cleaved caspase-8, in some cell or tissue systems or techniques the antisera may also recognize the proform of caspase-8 as well as intermediate caspase-8 cleavage fragments.

人类

H

Apoptotic cysteine protease, Apoptotic protease Mch-5, FADD-homologous ICE/ced-3-like protease, CE-like apoptotic protease 5

A partial length recombinant protein (a.a 179-385) of Caspase-8 was used as the immunogen for this antibody.

蛋白质G色谱

Tris and 0.05% sodium azide. Sodium azide is highly toxic.

叠氮化钠

0.2毫克/毫升

Flowcytometric: 0.5-1µg/10^6 Cells

流式细胞仪

Store the antibody at 4°C, stable for 6 months.