抗体

NALE™ Monoclonal Antibody to TLR4 (Clone: ABM19C4)

10-30 10-二嗅磷

100微克

260美元

单克隆

小鼠

nonconjugated

ABM19C4

免疫组化, 流式细胞仪

NALE™ Monoclonal Antibody to TLR4 (Clone: ABM19C4)

抗体

小鼠

单克隆

未共轭

ABM19C4

小鼠IgG2b

Kappa

100微克

260美元

TLR4 (Toll-like receptor-4) is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. It primarily mediates cellular signaling induced by Gram negative bacteria. TLR4 is highly specific for LPS and it is associated with CD14, a co-receptor for LPS. The downstream signaling pathway of TLR4 leads to the activation of NF-kappaB through myeloid differentiation protein (MyD88) and IL-1 receptor-associated kinase in various cell types. Keratinocytes express TLR4 at the mRNA and protein levels whereas TLR4 are also present in the normal human epidermis in vivo and their expression is regulated by microbial components. TLR4 is expressed on CD4+ T cells as well, the functional significance of which is unclear.

人类

H

Toll样受体4

A partial length recombinant TLR4 protein (amino acids 45-320) was used as the immunogen for this antibody.

蛋白质G色谱

PBS containing no Azide and low endotoxin (0.1 EU/1ug).

0.5毫克/毫升

Immunohistochemical analysis: 5 µg/ml; FACS analysis: 2-4 µg/10^6

免疫组化, 流式细胞仪

Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.