抗体

NALE™ Monoclonal Antibody to TLR6 (Clone: ABM1B50)

10-3002-NALE

100微克

260美元

单克隆

小鼠

nonconjugated

ABM1B50

免疫印迹, 流式细胞仪

NALE™ Monoclonal Antibody to TLR6 (Clone: ABM1B50)

抗体

小鼠

单克隆

未共轭

ABM1B50

小鼠IgG1

Kappa

100微克

260美元

TLR6 (Toll-Like Receptors 6) is a member of the TLR (Toll-like receptor) family that plays a fundamental role in pathogen recognition and activation of innate immunity. TLR6 forms heterodimers with TLR1 and TLR2, which is the initial step in a cascade of events leading to significant innate immune responses, development of adaptive immunity to pathogens and protection from immune sequelae related to infection with these pathogens. TLR2 in co-operation with TLR6 trigger inflammatory responses via activation of NF-kappaB, which regulates the transcription of inflammatory molecules. TLR6 has emerged as the most potent activator for ZNPs (Zinc Oxide Nanoparticles)-induced inflammatory responses. Upon silencing, TLR6 significantly inhibited the pro-inflammatory cytokine levels, reactive nitrogen species generation and inducible nitric oxide synthase expression.

人类

H

TLR6

A partial length recombinant TLR6 protein (amino acids 280-512) was used as the immunogen for this antibody.

蛋白质G色谱

PBS containing no Azide and low endotoxin (0.1 EU/1ug).

0.5毫克/毫升

Western blot analysis: 2-4 µg/ml; FACS analysis: 0.5-1 µg/10^6 cells

流式细胞仪, 免疫印迹

Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.