抗体

Monoclonal Antibody to NALP3 (Clone: ABM2D48)

10-3018

100微克

260美元

单克隆

小鼠

nonconjugated

ABM2D48

人类, 小鼠

免疫印迹, 免疫组化

Monoclonal Antibody to NALP3 (Clone: ABM2D48)

抗体

小鼠

单克隆

未共轭

ABM2D48

小鼠IgG2b

Kappa

100微克

260美元

NALP3 (NACHT, LRR and PYD domains-containing protein 3), otherwise known as cryopyrin, is a member of the NLR (Nod-like-receptors) family. This is a pyrin-like protein, having N-terminal CARD or pyrin domains needed for homotypic protein protein interaction, an intermediate nucleotide binding self oligomerization NACHT domain and a C-terminal domain containing leucine rich repeats (LRRs). NALP3 is a key component of innate immunity and its expression is restricted to immune cells and chondrocytes. It interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kB signaling, and it plays an important role in the regulation of inflammation, the immune response, and apoptosis.

小鼠, 人类

M, H

NLRP3 C1orf7 CIAS1 NALP3 PYPAF1

A partial length recombinant NALP3 protein (amino acids 150-385) was used as the immunogen for this antibody.

蛋白质G色谱

PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.

叠氮化钠

0.5毫克/毫升

Western blot analysis: 6-8 µg/ml, Immunohistochemical analysis: 5 µg/ml. Pack of 25 µg is also availabe .

免疫组化, 免疫印迹

Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.