产品简要
公司名称 :
Abeomics
产品类型 :
抗体
产品名称 :
NALE™ Monoclonal antibody to Human CD14 (Clone: RPA-M1 ) (No Azide Low Endotoxin)
目录 :
10-4077-NALE
规格 :
100微克
价格 :
120美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
nonconjugated
克隆名称 :
RPA-M1
反应物种 :
人类
应用 :
流式细胞仪
更多信息或购买 :
产品信息
目录代码 :
10-4077-NALE
产品名称 :
NALE™ Monoclonal antibody to Human CD14 (Clone: RPA-M1 ) (No Azide Low Endotoxin)
产品类型 :
抗体
宿主物种 :
小鼠
克隆性 :
单克隆
共轭 :
未共轭
克隆名称 :
RPA-M1
抗体亚型 :
小鼠IgG1
照明链 :
Kappa
规格 :
100微克
标价 :
120美元
产品描述 :
CD14 antigen is a GPI (Glycosyl-Phosphatidylinositol)-linked glycoprotein and has been shown to be critically important in the signaling pathways of TLR (Toll-like receptor). CD14 expression in BC (Bladder Cancer) subpopulation of cancer cells is required for increased cytokine production and increased tumor growth. Furthermore, tumors formed by CD14-high cells are more highly vascularized with higher myeloid cell infiltration. Inflammatory factors produced by CD14-high BC cells recruit and polarize monocytes and macrophages to acquire immune-suppressive characteristics. CD14 is located on the surface of immune response cells in the lungs as well as other organs. Both TLR4 and CD14 genes are codependent with MD2 in their roles as signalers of other mediators in the innate response to pathogens. It has a central role in innate immunity, as it can interact with several ligands, including LPS from gram-negative bacteria, components from gram-positive bacteria, fungi, and viruses. CD14 has also been suspected to be a crucial link between innate and adaptive immunity in response to environmental antigens.
交叉活性 :
人类
物种摘要 :
H
别名 :
CD14
免疫原 :
Human PHA-stimulated PBMC were used as an immunogen for this antibody.
纯度 :
蛋白质G色谱
缓冲液 :
PBS containing No azide, low endotoxin <0.1EU/1ug).
浓度 :
0.5毫克/毫升
用途 :
FACS:0.5-1微克/10^6细胞
应用摘要 :
流式细胞仪
储存 :
Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
更多信息或购买 :
公司信息
Abeomics
9853 Pacific Heights Blvd., Suite D.
San Diego, CA 92121
support@abeomics.com
www.abeomics.com
858-263-4982
公司总部: 美国