抗体

Monoclonal Antibody to CLEC4E (Clone: ABM42C6)

10-4120

100微克

260美元

单克隆

小鼠

nonconjugated

ABM42C6

免疫印迹, 流式细胞仪

Monoclonal Antibody to CLEC4E (Clone: ABM42C6)

抗体

小鼠

单克隆

未共轭

ABM42C6

小鼠IgG1

Kappa

100微克

260美元

CLEC4E (C-type lectin domain family 4, member E), also called as Mincle, is a type II transmembrane C-type lectin receptor that specifically binds to the cord factor TDM (trehalose-6,6-dimycolate), a unique glycolipid of mycobacterial cell-surface components, and activates immune cells to confer adjuvant activity. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. CLEC4E is mainly expressed in myeloid cells, such as macrophages and neutrophils and possesses a single carbohydrate-recognition domain (CRD) in the extracellular region. It is associated with FcRgamma chain, an immunoreceptor tyrosine-based activation motif (ITAM)-containing adaptor, and acts as an activating receptor that senses damaged cells. CLEC4E is also a downstream target of CCAAT/enhancer binding protein (C/EBP), beta (CEBPbeta) and may play a role in inflammation.

人类

H

CLEC4E CLECSF9 MINCLE UNQ218/PRO244

A full length human CLEC4E protein was used as the immunogen for this antibody.

蛋白质G色谱

PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.

叠氮化钠

0.5毫克/毫升

Western blot analysis: 2-4 µg/ml, Flowcytometric analysis: 0.5-1 µg/10^6 cells. Pack of 25 µg is also availabe .

流式细胞仪, 免疫印迹

Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.