抗体

Monoclonal Antibody to E-cadherin (Clone: ABM43F8)

10-7546

100微克

260美元

单克隆

小鼠

nonconjugated

ABM43F8

免疫印迹, 免疫组化

Monoclonal Antibody to E-cadherin (Clone: ABM43F8)

抗体

小鼠

单克隆

未共轭

ABM43F8

小鼠IgG1

Kappa

100微克

260美元

104.238.111.116/Abeomics/abeo_images_2/10-7546/4.jpg

Fig-4 : Western blot analysis of E-cadherin. Anti- E-cadherin antibody (Clone: ABM43F8) was tested at 4 µg/ml on human Intestine lysate.

Epithelial cadherin (E-cadherin) is a calcium dependent cell-cell adhesion glycoprotein. It is associated with gland formation, stratification, and epithelial polarization. Its deregulation affects cell-cell adhesion and results in increased invasiveness of distinct human carcinomas like gastric cancer, malignancy, oral squamous cell carcinoma, Atypical parathyroid adenoma (APA). Loss of function of E-cadherin leads to the disappearance of epithelial characteristics of the cells and generates higher invasiveness for extracellular matrices. E-cadherin expression is considered to be a decisive indicator for differentiation, aggressive behaviour, high proliferation, metastasis, poor prognosis and invasiveness of human carcinoma cells.

人类

H

CDH1 CDHE UVO

A partial length recombinant E-cadherin protein (amino acids 438-556) was used as the immunogen for this antibody .

蛋白质G色谱

PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.

叠氮化钠

0.5毫克/毫升

Western blot analysis: 4-6 µg/ml, Immunohistochemical analysis: 5-15 µg/ml. Pack of 25 µg is also availabe .

免疫组化, 免疫印迹

Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.