产品简要
公司名称 :
Abeomics
产品类型 :
抗体
产品名称 :
多克隆抗体CADM1
目录 :
11-4037
规格 :
100微克
价格 :
240美元
克隆性 :
多克隆
宿主 :
共轭标签 :
nonconjugated
反应物种 :
人类
应用 :
免疫印迹
更多信息或购买 :
产品信息
目录代码 :
11-4037
产品名称 :
多克隆抗体CADM1
产品类型 :
抗体
宿主物种 :
克隆性 :
多克隆
共轭 :
未共轭
抗体亚型 :
兔IgG
规格 :
100微克
标价 :
240美元
产品描述 :
Cell Adhesion Molecule 1 (CADM1) encodes a multifunctional immunoglobulin-like cell adhesion molecule whose cytoplasmic domain contains a type II PSD95/Dlg/ZO-1 (PDZ)-binding motif (BM) for associating with other intracellular proteins. CADM1 lacks expression in T lymphocytes of healthy individuals and is overexpressed in adult T-cell leukemia-lymphoma (ATL) cells. CADM1 generates a membrane-associated C-terminal fragment, AlphaCTF, through A disintegrin- and metalloprotease-10-mediated ectodomain shedding, subsequently releasing the intracellular domain (ICD) through gamma-secretase-mediated intramembrane shedding of alphaCTF. alphaCTF localizes to mitochondria and induces apoptosis in lung epithelial cells. In women with multiple cervical biopsies, CADM1/MAL methylation increases with severity of the lesion and is lesion-specific. CADM1/MAL methylation status in cervical scrapes appears to be representative of the worst underlying lesion, particularly for CIN3 and cervical cancer.
交叉活性 :
人类
物种摘要 :
H
别名 :
CADM1 IGSF4 IGSF4A NECL2 SYNCAM TSLC1
免疫原 :
A partial length recombinant CADM1 protein (amino acids 50-250) was used as the immunogen for this antibody.
纯度 :
蛋白质A色谱
缓冲液 :
PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
防腐剂 :
叠氮化钠
浓度 :
0.5毫克/毫升
用途 :
Western blot analysis: 2-4 µg/ml. Pack of 25 µg is also availabe .
应用摘要 :
免疫印迹
储存 :
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
更多信息或购买 :
公司信息
Abeomics
9853 Pacific Heights Blvd., Suite D.
San Diego, CA 92121
support@abeomics.com
www.abeomics.com
858-263-4982
公司总部: 美国