抗体

Polyclonal Antibody to TRK Fused gene

11-8031

100微克

240美元

多克隆

兔

nonconjugated

免疫印迹, 免疫组化

Polyclonal Antibody to TRK Fused gene

抗体

兔

多克隆

未共轭

兔IgG

100微克

240美元

TRK Fused gene (TFG) encodes a protein that plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules. It is a conserved regulator of protein secretion that assembles into an oligomeric matrix at the interface between the ER and ER Golgi intermediate compartments in metazoans cells. Originally TFG was identified as a fusion partner of the NTRK1 gene in human papillary thyroid carcinoma. It is also involved in another chromosome translocation with the ALK gene in anaplastic large-cell lymphomas. It is located on the q arm of human chromosome 3 and encodes a ubiquitously expressed cytoplasmic protein. Structural analysis reveals TFG containing a coiled-coil (CC) domain and a serine, proline, tyrosine, glycine and glutamine (SPYGQ)-rich region. Interestingly, the TFG protein interacts with the NF-kappaB essential modulator and TRAF family member-associated NF-kappaB activator proteins, suggesting that it may play a key role in NF-kappaB regulation.

人类

H

TFG

A partial length recombinant TRK Fused gene protein (amino acids 196-400) was used as the immunogen for this antibody.

蛋白质A色谱

PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.

叠氮化钠

0.5毫克/毫升

Western blot analysis:1-2 µg/ml, Immunohistochemical analysis: 20 µg/ml. Pack of 25 µg is also availabe .

免疫组化, 免疫印迹

Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.