产品简要
公司名称 :
亚诺法生技股份有限公司
产品类型 :
抗体
产品名称 :
YAP1单克隆抗体(M01), 克隆2F12
目录 :
H00010413-M01
规格 :
100微克
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
2F12
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片, 免疫组化-冰冻切片
文章摘录数: 18
出版应用/物种/样本/稀释参考文献
  • 免疫组化; 小鼠; 1:100; 图 5a
Korotkevich E, Niwayama R, Courtois A, Friese S, Berger N, Buchholz F, et al. The Apical Domain Is Required and Sufficient for the First Lineage Segregation in the Mouse Embryo. Dev Cell. 2017;40:235-247.e7 pubmed 出版商
  • 免疫细胞化学; 人类; 1:100; 图 3a
Lee H, Diaz M, Price K, Ozuna J, Zhang S, Sevick Muraca E, et al. Fluid shear stress activates YAP1 to promote cancer cell motility. Nat Commun. 2017;8:14122 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:60; 图 s3a
  • 免疫印迹; 小鼠; 1:500; 图 3b
Hirai M, Arita Y, McGlade C, Lee K, Chen J, Evans S. Adaptor proteins NUMB and NUMBL promote cell cycle withdrawal by targeting ERBB2 for degradation. J Clin Invest. 2017;127:569-582 pubmed 出版商
  • 免疫印迹; 大鼠; 1:400; 图 3b
  • 免疫印迹; 人类; 1:400; 图 10a
Simile M, Latte G, Demartis M, Brozzetti S, Calvisi D, Porcu A, et al. Post-translational deregulation of YAP1 is genetically controlled in rat liver cancer and determines the fate and stem-like behavior of the human disease. Oncotarget. 2016;7:49194-49216 pubmed 出版商
  • 免疫沉淀; 人类; 图 5d
Yang S, Zhang L, Purohit V, Shukla S, Chen X, Yu F, et al. Active YAP promotes pancreatic cancer cell motility, invasion and tumorigenesis in a mitotic phosphorylation-dependent manner through LPAR3. Oncotarget. 2015;6:36019-31 pubmed 出版商
  • 免疫沉淀; 人类; 图 1
Yang S, Zhang L, Chen X, Chen Y, Dong J. Oncoprotein YAP regulates the spindle checkpoint activation in a mitotic phosphorylation-dependent manner through up-regulation of BubR1. J Biol Chem. 2015;290:6191-202 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:100
Shao D, Zhai P, Del Re D, Sciarretta S, Yabuta N, Nojima H, et al. A functional interaction between Hippo-YAP signalling and FoxO1 mediates the oxidative stress response. Nat Commun. 2014;5:3315 pubmed 出版商
Lane B, Heller B, Hollenberg M, Wells C. The RGS-RhoGEFs control the amplitude of YAP1 activation by serum. Sci Rep. 2021;11:2348 pubmed 出版商
Bora Singhal N, Mohankumar D, Saha B, Colin C, Lee J, Martin M, et al. Novel HDAC11 inhibitors suppress lung adenocarcinoma stem cell self-renewal and overcome drug resistance by suppressing Sox2. Sci Rep. 2020;10:4722 pubmed 出版商
Maître J, Turlier H, Illukkumbura R, Eismann B, Niwayama R, Nedelec F, et al. Asymmetric division of contractile domains couples cell positioning and fate specification. Nature. 2016;536:344-348 pubmed 出版商
Yang S, Zhang L, Liu M, Chong R, Ding S, Chen Y, et al. CDK1 phosphorylation of YAP promotes mitotic defects and cell motility and is essential for neoplastic transformation. Cancer Res. 2013;73:6722-33 pubmed 出版商
Hirate Y, Cockburn K, Rossant J, Sasaki H. Tead4 is constitutively nuclear, while nuclear vs. cytoplasmic Yap distribution is regulated in preimplantation mouse embryos. Proc Natl Acad Sci U S A. 2012;109:E3389-90; author reply E3391-2 pubmed 出版商
Skouloudaki K, Walz G. YAP1 recruits c-Abl to protect angiomotin-like 1 from Nedd4-mediated degradation. PLoS ONE. 2012;7:e35735 pubmed 出版商
Wada K, Itoga K, Okano T, Yonemura S, Sasaki H. Hippo pathway regulation by cell morphology and stress fibers. Development. 2011;138:3907-14 pubmed 出版商
Sekido Y. Inactivation of Merlin in malignant mesothelioma cells and the Hippo signaling cascade dysregulation. Pathol Int. 2011;61:331-44 pubmed 出版商
Leivonen S, Rokka A, Östling P, Kohonen P, Corthals G, Kallioniemi O, et al. Identification of miR-193b targets in breast cancer cells and systems biological analysis of their functional impact. Mol Cell Proteomics. 2011;10:M110.005322 pubmed 出版商
Murakami H, Mizuno T, Taniguchi T, Fujii M, Ishiguro F, Fukui T, et al. LATS2 is a tumor suppressor gene of malignant mesothelioma. Cancer Res. 2011;71:873-83 pubmed 出版商
Lau Y, Murray L, Houshmandi S, Xu Y, Gutmann D, Yu Q. Merlin is a potent inhibitor of glioma growth. Cancer Res. 2008;68:5733-42 pubmed 出版商
产品信息
目录号码 :
H00010413-M01
产品名称 :
YAP1单克隆抗体(M01), 克隆2F12
产品描述 :
Mouse monoclonal antibody raised against a partial recombinant YAP1.
克隆名称 :
2F12
抗体亚型 :
IgG2a Kappa
基因名称 :
YAP1
基因别名 :
YAP YAP2 YAP65 YKI
基因描述 :
Yes-associated protein 1, 65kDa
GenBank登录号 :
NM_006106
免疫原 :
YAP1 (NP_006097, 53 a.a. ~ 161 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
免疫原序列蛋白序列 :
QIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRKL
PDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPA
SLQLGAVSPGTLTPTGVVSGPAATPTAQHLR
蛋白登录号 :
NP_006097
储存缓冲液 :
在1x PBS, pH值7.4
储存说明 :
储存在-20℃或更低。分装以避免反复冻融
质量控制试验 :
抗体能识别重组蛋白
类型克隆性 :
抗体
宿主物种 :
小鼠
抗原物种靶物种 :
人类
物种活性交叉活性 :
人类, 小鼠
应用 :
WB-Tr,WB-Ce,ELISA,WB-Re,IF,IHC-P
规格 :
100微克
开始日期 :
10/10/06
更新日期 :
11/15/13 18:29
公司信息
亚诺法生技股份有限公司
台湾台北市內湖區洲子街108號9樓
sales@abnova.com
https://www.abnova.com
886-2-87511888