产品简要
公司名称 :
亚诺法生技股份有限公司
产品类型 :
抗体
产品名称 :
TARDBP单克隆抗体(M01), 克隆2E2-D3
目录 :
H00023435-M01
规格 :
100微克
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
2E2-D3
反应物种 :
人类, 小鼠, fruit fly
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片
文章摘录数: 106
出版应用/物种/样本/稀释参考文献
  • 免疫细胞化学; 人类; 1:500; 图 3
Watanabe R, Higashi S, Nonaka T, Kawakami I, Oshima K, Niizato K, et al. Intracellular dynamics of Ataxin-2 in the human brains with normal and frontotemporal lobar degeneration with TDP-43 inclusions. Acta Neuropathol Commun. 2020;8:176 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4a
Zhao T, Hong Y, Yin P, Li S, Li X. Differential HspBP1 expression accounts for the greater vulnerability of neurons than astrocytes to misfolded proteins. Proc Natl Acad Sci U S A. 2017;114:E7803-E7811 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:500; 图 3a
van der Zee J, Gijselinck I, Van Mossevelde S, Perrone F, Dillen L, Heeman B, et al. TBK1 Mutation Spectrum in an Extended European Patient Cohort with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis. Hum Mutat. 2017;38:297-309 pubmed 出版商
  • 免疫组化; fruit fly ; 1:500; 图 7g
Matsukawa K, Hashimoto T, Matsumoto T, Ihara R, Chihara T, Miura M, et al. Familial Amyotrophic Lateral Sclerosis-linked Mutations in Profilin 1 Exacerbate TDP-43-induced Degeneration in the Retina of Drosophila melanogaster through an Increase in the Cytoplasmic Localization of TDP-43. J Biol Chem. 2016;291:23464-23476 pubmed
  • 免疫组化-石蜡切片; 人类; 1:500
Gelpi E, Hoftberger R, Graus F, Ling H, Holton J, Dawson T, et al. Neuropathological criteria of anti-IgLON5-related tauopathy. Acta Neuropathol. 2016;132:531-43 pubmed 出版商
  • 免疫细胞化学; 人类; 图 5
  • 免疫印迹; 人类; 图 2a
De Marco G, Lomartire A, Calvo A, Risso A, De Luca E, Mostert M, et al. Monocytes of patients with amyotrophic lateral sclerosis linked to gene mutations display altered TDP-43 subcellular distribution. Neuropathol Appl Neurobiol. 2017;43:133-153 pubmed 出版商
  • 免疫印迹; 小鼠; 图 3c
Williams K, Topp S, Yang S, Smith B, Fifita J, Warraich S, et al. CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia. Nat Commun. 2016;7:11253 pubmed 出版商
  • 免疫细胞化学; 人类; 1:1000
  • 免疫印迹; 人类; 1:2000
Hans F, Fiesel F, Strong J, J ckel S, Rasse T, Geisler S, et al. UBE2E ubiquitin-conjugating enzymes and ubiquitin isopeptidase Y regulate TDP-43 protein ubiquitination. J Biol Chem. 2014;289:19164-79 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:100; 图 5
Lu T, Aron L, Zullo J, Pan Y, Kim H, Chen Y, et al. REST and stress resistance in ageing and Alzheimer's disease. Nature. 2014;507:448-54 pubmed 出版商
  • 免疫印迹; 人类; 图 1
De Marco G, Lomartire A, Mandili G, Lupino E, Buccinnà B, Ramondetti C, et al. Reduced cellular Ca(2+) availability enhances TDP-43 cleavage by apoptotic caspases. Biochim Biophys Acta. 2014;1843:725-34 pubmed 出版商
  • 免疫组化; 人类
  • 免疫印迹; 人类
Fiesel F, Voigt A, Weber S, Van den Haute C, Waldenmaier A, Görner K, et al. Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6. EMBO J. 2010;29:209-21 pubmed 出版商
  • 免疫组化; 人类
Kovacs G, Majtenyi K, Spina S, Murrell J, Gelpi E, Hoftberger R, et al. White matter tauopathy with globular glial inclusions: a distinct sporadic frontotemporal lobar degeneration. J Neuropathol Exp Neurol. 2008;67:963-75 pubmed 出版商
  • 免疫组化; 人类
Lin W, Dickson D. Ultrastructural localization of TDP-43 in filamentous neuronal inclusions in various neurodegenerative diseases. Acta Neuropathol. 2008;116:205-13 pubmed 出版商
  • 免疫组化; 人类
Igaz L, Kwong L, Xu Y, Truax A, Uryu K, Neumann M, et al. Enrichment of C-terminal fragments in TAR DNA-binding protein-43 cytoplasmic inclusions in brain but not in spinal cord of frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Am J Pathol. 2008;173:182-94 pubmed 出版商
  • 免疫印迹; 人类
Foulds P, McAuley E, Gibbons L, Davidson Y, Pickering Brown S, Neary D, et al. TDP-43 protein in plasma may index TDP-43 brain pathology in Alzheimer's disease and frontotemporal lobar degeneration. Acta Neuropathol. 2008;116:141-6 pubmed 出版商
Yagensky O, Kohansal Nodehi M, Gunaseelan S, Rabe T, Zafar S, Zerr I, et al. Increased expression of heme-binding protein 1 early in Alzheimer's disease is linked to neurotoxicity. elife. 2019;8: pubmed 出版商
Fang M, Markmiller S, Vu A, Javaherian A, Dowdle W, Jolivet P, et al. Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD. Neuron. 2019;: pubmed 出版商
Yin P, Guo X, Yang W, Yan S, Yang S, Zhao T, et al. Caspase-4 mediates cytoplasmic accumulation of TDP-43 in the primate brains. Acta Neuropathol. 2019;137:919-937 pubmed 出版商
Solomon D, Stepto A, Au W, Adachi Y, Diaper D, Hall R, et al. A feedback loop between dipeptide-repeat protein, TDP-43 and karyopherin-α mediates C9orf72-related neurodegeneration. Brain. 2018;141:2908-2924 pubmed 出版商
Archbold H, Jackson K, Arora A, Weskamp K, Tank E, Li X, et al. TDP43 nuclear export and neurodegeneration in models of amyotrophic lateral sclerosis and frontotemporal dementia. Sci Rep. 2018;8:4606 pubmed 出版商
Feneberg E, Gray E, Ansorge O, Talbot K, Turner M. Towards a TDP-43-Based Biomarker for ALS and FTLD. Mol Neurobiol. 2018;55:7789-7801 pubmed 出版商
Gregory J, Whiten D, Brown R, Barros T, Kumita J, Yerbury J, et al. Clusterin protects neurons against intracellular proteotoxicity. Acta Neuropathol Commun. 2017;5:81 pubmed 出版商
Koyama A, Sugai A, Kato T, Ishihara T, Shiga A, Toyoshima Y, et al. Increased cytoplasmic TARDBP mRNA in affected spinal motor neurons in ALS caused by abnormal autoregulation of TDP-43. Nucleic Acids Res. 2016;44:5820-36 pubmed 出版商
Walker A, Soo K, Sundaramoorthy V, Parakh S, Ma Y, Farg M, et al. ALS-associated TDP-43 induces endoplasmic reticulum stress, which drives cytoplasmic TDP-43 accumulation and stress granule formation. PLoS ONE. 2013;8:e81170 pubmed 出版商
Nishimoto Y, Nakagawa S, Hirose T, Okano H, Takao M, Shibata S, et al. The long non-coding RNA nuclear-enriched abundant transcript 1_2 induces paraspeckle formation in the motor neuron during the early phase of amyotrophic lateral sclerosis. Mol Brain. 2013;6:31 pubmed 出版商
Bosque P, Boyer P, Mishra P. A 43-kDa TDP-43 species is present in aggregates associated with frontotemporal lobar degeneration. PLoS ONE. 2013;8:e62301 pubmed 出版商
Tong J, Huang C, Bi F, Wu Q, Huang B, Zhou H. XBP1 depletion precedes ubiquitin aggregation and Golgi fragmentation in TDP-43 transgenic rats. J Neurochem. 2012;123:406-16 pubmed 出版商
Lopez Gonzalez I, Carmona M, Blanco R, Luna Munoz J, Martínez Mandonado A, Mena R, et al. Characterization of thorn-shaped astrocytes in white matter of temporal lobe in Alzheimer's disease brains. Brain Pathol. 2013;23:144-53 pubmed 出版商
Verstraete E, Kuiperij H, van Blitterswijk M, Veldink J, Schelhaas H, van den Berg L, et al. TDP-43 plasma levels are higher in amyotrophic lateral sclerosis. Amyotroph Lateral Scler. 2012;13:446-51 pubmed 出版商
Gelpi E, Soler Insa J, Parchi P, Saverioni D, Yague J, Nos C, et al. Atypical neuropathological sCJD-MM phenotype with abundant white matter Kuru-type plaques sparing the cerebellar cortex. Neuropathology. 2013;33:204-8 pubmed 出版商
Colom Cadena M, Gelpi E, Marti M, Charif S, Dols Icardo O, Blesa R, et al. MAPT H1 haplotype is associated with enhanced ?-synuclein deposition in dementia with Lewy bodies. Neurobiol Aging. 2013;34:936-42 pubmed 出版商
Vilas D, Marti M, Botta Orfila T, Colom Cadena M, Gelpi E. Pick's pathology in Parkinson's disease with dementia. Neuropathol Appl Neurobiol. 2012;38:737-43 pubmed 出版商
Echávarri C, Burgmans S, Caballero M, Garcia Bragado F, Verhey F, Uylings H. Co-occurrence of different pathologies in dementia: implications for dementia diagnosis. J Alzheimers Dis. 2012;30:909-17 pubmed 出版商
Herman A, Khandelwal P, Rebeck G, Moussa C. Wild type TDP-43 induces neuro-inflammation and alters APP metabolism in lentiviral gene transfer models. Exp Neurol. 2012;235:297-305 pubmed 出版商
Troakes C, Maekawa S, Wijesekera L, Rogelj B, Siklós L, Bell C, et al. An MND/ALS phenotype associated with C9orf72 repeat expansion: abundant p62-positive, TDP-43-negative inclusions in cerebral cortex, hippocampus and cerebellum but without associated cognitive decline. Neuropathology. 2012;32:505-14 pubmed 出版商
Dayton R, Wang D, Cain C, Schrott L, Ramirez J, King M, et al. Frontotemporal lobar degeneration-related proteins induce only subtle memory-related deficits when bilaterally overexpressed in the dorsal hippocampus. Exp Neurol. 2012;233:807-14 pubmed 出版商
Huang C, Tong J, Bi F, Zhou H, Xia X. Mutant TDP-43 in motor neurons promotes the onset and progression of ALS in rats. J Clin Invest. 2012;122:107-18 pubmed 出版商
Tsuji H, Nonaka T, Yamashita M, Masuda Suzukake M, Kametani F, Akiyama H, et al. Epitope mapping of antibodies against TDP-43 and detection of protease-resistant fragments of pathological TDP-43 in amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Biochem Biophys Res Commun. 2012;417:116-21 pubmed 出版商
Fiesel F, Weber S, Supper J, Zell A, Kahle P. TDP-43 regulates global translational yield by splicing of exon junction complex component SKAR. Nucleic Acids Res. 2012;40:2668-82 pubmed 出版商
Antonell A, Gelpi E, Sanchez Valle R, Martinez R, Molinuevo J, Lladó A. Breakpoint sequence analysis of an A?PP locus duplication associated with autosomal dominant Alzheimer's disease and severe cerebral amyloid angiopathy. J Alzheimers Dis. 2012;28:303-8 pubmed 出版商
Thom M, Liu J, Thompson P, Phadke R, Narkiewicz M, Martinian L, et al. Neurofibrillary tangle pathology and Braak staging in chronic epilepsy in relation to traumatic brain injury and hippocampal sclerosis: a post-mortem study. Brain. 2011;134:2969-81 pubmed 出版商
Wang J, Brent J, Tomlinson A, Shneider N, McCabe B. The ALS-associated proteins FUS and TDP-43 function together to affect Drosophila locomotion and life span. J Clin Invest. 2011;121:4118-26 pubmed 出版商
Swarup V, Phaneuf D, Bareil C, Robertson J, Rouleau G, Kriz J, et al. Pathological hallmarks of amyotrophic lateral sclerosis/frontotemporal lobar degeneration in transgenic mice produced with TDP-43 genomic fragments. Brain. 2011;134:2610-26 pubmed 出版商
Martínez Sáez E, Gelpi E, Rey M, Ferrer I, Ribalta T, Botta Orfila T, et al. Hirano body-rich subtypes of Creutzfeldt-Jakob disease. Neuropathol Appl Neurobiol. 2012;38:153-61 pubmed 出版商
Azizi A, Li L, Strobel T, Chen W, Slavc I, Lubec G. Identification of c-myc-dependent proteins in the medulloblastoma cell line D425Med. Amino Acids. 2012;42:2149-63 pubmed 出版商
López Hernández T, Sirisi S, Capdevila Nortes X, Montolio M, Fernández Dueñas V, Scheper G, et al. Molecular mechanisms of MLC1 and GLIALCAM mutations in megalencephalic leukoencephalopathy with subcortical cysts. Hum Mol Genet. 2011;20:3266-77 pubmed 出版商
Rusina R, Kovacs G, Fiala J, Hort J, Ridzon P, Holmerová I, et al. FTLD-TDP with motor neuron disease, visuospatial impairment and a progressive supranuclear palsy-like syndrome: broadening the clinical phenotype of TDP-43 proteinopathies. A report of three cases. BMC Neurol. 2011;11:50 pubmed 出版商
Mundiñano I, Caballero M, Ordóñez C, Hernandez M, Dicaudo C, Marcilla I, et al. Increased dopaminergic cells and protein aggregates in the olfactory bulb of patients with neurodegenerative disorders. Acta Neuropathol. 2011;122:61-74 pubmed 出版商
Pikkarainen M, Hartikainen P, Soininen H, Alafuzoff I. Distribution and pattern of pathology in subjects with familial or sporadic late-onset cerebellar ataxia as assessed by p62/sequestosome immunohistochemistry. Cerebellum. 2011;10:720-31 pubmed 出版商
Hartikainen P, Pikkarainen M, Hanninen T, Soininen H, Alafuzoff I. Unusual clinical presentation and neuropathology in two subjects with fused-in sarcoma (FUS) positive inclusions. Neuropathology. 2012;32:60-8 pubmed 出版商
Che M, Jiang Y, Xie Y, Jiang L, Hu H. Aggregation of the 35-kDa fragment of TDP-43 causes formation of cytoplasmic inclusions and alteration of RNA processing. FASEB J. 2011;25:2344-53 pubmed 出版商
Tian T, Huang C, Tong J, Yang M, Zhou H, Xia X. TDP-43 potentiates alpha-synuclein toxicity to dopaminergic neurons in transgenic mice. Int J Biol Sci. 2011;7:234-43 pubmed
Herman A, Khandelwal P, Stanczyk B, Rebeck G, Moussa C. ?-amyloid triggers ALS-associated TDP-43 pathology in AD models. Brain Res. 2011;1386:191-9 pubmed 出版商
Lashley T, Holton J, Revesz T. TDP-43 pathology may occur in the BRI2 gene-related dementias. Acta Neuropathol. 2011;121:559-60 pubmed 出版商
Rauramaa T, Pikkarainen M, Englund E, Ince P, Jellinger K, Paetau A, et al. TAR-DNA binding protein-43 and alterations in the hippocampus. J Neural Transm (Vienna). 2011;118:683-9 pubmed 出版商
Noto Y, Shibuya K, Sato Y, Kanai K, Misawa S, Sawai S, et al. Elevated CSF TDP-43 levels in amyotrophic lateral sclerosis: specificity, sensitivity, and a possible prognostic value. Amyotroph Lateral Scler. 2011;12:140-3 pubmed 出版商
De Marco G, Lupino E, Calvo A, Moglia C, Buccinnà B, Grifoni S, et al. Cytoplasmic accumulation of TDP-43 in circulating lymphomonocytes of ALS patients with and without TARDBP mutations. Acta Neuropathol. 2011;121:611-22 pubmed 出版商
Higashi S, Tsuchiya Y, Araki T, Wada K, Kabuta T. TDP-43 physically interacts with amyotrophic lateral sclerosis-linked mutant CuZn superoxide dismutase. Neurochem Int. 2010;57:906-13 pubmed 出版商
Wang D, Dayton R, Henning P, Cain C, Zhao L, Schrott L, et al. Expansive gene transfer in the rat CNS rapidly produces amyotrophic lateral sclerosis relevant sequelae when TDP-43 is overexpressed. Mol Ther. 2010;18:2064-74 pubmed 出版商
Hoftberger R, Fink S, Aboul Enein F, Botond G, Olah J, Berki T, et al. Tubulin polymerization promoting protein (TPPP/p25) as a marker for oligodendroglial changes in multiple sclerosis. Glia. 2010;58:1847-57 pubmed 出版商
Xu Y, Gendron T, Zhang Y, Lin W, D Alton S, Sheng H, et al. Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor deficits, and early mortality in transgenic mice. J Neurosci. 2010;30:10851-9 pubmed 出版商
Ling S, Albuquerque C, Han J, Lagier Tourenne C, Tokunaga S, Zhou H, et al. ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS. Proc Natl Acad Sci U S A. 2010;107:13318-23 pubmed 出版商
Jansen C, Head M, van Gool W, Baas F, Yull H, Ironside J, et al. The first case of protease-sensitive prionopathy (PSPr) in The Netherlands: a patient with an unusual GSS-like clinical phenotype. J Neurol Neurosurg Psychiatry. 2010;81:1052-5 pubmed 出版商
Ash P, Zhang Y, Roberts C, Saldi T, Hutter H, Buratti E, et al. Neurotoxic effects of TDP-43 overexpression in C. elegans. Hum Mol Genet. 2010;19:3206-18 pubmed 出版商
Maruyama H, Morino H, Ito H, Izumi Y, Kato H, Watanabe Y, et al. Mutations of optineurin in amyotrophic lateral sclerosis. Nature. 2010;465:223-6 pubmed 出版商
Braak H, Ludolph A, Thal D, Del Tredici K. Amyotrophic lateral sclerosis: dash-like accumulation of phosphorylated TDP-43 in somatodendritic and axonal compartments of somatomotor neurons of the lower brainstem and spinal cord. Acta Neuropathol. 2010;120:67-74 pubmed 出版商
Ilieva E, Naudi A, Kichev A, Ferrer I, Pamplona R, Portero Otin M. Depletion of oxidative and endoplasmic reticulum stress regulators in Pick disease. Free Radic Biol Med. 2010;48:1302-10 pubmed 出版商
Wils H, Kleinberger G, Janssens J, Pereson S, Joris G, Cuijt I, et al. TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration. Proc Natl Acad Sci U S A. 2010;107:3858-63 pubmed 出版商
Zhang H, Tanji K, Yoshida H, Hayakari M, Shibata T, Mori F, et al. Alteration of biochemical and pathological properties of TDP-43 protein by a lipid mediator, 15-deoxy-Delta(12,14)-prostaglandin J(2). Exp Neurol. 2010;222:296-303 pubmed 出版商
Nishimoto Y, Ito D, Yagi T, Nihei Y, Tsunoda Y, Suzuki N. Characterization of alternative isoforms and inclusion body of the TAR DNA-binding protein-43. J Biol Chem. 2010;285:608-19 pubmed 出版商
Foulds P, Davidson Y, Mishra M, Hobson D, Humphreys K, Taylor M, et al. Plasma phosphorylated-TDP-43 protein levels correlate with brain pathology in frontotemporal lobar degeneration. Acta Neuropathol. 2009;118:647-58 pubmed 出版商
Velakoulis D, Walterfang M, Mocellin R, Pantelis C, Dean B, McLean C. Abnormal hippocampal distribution of TDP-43 in patients with-late onset psychosis. Aust N Z J Psychiatry. 2009;43:739-45 pubmed 出版商
Moisse K, Mepham J, Volkening K, Welch I, Hill T, Strong M. Cytosolic TDP-43 expression following axotomy is associated with caspase 3 activation in NFL-/- mice: support for a role for TDP-43 in the physiological response to neuronal injury. Brain Res. 2009;1296:176-86 pubmed 出版商
Velakoulis D, Walterfang M, Mocellin R, Pantelis C, McLean C. Frontotemporal dementia presenting as schizophrenia-like psychosis in young people: clinicopathological series and review of cases. Br J Psychiatry. 2009;194:298-305 pubmed 出版商
Humayun S, Gohar M, Volkening K, Moisse K, Leystra Lantz C, Mepham J, et al. The complement factor C5a receptor is upregulated in NFL-/- mouse motor neurons. J Neuroimmunol. 2009;210:52-62 pubmed 出版商
Gitcho M, Strider J, Carter D, Taylor Reinwald L, Forman M, Goate A, et al. VCP mutations causing frontotemporal lobar degeneration disrupt localization of TDP-43 and induce cell death. J Biol Chem. 2009;284:12384-98 pubmed 出版商
Olive M, Janué A, Moreno D, Gamez J, Torrejón Escribano B, Ferrer I. TAR DNA-Binding protein 43 accumulation in protein aggregate myopathies. J Neuropathol Exp Neurol. 2009;68:262-73 pubmed 出版商
Rollinson S, Rizzu P, Sikkink S, Baker M, Halliwell N, Snowden J, et al. Ubiquitin associated protein 1 is a risk factor for frontotemporal lobar degeneration. Neurobiol Aging. 2009;30:656-65 pubmed 出版商
Igaz L, Kwong L, Chen Plotkin A, Winton M, Unger T, Xu Y, et al. Expression of TDP-43 C-terminal Fragments in Vitro Recapitulates Pathological Features of TDP-43 Proteinopathies. J Biol Chem. 2009;284:8516-24 pubmed 出版商
Clarimon J, Molina Porcel L, Gomez Isla T, Blesa R, Guardia Laguarta C, Gonzalez Neira A, et al. Early-onset familial lewy body dementia with extensive tauopathy: a clinical, genetic, and neuropathological study. J Neuropathol Exp Neurol. 2009;68:73-82 pubmed 出版商
Moisse K, Volkening K, Leystra Lantz C, Welch I, Hill T, Strong M. Divergent patterns of cytosolic TDP-43 and neuronal progranulin expression following axotomy: implications for TDP-43 in the physiological response to neuronal injury. Brain Res. 2009;1249:202-11 pubmed 出版商
Schwab C, Arai T, Hasegawa M, Yu S, McGeer P. Colocalization of transactivation-responsive DNA-binding protein 43 and huntingtin in inclusions of Huntington disease. J Neuropathol Exp Neurol. 2008;67:1159-65 pubmed 出版商
Steinacker P, Hendrich C, Sperfeld A, Jesse S, von Arnim C, Lehnert S, et al. TDP-43 in cerebrospinal fluid of patients with frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Arch Neurol. 2008;65:1481-7 pubmed 出版商
Seppänen A, Pikkarainen M, Hartikainen P, Hofmann S, Majamaa K, Alafuzoff I. Expression of collagen XVII and ubiquitin-binding protein p62 in motor neuron disease. Brain Res. 2009;1247:171-7 pubmed 出版商
Kasai T, Tokuda T, Ishigami N, Sasayama H, Foulds P, Mitchell D, et al. Increased TDP-43 protein in cerebrospinal fluid of patients with amyotrophic lateral sclerosis. Acta Neuropathol. 2009;117:55-62 pubmed 出版商
Nishihira Y, Tan C, Hoshi Y, Iwanaga K, Yamada M, Kawachi I, et al. Sporadic amyotrophic lateral sclerosis of long duration is associated with relatively mild TDP-43 pathology. Acta Neuropathol. 2009;117:45-53 pubmed 出版商
Skoglund L, Brundin R, Olofsson T, Kalimo H, Ingvast S, Blom E, et al. Frontotemporal dementia in a large Swedish family is caused by a progranulin null mutation. Neurogenetics. 2009;10:27-34 pubmed 出版商
Miklossy J, Steele J, Yu S, McCall S, Sandberg G, McGeer E, et al. Enduring involvement of tau, beta-amyloid, alpha-synuclein, ubiquitin and TDP-43 pathology in the amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam (ALS/PDC). Acta Neuropathol. 2008;116:625-37 pubmed 出版商
Weihl C, Temiz P, Miller S, Watts G, Smith C, Forman M, et al. TDP-43 accumulation in inclusion body myopathy muscle suggests a common pathogenic mechanism with frontotemporal dementia. J Neurol Neurosurg Psychiatry. 2008;79:1186-9 pubmed 出版商
Mori F, Tanji K, Zhang H, Nishihira Y, Tan C, Takahashi H, et al. Maturation process of TDP-43-positive neuronal cytoplasmic inclusions in amyotrophic lateral sclerosis with and without dementia. Acta Neuropathol. 2008;116:193-203 pubmed 出版商
Sleegers K, Kumar Singh S, Cruts M, Van Broeckhoven C. Molecular pathogenesis of frontotemporal lobar degeneration: basic science seminar in neurology. Arch Neurol. 2008;65:700-4 pubmed 出版商
Johnson B, McCaffery J, Lindquist S, Gitler A. A yeast TDP-43 proteinopathy model: Exploring the molecular determinants of TDP-43 aggregation and cellular toxicity. Proc Natl Acad Sci U S A. 2008;105:6439-44 pubmed 出版商
Winton M, Igaz L, Wong M, Kwong L, Trojanowski J, Lee V. Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formation. J Biol Chem. 2008;283:13302-9 pubmed 出版商
Zhang H, Tanji K, Mori F, Wakabayashi K. Epitope mapping of 2E2-D3, a monoclonal antibody directed against human TDP-43. Neurosci Lett. 2008;434:170-4 pubmed 出版商
Beck J, Rohrer J, Campbell T, Isaacs A, Morrison K, Goodall E, et al. A distinct clinical, neuropsychological and radiological phenotype is associated with progranulin gene mutations in a large UK series. Brain. 2008;131:706-20 pubmed 出版商
Sanelli T, Xiao S, Horne P, Bilbao J, Zinman L, Robertson J. Evidence that TDP-43 is not the major ubiquitinated target within the pathological inclusions of amyotrophic lateral sclerosis. J Neuropathol Exp Neurol. 2007;66:1147-53 pubmed
Kovacs G, Pittman A, Revesz T, Luk C, Lees A, Kiss E, et al. MAPT S305I mutation: implications for argyrophilic grain disease. Acta Neuropathol. 2008;116:103-18 pubmed
Shankaran S, Capell A, Hruscha A, Fellerer K, Neumann M, Schmid B, et al. Missense mutations in the progranulin gene linked to frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions reduce progranulin production and secretion. J Biol Chem. 2008;283:1744-53 pubmed
Zhang H, Tan C, Mori F, Tanji K, Kakita A, Takahashi H, et al. TDP-43-immunoreactive neuronal and glial inclusions in the neostriatum in amyotrophic lateral sclerosis with and without dementia. Acta Neuropathol. 2008;115:115-22 pubmed
Amador Ortiz C, Lin W, Ahmed Z, Personett D, Davies P, Duara R, et al. TDP-43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease. Ann Neurol. 2007;61:435-45 pubmed
Mackenzie I, Bigio E, Ince P, Geser F, Neumann M, Cairns N, et al. Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations. Ann Neurol. 2007;61:427-34 pubmed
Hasegawa M, Arai T, Akiyama H, Nonaka T, Mori H, Hashimoto T, et al. TDP-43 is deposited in the Guam parkinsonism-dementia complex brains. Brain. 2007;130:1386-94 pubmed
Neumann M, Kwong L, Truax A, Vanmassenhove B, Kretzschmar H, Van Deerlin V, et al. TDP-43-positive white matter pathology in frontotemporal lobar degeneration with ubiquitin-positive inclusions. J Neuropathol Exp Neurol. 2007;66:177-83 pubmed
Tan C, Eguchi H, Tagawa A, Onodera O, Iwasaki T, Tsujino A, et al. TDP-43 immunoreactivity in neuronal inclusions in familial amyotrophic lateral sclerosis with or without SOD1 gene mutation. Acta Neuropathol. 2007;113:535-42 pubmed
Neumann M, Mackenzie I, Cairns N, Boyer P, Markesbery W, Smith C, et al. TDP-43 in the ubiquitin pathology of frontotemporal dementia with VCP gene mutations. J Neuropathol Exp Neurol. 2007;66:152-7 pubmed
Arai T, Hasegawa M, Akiyama H, Ikeda K, Nonaka T, Mori H, et al. TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Biochem Biophys Res Commun. 2006;351:602-11 pubmed
产品信息
目录号码 :
H00023435-M01
产品名称 :
TARDBP单克隆抗体(M01), 克隆2E2-D3
产品描述 :
Mouse monoclonal antibody raised against a partial recombinant TARDBP.
克隆名称 :
2E2-D3
抗体亚型 :
IgG1 Kappa
基因名称 :
TARDBP
基因别名 :
ALS10 TDP-43
基因描述 :
焦油DNA结合蛋白
GenBank登录号 :
NM_007375.3
免疫原 :
TARDBP (NP_031401.1, 1 a.a. ~ 260 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
免疫原序列蛋白序列 :
MSEYIRVTEDENDEPIEIPSEDDGTVLLSTVTAQFPGAC
GLRYRNPVSQCMRGVRLVEGILHAPDAGWGNLVYVVNYP
KDNKRKMDETDASSAVKVKRAVQKTSDLIVLGLPWKTTE
QDLKEYFSTFGEVLMVQVKKDLKTGHSKGFGFVRFTEYE
TQVKVMSQRHMIDGRWCDCKLPNSKQSQDEPLRSRKVFV
GRCTEDMTEDELREFFSQYGDVMDVFIPKPFRAFAFVTF
ADDQIAQSLCGEDLIIKGISVHISNA
蛋白登录号 :
NP_031401.1
储存缓冲液 :
在1x PBS, pH值7.4
储存说明 :
储存在-20℃或更低。分装以避免反复冻融
质量控制试验 :
抗体能识别重组蛋白
类型克隆性 :
抗体
宿主物种 :
小鼠
抗原物种靶物种 :
人类
物种活性交叉活性 :
人类
应用 :
S-ELISA,IP,WB-Tr,RNAi-Ab,ELISA,WB-Re,WB-Ce,IF,IHC-P
规格 :
100微克
开始日期 :
4/18/08
更新日期 :
2/25/16 14:12
公司信息
亚诺法生技股份有限公司
台湾台北市內湖區洲子街108號9樓
sales@abnova.com
https://www.abnova.com
886-2-87511888