NFM-NM-:B p50 is a member of the NFM-NM-:B family of transcription factors that are involved in processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. The Rel family includes c-Rel, RelA (NFM-NM-:B p65, NFM-NM-:B3) and RelB (I-Rel). Rel proteins form dimers with the NFM-NM-:B p50 (proteolytically processed from p105/NFM-NM-:B1) and p52 (proteolytically processed from p100/NFM-NM-:B2) members of the NFM-NM-:B family. The NFM-NM-:B p65/p50 heterodimer is the most abundant form of NFM-NM-:B.NFM-NM-:B signaling is negatively regulated by the sequestration of the NFM-NM-:B complex in the cytoplasm by its association with the IM-NM-:B family of inhibitory proteins. The IM-NM-:B Kinase (IKK) complex is the key enzyme involved in the activation and translocation of NFM-NM-:B. The IKK complex is composed of two catalytic subunits (IKKM-NM-1 and IKKM-NM-2) and a regulatory subunit (IKKM-NM-3). Upon its activation, the IKK complex phosphorylates IM-NM-:B proteins (IM-NM-:BM-NM-1, IM-NM-:BM-NM-1 phospho Ser32, 36), which marks them for ubiquitination and degradation. This enables the NFM-NM-:B complex to translocate to the nucleus where it regulates transcription by binding to DNA.
This NFkB p50 antibody was raised against a synthetic peptide corresponding to amino acid residues 363-376 of human NFM-NM-:B p50.
Antibodies in solution can be stored at -80M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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