产品简要
公司名称 :
Active Motif
其他品牌 :
Geneka Biotechnology
产品类型 :
抗体
产品名称 :
组蛋白H3K4me3抗体(多克隆抗体)
目录 :
39159
规格 :
200微升
价格 :
350美元
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
Austrofundulus limnaeus, 人类, 小鼠, 斑马鱼, S. cerevisiae, 非洲爪蛙
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫细胞化学, 免疫沉淀, 染色质免疫沉淀 , ChIP-Seq
更多信息或购买 :
文章摘录数: 42
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠; 1:1000; 图 5a
Chen X, Zhi X, Wang J, Su J. RANKL signaling in bone marrow mesenchymal stem cells negatively regulates osteoblastic bone formation. Bone Res. 2018;6:34 pubmed 出版商
  • ChIP-Seq; 人类; 图 5b
Stewart E, McEvoy J, Wang H, Chen X, Honnell V, Ocarz M, et al. Identification of Therapeutic Targets in Rhabdomyosarcoma through Integrated Genomic, Epigenomic, and Proteomic Analyses. Cancer Cell. 2018;34:411-426.e19 pubmed 出版商
  • ChIP-Seq; 斑马鱼; 图 s1a
Murphy P, Wu S, James C, Wike C, Cairns B. Placeholder Nucleosomes Underlie Germline-to-Embryo DNA Methylation Reprogramming. Cell. 2018;172:993-1006.e13 pubmed 出版商
  • ChIP-Seq; 小鼠; 图 4a
Fujita J, Freire P, Coarfa C, Benham A, Gunaratne P, Schneider M, et al. Ronin Governs Early Heart Development by Controlling Core Gene Expression Programs. Cell Rep. 2017;21:1562-1573 pubmed 出版商
  • ChIP-Seq; 小鼠; 图 1b
Cruz Molina S, Respuela P, Tebartz C, Kolovos P, Nikolic M, Fueyo R, et al. PRC2 Facilitates the Regulatory Topology Required for Poised Enhancer Function during Pluripotent Stem Cell Differentiation. Cell Stem Cell. 2017;20:689-705.e9 pubmed 出版商
  • 染色质免疫沉淀 ; S. cerevisiae; 图 s2a
  • 免疫印迹; S. cerevisiae; 1:3000-1:5000; 图 1a
Young C, Hillyer C, Hokamp K, Fitzpatrick D, Konstantinov N, Welty J, et al. Distinct histone methylation and transcription profiles are established during the development of cellular quiescence in yeast. BMC Genomics. 2017;18:107 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 图 s2
Ho T, Huang J, Zhou N, Zhang Z, Koirala P, Zhou X, et al. Regulation of PCGEM1 by p54/nrb in prostate cancer. Sci Rep. 2016;6:34529 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 图 5
Amabile A, Migliara A, Capasso P, Biffi M, Cittaro D, Naldini L, et al. Inheritable Silencing of Endogenous Genes by Hit-and-Run Targeted Epigenetic Editing. Cell. 2016;167:219-232.e14 pubmed 出版商
  • ChIP-Seq; 非洲爪蛙; 图 6b
Walentek P, Quigley I, Sun D, Sajjan U, Kintner C, Harland R. Ciliary transcription factors and miRNAs precisely regulate Cp110 levels required for ciliary adhesions and ciliogenesis. elife. 2016;5: pubmed 出版商
  • ChIP-Seq; 小鼠; 图 4
Omata Y, Nakamura S, Koyama T, Yasui T, Hirose J, Izawa N, et al. Identification of Nedd9 as a TGF-?-Smad2/3 Target Gene Involved in RANKL-Induced Osteoclastogenesis by Comprehensive Analysis. PLoS ONE. 2016;11:e0157992 pubmed 出版商
  • 免疫印迹; 小鼠; 图 s6d
Lu C, Jain S, Hoelper D, Bechet D, Molden R, Ran L, et al. Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape. Science. 2016;352:844-9 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 图 6
Kushwaha R, Jagadish N, Kustagi M, Mendiratta G, Seandel M, Soni R, et al. Mechanism and Role of SOX2 Repression in Seminoma: Relevance to Human Germline Specification. Stem Cell Reports. 2016;6:772-783 pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠; 图 4b
Garcia Cuellar M, Büttner C, Bartenhagen C, Dugas M, Slany R. Leukemogenic MLL-ENL Fusions Induce Alternative Chromatin States to Drive a Functionally Dichotomous Group of Target Genes. Cell Rep. 2016;15:310-22 pubmed 出版商
  • 免疫印迹; 人类; 图 s3s
Taniue K, Kurimoto A, Sugimasa H, Nasu E, Takeda Y, Iwasaki K, et al. Long noncoding RNA UPAT promotes colon tumorigenesis by inhibiting degradation of UHRF1. Proc Natl Acad Sci U S A. 2016;113:1273-8 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 5
Pan H, Guan D, Liu X, Li J, Wang L, Wu J, et al. SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2. Cell Res. 2016;26:190-205 pubmed 出版商
  • ChIP-Seq; 小鼠; 图 2b
  • 免疫印迹; 小鼠; 图 1c
Yang Y, Li W, Hoque M, Hou L, Shen S, Tian B, et al. PAF Complex Plays Novel Subunit-Specific Roles in Alternative Cleavage and Polyadenylation. PLoS Genet. 2016;12:e1005794 pubmed 出版商
  • 酶联免疫吸附测定; Austrofundulus limnaeus; 1:1000; 图 5f
Toni L, Padilla P. Developmentally arrested Austrofundulus limnaeus embryos have changes in post-translational modifications of histone H3. J Exp Biol. 2016;219:544-52 pubmed 出版商
Roy A, Ghosh A, Kumar B, Chandran B. IFI16, a nuclear innate immune DNA sensor, mediates epigenetic silencing of herpesvirus genomes by its association with H3K9 methyltransferases SUV39H1 and GLP. elife. 2019;8: pubmed 出版商
Mahmoudi S, Mancini E, Xu L, Moore A, Jahanbani F, Hebestreit K, et al. Heterogeneity in old fibroblasts is linked to variability in reprogramming and wound healing. Nature. 2019;574:553-558 pubmed 出版商
Kaya Okur H, Wu S, Codomo C, Pledger E, Bryson T, Henikoff J, et al. CUT&Tag for efficient epigenomic profiling of small samples and single cells. Nat Commun. 2019;10:1930 pubmed 出版商
Kalkan T, Bornelöv S, Mulas C, Diamanti E, Lohoff T, Ralser M, et al. Complementary Activity of ETV5, RBPJ, and TCF3 Drives Formative Transition from Naive Pluripotency. Cell Stem Cell. 2019;24:785-801.e7 pubmed 出版商
Scelfo A, Fernandez Perez D, Tamburri S, Zanotti M, Lavarone E, Soldi M, et al. Functional Landscape of PCGF Proteins Reveals Both RING1A/B-Dependent-and RING1A/B-Independent-Specific Activities. Mol Cell. 2019;74:1037-1052.e7 pubmed 出版商
Arya R, Gyonjyan S, Harding K, Sarkissian T, Li Y, Zhou L, et al. A Cut/cohesin axis alters the chromatin landscape to facilitate neuroblast death. Development. 2019;146: pubmed 出版商
Watanabe S, Shimada S, Akiyama Y, Ishikawa Y, Ogura T, Ogawa K, et al. Loss of KDM6A characterizes a poor prognostic subtype of human pancreatic cancer and potentiates HDAC inhibitor lethality. Int J Cancer. 2019;145:192-205 pubmed 出版商
Erkek S, Johann P, Finetti M, Drosos Y, Chou H, Zapatka M, et al. Comprehensive Analysis of Chromatin States in Atypical Teratoid/Rhabdoid Tumor Identifies Diverging Roles for SWI/SNF and Polycomb in Gene Regulation. Cancer Cell. 2018;: pubmed 出版商
Selimoglu Buet D, Rivière J, Ghamlouch H, Bencheikh L, Lacout C, Morabito M, et al. A miR-150/TET3 pathway regulates the generation of mouse and human non-classical monocyte subset. Nat Commun. 2018;9:5455 pubmed 出版商
Koohy H, Bolland D, Matheson L, Schoenfelder S, Stellato C, Dimond A, et al. Genome organization and chromatin analysis identify transcriptional downregulation of insulin-like growth factor signaling as a hallmark of aging in developing B cells. Genome Biol. 2018;19:126 pubmed 出版商
Kong X, Martinez Barricarte R, Kennedy J, Mele F, Lazarov T, Deenick E, et al. Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiency. Nat Immunol. 2018;19:973-985 pubmed 出版商
Fuentes D, Swigut T, Wysocka J. Systematic perturbation of retroviral LTRs reveals widespread long-range effects on human gene regulation. elife. 2018;7: pubmed 出版商
Janevska S, Guldener U, Sulyok M, Tudzynski B, Studt L. Set1 and Kdm5 are antagonists for H3K4 methylation and regulators of the major conidiation-specific transcription factor gene ABA1 in Fusarium fujikuroi. Environ Microbiol. 2018;20:3343-3362 pubmed 出版商
Cho S, Xu J, Sun R, Mumbach M, Carter A, Chen Y, et al. Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element. Cell. 2018;173:1398-1412.e22 pubmed 出版商
Numata A, Kwok H, Kawasaki A, Li J, Zhou Q, Kerry J, et al. The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia. Nat Commun. 2018;9:1622 pubmed 出版商
Ran L, Chen Y, Sher J, Wong E, Murphy D, Zhang J, et al. FOXF1 Defines the Core-Regulatory Circuitry in Gastrointestinal Stromal Tumor. Cancer Discov. 2018;8:234-251 pubmed 出版商
Li P, Wang L, Bennett B, Wang J, Li J, Qin Y, et al. Rif1 promotes a repressive chromatin state to safeguard against endogenous retrovirus activation. Nucleic Acids Res. 2017;45:12723-12738 pubmed 出版商
Soldi M, Mari T, Nicosia L, Musiani D, Sigismondo G, Cuomo A, et al. Chromatin proteomics reveals novel combinatorial histone modification signatures that mark distinct subpopulations of macrophage enhancers. Nucleic Acids Res. 2017;: pubmed 出版商
Korb E, Herre M, Zucker Scharff I, Gresack J, Allis C, Darnell R. Excess Translation of Epigenetic Regulators Contributes to Fragile X Syndrome and Is Alleviated by Brd4 Inhibition. Cell. 2017;170:1209-1223.e20 pubmed 出版商
Dorighi K, Swigut T, Henriques T, Bhanu N, Scruggs B, Nady N, et al. Mll3 and Mll4 Facilitate Enhancer RNA Synthesis and Transcription from Promoters Independently of H3K4 Monomethylation. Mol Cell. 2017;66:568-576.e4 pubmed 出版商
O Hara S, Splinter P, Trussoni C, Pisarello M, Loarca L, Splinter N, et al. ETS Proto-oncogene 1 Transcriptionally Up-regulates the Cholangiocyte Senescence-associated Protein Cyclin-dependent Kinase Inhibitor 2A. J Biol Chem. 2017;292:4833-4846 pubmed 出版商
Das D, Sengupta I, Sarkar N, Pal A, Saha D, Bandopadhyay M, et al. Anti-hepatitis B virus (HBV) response of imiquimod based toll like receptor 7 ligand in hbv-positive human hepatocelluar carcinoma cell line. BMC Infect Dis. 2017;17:76 pubmed 出版商
Wylie A, Jones A, D Brot A, Lu W, Kurtz P, Moran J, et al. p53 genes function to restrain mobile elements. Genes Dev. 2016;30:64-77 pubmed 出版商
Maltby V, Martin B, Brind Amour J, Chruscicki A, McBurney K, Schulze J, et al. Histone H3K4 demethylation is negatively regulated by histone H3 acetylation in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2012;109:18505-10 pubmed 出版商
Schwab K, Smith G, Dressler G. Arrested spermatogenesis and evidence for DNA damage in PTIP mutant testes. Dev Biol. 2013;373:64-71 pubmed 出版商
产品信息
目录代码 :
39159
产品名称 :
组蛋白H3K4me3抗体(多克隆抗体)
宿主物种 :
克隆性 :
多克隆
抗原修饰 :
Methylated
规格 :
200微升
标价 :
350美元
抗体亚型 :
血清
交叉活性 :
Budding Yeast, Human, Other (Wide Range)
背景 :
Histone H3 is one of the core components of the nucleosome. The nucleosome is the smallest subunit of chromatin and consists of 147 base pairs of DNA wrapped around an octamer of core histone proteins (two each of Histone H2A, Histone H2B, Histone H3 and Histone H4). Histone H1 is a linker histone, present at the interface between the nucleosome core and DNA entry/exit points. Histone H1 is responsible for establishing higher-order chromatin structure.Chromatin is subject to a variety of chemical modifications, including post-translational modifications of the histone proteins and the methylation of cytosine residues in the DNA. Reported histone modifications include acetylation, methylation, phosphorylation, ubiquitylation, glycosylation, ADP-ribosylation, carbonylation and SUMOylation; these modifications play a major role in regulating gene expression.The methylation of histones can occur on two different residues: arginine or lysine. Histone methylation can be associated with transcriptional activation or repression, depending on the methylated residue. Lysine 4 of histone H3 can be mono-, di- or trimethylated by different histone methyltransferases (HMTs) such as SET1 or ASH1. Methylation of Lys4 is often associated with transcriptional activation. The demethylase LSD1 is able to demethylate histone H3 Lys4.
免疫原 :
This Histone H3 trimethyl Lys4 antibody was raised against a peptide including trimethyl-lysine 4 of histone H3.
用途 :
ChIP, ChIP-chip, ChIP-Seq, DB, ELISA, IF, IP, WB
储存 :
Antibodies in solution can be stored at -200C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
产品引用 :
References: This antibody has been used as described below:ChIP-Seq: Egelhofer T. et al. (2011) Nature Structural & Molecular Biology 18: 91-93.ChIP: Ieda M. et al. (2010) Cell 142: 375-386; Kolasinska-Zwierz P. et al. (2009) Nat Genet 41:376-381.WB: Baskind H. et al. (2009) Plos One 4:e4750.
更多信息或购买 :
公司信息
Active Motif
787 Kangqiao Road,Building 10, Suite 202,Pudong District,Shanghai, China
techchina@activemotif.com
http://www.activemotif.com
86-21-20926090 400-018-8123
公司总部: 美国