This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
产品简要
公司名称 :
Active Motif
其他品牌 :
Geneka Biotechnology
产品类型 :
抗体
产品名称 :
DNMT1抗体(单克隆抗体)
目录 :
39204
规格 :
100微克
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
60B1220.1

同一抗体克隆可从以下厂商购到:
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫组化, 免疫沉淀, 染色质免疫沉淀
文章摘录数: 9
出版应用/物种/样本/稀释参考文献
  • 染色质免疫沉淀 ; 人类; 图 3
Hervouet E, Claude Taupin A, Gauthier T, Perez V, Fraichard A, Adami P, et al. The autophagy GABARAPL1 gene is epigenetically regulated in breast cancer models. BMC Cancer. 2015;15:729 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1,6,7
  • 免疫印迹; 人类; 图 1,6,7
Liao J, Karnik R, Gu H, Ziller M, Clement K, Tsankov A, et al. Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells. Nat Genet. 2015;47:469-78 pubmed 出版商
  • 免疫印迹; 小鼠
Singh A, Archer T. Analysis of the SWI/SNF chromatin-remodeling complex during early heart development and BAF250a repression cardiac gene transcription during P19 cell differentiation. Nucleic Acids Res. 2014;42:2958-75 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000
Takasugi M, Hayakawa K, Arai D, Shiota K. Age- and sex-dependent DNA hypomethylation controlled by growth hormone in mouse liver. Mech Ageing Dev. 2013;134:331-7 pubmed 出版商
  • 免疫印迹; 小鼠; 1:2000
Wiench M, John S, Baek S, Johnson T, Sung M, Escobar T, et al. DNA methylation status predicts cell type-specific enhancer activity. EMBO J. 2011;30:3028-39 pubmed 出版商
  • 染色质免疫沉淀 ; 人类
  • 免疫印迹; 人类
Karius T, Schnekenburger M, Ghelfi J, Walter J, Dicato M, Diederich M. Reversible epigenetic fingerprint-mediated glutathione-S-transferase P1 gene silencing in human leukemia cell lines. Biochem Pharmacol. 2011;81:1329-42 pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠
Schnekenburger M, Talaska G, Puga A. Chromium cross-links histone deacetylase 1-DNA methyltransferase 1 complexes to chromatin, inhibiting histone-remodeling marks critical for transcriptional activation. Mol Cell Biol. 2007;27:7089-101 pubmed
Zhao X, Hu X. Downregulated long noncoding RNA LINC00313 inhibits the epithelial-mesenchymal transition, invasion, and migration of thyroid cancer cells through inhibiting the methylation of ALX4. J Cell Physiol. 2019;: pubmed 出版商
Galonska C, Charlton J, Mattei A, Donaghey J, Clement K, Gu H, et al. Genome-wide tracking of dCas9-methyltransferase footprints. Nat Commun. 2018;9:597 pubmed 出版商
产品信息
目录代码 :
39204
产品名称 :
DNMT1抗体(单克隆抗体)
宿主物种 :
小鼠
克隆性 :
单克隆
规格 :
100微克
克隆 :
60B1220.1
抗体亚型 :
IgG
交叉活性 :
人类, 小鼠
背景 :
DNMT1 M-bM-^@M-^S DNA methyltransferase 1 (or DNMT 1) proteins are involved in DNA methylation in which a methyl group is added to a cytosine residue on DNA, commonly at the C5 position of a CpG dinucleotide. Three families of DNMTs have been identified: DNMT1, DNMT2, and DNMT3 (comprised of DNMT3A and DNMT3B).DNMT1 is the most abundant DNMT in somatic cells and shows a preference for methylating hemi-methylated DNA. It is considered to be a maintenance DNA methyltransferase that is important in the maintenance of specific patterns of methylation throughout cellular divisions. Methylation of mammalian DNA has long been recognized to play a major role in a number of cellular functions such as embryonic development, genetic imprinting, X chromosome inactivation and the control of gene expression. DNA methylation is generally associated with transcriptional repression.
免疫原 :
This DNMT1 antibody was raised against a peptide corresponding to amino acid residues 637-651 of human DNMT1.
用途 :
ChIP, 免疫组化, 免疫沉淀, 免疫印迹
储存 :
Antibodies in solution can be stored at -20M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
产品引用 :
References: This antibody was used in ChIP and in Re-ChIP assays as described in Schnekenburger, M. et. al. (2007) Mol Cell Biol. 27(20): 7089M-bM-^@M-^S7101.
公司信息
Active Motif
787 Kangqiao Road，Building 10, Suite 202，Pudong District，Shanghai, China
techchina@activemotif.com
http://www.activemotif.com
86-21-20926090 400-018-8123
公司总部: 美国