Geneka Biotechnology

抗体

MBD4抗体(多克隆抗体)

39217

100微克

350美元

多克隆

domestic rabbit

未共轭

MBD4抗体(多克隆抗体)

兔

多克隆

100微克

350美元

IgG

人类

Methylation of mammalian DNA has long been recognized to play a major role in a number of cellular functions such as development and control of gene expression. It is generally associated with the repressive chromatin state. The complex series of events leading to this repressive state involve the coordinated regulation of DNA methyltransferases and two other groups of proteins called the Methyl-CpG binding proteins (MBD proteins) and the Kaiso family of proteins. The MBD family of proteins include MeCP2, MBD1, MBD2, MBD3 and MBD4. MBD4 (methyl-CpG binding domain protein 4) is a thymine glycosylase that recognizes the product of deamination at methyl-CpG sites, as a part of DNA repair system. MBD4 is able to bind the hemimethylated DNA or methyl-CpG TpG mismatches.

This antibody was raised against a mixture of synthetic peptides corresponding to amino acid residues 268-282 and 337-352 of human MBD4.

免疫印迹

Antibodies in solution can be stored at -80M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.