Geneka Biotechnology

抗体

p53抗体(多克隆抗体)

39334

17反应

350美元

多克隆

domestic rabbit

未共轭

免疫沉淀, EMSA, 染色质免疫沉淀

p53抗体(多克隆抗体)

兔

多克隆

17反应

350美元

IgG

人类

p53 is the most important tumor suppressor in the genome. It is responsive to numerous genotoxic stresses, which activates its transcription factor activity, in turn causing cell-cycle arrest by activating expression of p21 Cip/WAF. Mutant p53 that has lost its DNA-binding function interferes with the activity of native p53 and leads to oncogenic transformation. Alternatively, transformation may be caused by overexpression of Mdm2/Hdm2, a ubiquitin ligase specific for p53, which causes its destabilization. Inactivation of p53 is often coincident with hyperactivation of NFM-NM-:B (NFM-NM-:B p50 and NFM-NM-:B p65), both of which serve to inhibit apoptosis.

This p53 antibody was raised against a synthetic peptide corresponding to amino acid residues 367-381 of human p53.

ChIP, EMSA, 免疫沉淀

Antibodies in solution can be stored at -80M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.