Geneka Biotechnology

抗体

NFM-NM p65磷酸化Ser536抗体(多克隆抗体)

39675

100微升

350美元

多克隆

domestic rabbit

未共轭

NFM-NM p65磷酸化Ser536抗体(多克隆抗体)

兔

多克隆

磷酸化

100微升

350美元

血清

人类

NFM-NM-:B p65 (Nuclear factor NF-kappa-B p65 subunit also known as NFM-NM-:B p65 or RelA) is a member of the Rel family of transcription factors that are involved in processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. The Rel family includes c-Rel, RelA (NFM-NM-:B p65, NFM-NM-:B3) and RelB (I-Rel). Rel proteins form dimers with the NFM-NM-:B p50 (proteolytically processed from p105/NFM-NM-:B1)and p52 (proteolytically processed from p100/NFM-NM-:B2) members of the NFM-NM-:B family that bind DNA and activate transcription. The NFM-NM-:B p65/p50 heterodimer is the most abundant form of NFM-NM-:B.NFM-NM-:B signaling is negatively regulated by the sequestration of the NFM-NM-:B complex in the cytoplasm by its association with the IM-NM-:B family of inhibitory proteins. The IM-NM-:B Kinase (IKK) complex is the key enzyme involved in the activation and translocation of NFM-NM-:B. The IKK complex is composed of two catalytic subunits (IKKM-NM-1 and IKKM-NM-2) and a regulatory subunit (IKKM-NM-3). Upon its activation, the IKK complex phosphorylates IM-NM-:B proteins (IM-NM-:BM-NM-1, IM-NM-:BM-NM-1 phospho Ser32, 36), which marks them for ubiquitination and degradation. This enables the NFM-NM-:B complex to translocate to the nucleus where it regulates transcription by binding to DNA.Phosphorylation at serine 536 stimulates acetylation at lysine 310 and interaction with the acetyltransferase CBP. The phosphorylated and acetylated forms show enhanced transcriptional activity.

这NFM-NM p65磷酸化Ser536通过免疫制备抗体a肽含磷酸化丝氨酸536人的NFM-NM p65

DB, 免疫印迹

Antibodies in solution can be stored at -20M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.