Geneka Biotechnology

抗体

Sp1转录因子磷酸化Ser101抗体(多克隆抗体)

39757

100微升

350美元

多克隆

domestic rabbit

未共轭

Sp1转录因子磷酸化Ser101抗体(多克隆抗体)

兔

多克隆

磷酸化

100微升

350美元

IgG

人类

Sp1 (specificity protein 1) is a human transcription factor involved in gene expression in the early development of an organism. The protein is 785 amino acids long, with a molecular weight of 81 kDa. The SP1 transcription factor contains a zinc finger protein motif, by which it binds directly to DNA and enhances gene transcription. Its zinc fingers are of the Cys2/His2 type and bind the consensus sequence 5M-bM-^@M-2-(G/T)GGGCGG(G/A)(G/A)(C/T)-3M-bM-^@M-2 (GC box element). It was discovered in 1983 and has since been modified to form Sp1C, which has a zinc finger protein DNA binding domain. Sp1 contains two SQ/TQ domains, which are found in proteins phosphorylated by the DNA-damage response transducer/effector kinase ATM. Phosphorylation of serine 101 (dependent upon ATM and ATR) is stimulated by double strand DNA breakage (DSBs) as well as by blocks to DNA replication induced by treatment with hydroxyurea or UV irradiation. Sp1 phospho Ser101 co-localizes with ATM phospho Ser1981 at DSBs, suggesting that this phosphorylated version of Sp1 plays a role in double strand break repair.

这Sp1转录因子磷酸化Ser101通过免疫制备抗体a肽含磷酸化丝氨酸101人的Sp1转录因子

DB, 免疫印迹

Antibodies in solution can be stored at -20M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.