PGC1-M-NM-2 (Peroxisome proliferator-activated receptor gamma coactivator 1-beta, PPARGC1B, PERC) is a co-activator of transcription by nuclear receptors and transcription factors. PGC1-M-NM-2 participates in modulating the transcriptional activity of PPAR alpha and gamma, ER alpha, NRF1 and GR. It is likely involved in fat oxidation, non-oxidative glucose metabolism and in the regulation of energy expenditure. Expression of PGC1-M-NM-2 is repressed by saturated fatty acids in skeletal muscle cells and induced by insulin. PGC1-M-NM-2 is down-regulated in type 2 diabetes as well as in pre-diabetics. Allelic variation of PGC1-M-NM-2 may contribute to the pathogenesis of obesity, with the widespread Ala-203 variation being a significant risk factor for the development of this diabetes.
This PGC1-M-NM-2 antibody antibody was raised against a peptide within the N-terminal region of human PGC1-M-NM-2.
Antibodies in solution can be stored at -20M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.