Geneka Biotechnology

抗体

Ubn1抗体(多克隆抗体)

39869

100微升

350美元

多克隆

domestic rabbit

未共轭

Ubn1抗体(多克隆抗体)

兔

多克隆

100微升

350美元

IgG

人类

UBN1 (Ubinuclein 1, also known as HIRA binding protein) is a ubiquitously expressed nuclear protein that acts as a novel regulator of senescence. UBN1 is involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. It is expressed in a number of cancer cell lines and tumors and may be required for replication-independent chromatin assembly. UBN1 is part of a large multi-subunit protein complex that interacts with CEBPA and Epstein-Barr virus BLZF1. It co-localizes with HIRA, PML and SP100 in the PML bodies of senescent cells. When overexpressed, UBN1 accumulates in the nucleus of cells defective for cytokinesis.

This Ubinuclein antibody was raised against a recombinant protein corresponding to amino acids 1-345 of human Ubn1.

免疫印迹

Antibodies in solution can be stored at -20M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.