产品简要
公司名称 :
Active Motif
其他品牌 :
Geneka Biotechnology
产品类型 :
抗体
产品名称 :
EZH2抗体(单克隆抗体)
目录 :
39875
规格 :
100微克
价格 :
350美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
AC22
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫细胞化学, 免疫沉淀, 染色质免疫沉淀 , ChIP-Seq, 核糖核酸免疫沉淀
更多信息或购买 :
Active Motif 产品网页
文章摘录数: 14
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠; 图 4e
Li F, Zeng Z, Xing S, Gullicksrud J, Shan Q, Choi J, et al. Ezh2 programs TFH differentiation by integrating phosphorylation-dependent activation of Bcl6 and polycomb-dependent repression of p19Arf. Nat Commun. 2018;9:5452 pubmed 出版商
  • 核糖核酸免疫沉淀; 人类; 图 6
  • 染色质免疫沉淀 ; 人类; 图 6
Ranzani V, Rossetti G, Panzeri I, Arrigoni A, Bonnal R, Curti S, et al. The long intergenic noncoding RNA landscape of human lymphocytes highlights the regulation of T cell differentiation by linc-MAF-4. Nat Immunol. 2015;16:318-325 pubmed 出版商
  • ChIP-Seq; 人类
  • 染色质免疫沉淀 ; 人类
Englert N, Luo G, Goldstein J, Surapureddi S. Epigenetic modification of histone 3 lysine 27: mediator subunit MED25 is required for the dissociation of polycomb repressive complex 2 from the promoter of cytochrome P450 2C9. J Biol Chem. 2015;290:2264-78 pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠
Wang A, Pan D, Lee Y, Martinez G, Feng X, Dong C. Cutting edge: Smad2 and Smad4 regulate TGF-?-mediated Il9 gene expression via EZH2 displacement. J Immunol. 2013;191:4908-12 pubmed 出版商
  • 染色质免疫沉淀 ; 人类
Bengani H, Mendiratta S, Maini J, Vasanthi D, Sultana H, Ghasemi M, et al. Identification and Validation of a Putative Polycomb Responsive Element in the Human Genome. PLoS ONE. 2013;8:e67217 pubmed 出版商
  • 免疫沉淀; 人类; 5 ul
Rossetto C, Tarrant Elorza M, Pari G. Cis and trans acting factors involved in human cytomegalovirus experimental and natural latent infection of CD14 (+) monocytes and CD34 (+) cells. PLoS Pathog. 2013;9:e1003366 pubmed 出版商
  • 免疫印迹; 人类
Lin S, Shen H, Li J, Tang S, Gu Y, Chen Z, et al. Proteomic and functional analyses reveal the role of chromatin reader SFMBT1 in regulating epigenetic silencing and the myogenic gene program. J Biol Chem. 2013;288:6238-47 pubmed 出版商
  • 染色质免疫沉淀 ; 人类
  • 免疫印迹; 人类
Murata T, Kondo Y, Sugimoto A, Kawashima D, Saito S, Isomura H, et al. Epigenetic histone modification of Epstein-Barr virus BZLF1 promoter during latency and reactivation in Raji cells. J Virol. 2012;86:4752-61 pubmed 出版商
Huang S, Fantini D, Merrill B, Bagchi S, Guzman G, Raychaudhuri P. DDB2 Is a Novel Regulator of Wnt Signaling in Colon Cancer. Cancer Res. 2017;77:6562-6575 pubmed 出版商
Xia L, Huang W, Bellani M, Seidman M, Wu K, Fan D, et al. CHD4 Has Oncogenic Functions in Initiating and Maintaining Epigenetic Suppression of Multiple Tumor Suppressor Genes. Cancer Cell. 2017;31:653-668.e7 pubmed 出版商
Lawrence C, Baldwin A. Non-Canonical EZH2 Transcriptionally Activates RelB in Triple Negative Breast Cancer. PLoS ONE. 2016;11:e0165005 pubmed 出版商
Akizu N, García M, Estarás C, Fueyo R, Badosa C, de la Cruz X, et al. EZH2 regulates neuroepithelium structure and neuroblast proliferation by repressing p21. Open Biol. 2016;6:150227 pubmed 出版商
Mitić T, Caporali A, Floris I, Meloni M, Marchetti M, Urrutia R, et al. EZH2 modulates angiogenesis in vitro and in a mouse model of limb ischemia. Mol Ther. 2015;23:32-42 pubmed 出版商
Woellmer A, Arteaga Salas J, Hammerschmidt W. BZLF1 governs CpG-methylated chromatin of Epstein-Barr Virus reversing epigenetic repression. PLoS Pathog. 2012;8:e1002902 pubmed 出版商
产品信息
目录代码 :
39875
产品名称 :
EZH2抗体(单克隆抗体)
宿主物种 :
小鼠
克隆性 :
单克隆
规格 :
100微克
标价 :
350美元
克隆 :
AC22
抗体亚型 :
IgG2a
交叉活性 :
人类, 小鼠
背景 :
EZH2 M-bM-^@M-^S (Enhancer of Zeste homolog 2, also designated Enx1 and SETDB1) is a human homolog of the Drosophila Polycomb-group protein Enhancer of Zeste protein. It contains a SET domain that catalyzes the methylation of histone H3 at lysine 27 (Histone H3 Lys27 monomethylated, dimethylated and trimethylated). Polycomb-group proteins repress gene expression by binding to chromatin and locally altering chromatin structure. EZH2, BMI-1 and Suz12 are present in the PRC2 and PRC3 protein complexes that function as mediators of epigenetic transcriptional silencing. EZH2 associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. EZH2 may play a role in the hematopoietic and central nervous systems. Deregulation of EZH2 is linked to a variety of cancers.
免疫原 :
This EZH2 antibody was raised against a recombinant protein corresponding to amino acids 353-451 of human EZH2.
用途 :
ChIP, IF, 免疫沉淀
储存 :
Antibodies in solution can be stored at -20M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
产品引用 :
References: This antibody has been used in the following references: ChIP: Bracken AP et al. (2007) Genes Dev 21: 535-540; Pasini D et al. (2007) Molec Cell Biol 27: 3769-3779; Pasini D et al. (2008) Genes Dev 22: 1345-1355.IP: Pasini D et al. (2008) Genes Dev 22: 1345-1355.
更多信息或购买 :
Active Motif 产品网页
公司信息
Active Motif
787 Kangqiao Road，Building 10, Suite 202，Pudong District，Shanghai, China
techchina@activemotif.com
http://www.activemotif.com
86-21-20926090 400-018-8123
公司总部: 美国