产品简要
公司名称 :
Active Motif
其他品牌 :
Geneka Biotechnology
产品类型 :
抗体
产品名称 :
核纤层蛋白A/C R453W抗体(单克隆抗体)
目录 :
39959
规格 :
100微克
价格 :
350美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
12A-2F5
反应物种 :
人类
应用 :
免疫印迹, 免疫细胞化学, 免疫沉淀
更多信息或购买 :
产品信息
目录代码 :
39959
产品名称 :
核纤层蛋白A/C R453W抗体(单克隆抗体)
宿主物种 :
小鼠
克隆性 :
单克隆
规格 :
100微克
标价 :
350美元
克隆 :
12A-2F5
抗体亚型 :
IgG1k
交叉活性 :
人类
背景 :
Nuclear lamins are intermediate filament proteins that are the major structural component of the nuclear lamina on the inner surface of the nuclear envelope. Lamin A and Lamin C are splice variants of the Lamin A gene. Lamin A/C (CDCD1, LMN1, EMD2) expression is a hallmark of embryonic stem cell differentiation. In addition to adding structural integrity to the nucleus, lamins contribute to the makeup of the nuclear matrix. Lamins also help organize interphase chromatin through interactions with several chromatin proteins, including histones and Lap2, such that alteration in lamin organization (laminopathy) results in disruption of DNA replication, transcription and RNA processing. The R453W mutation is one of the most common causes of autosomal dominant Emery-Dreifuss muscular dystrophy (EDMD).
免疫原 :
This Lamin A/C R453W antibody was raised against a peptide consisting of amino acids 449-457 of human Lamin A/C containing the R453W substitution.
用途 :
IF, 免疫沉淀, 免疫印迹
储存 :
Antibodies in solution can be stored at -20M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
产品引用 :
References: This antibody has been used in the following references:IF, IP & WB: Roblek M et al (2010) PLoS One 5: e10604.
更多信息或购买 :
公司信息
Active Motif
787 Kangqiao Road,Building 10, Suite 202,Pudong District,Shanghai, China
techchina@activemotif.com
http://www.activemotif.com
86-21-20926090 400-018-8123
公司总部: 美国