Geneka Biotechnology

抗体

IKKM-NM抗体(单克隆抗体)

40907

100微克

350美元

单克隆

小鼠

未共轭

10A9B6

免疫印迹, 免疫沉淀

IKKM-NM抗体(单克隆抗体)

小鼠

单克隆

100微克

350美元

10A9B6

IgG1

人类

IKKM-NM-2 (IM-NM-:B Kinase beta subunit) M-bM-^@M-^S The IM-NM-:B Kinase (IKK) complex is the key enzyme involved in the activation and translocation of NFM-NM-:B (NFM-NM-:B p50 and NFM-NM-:B p65). The IKK complex is composed of two catalytic subunits (IKKM-NM-1 and IKKM-NM-2) and a regulatory subunit (IKKM-NM-3).NFM-NM-:B signaling is negatively regulated by the sequestration of the NFM-NM-:B complex in the cytoplasm by its association with the IM-NM-:B family of inhibitory proteins. Upon its activation, the IKK complex phosphorylates IM-NM-:BM-NM-1 at Ser32 and Ser36. This results ultimately in the degradation of IM-NM-:B and the activation and nuclear translocation of NFM-NM-:B.While both IKK-alpha and IKK-beta subunits are Ser/Thr kinases, IKK beta appears to be the principal kinase, as IKKM-NM-1 is not required for activation of the IKK complex and the subsequent degradation of IM-NM-:BM-NM-1. Once activated, IKKM-NM-2 autophosphorylates, which decreases IKK activity, thereby preventing a prolonged activation of inflammation.

This antibody was raised against a 6xHis tag full-length protein corresponding to human IKKM-NM-2.

免疫沉淀, 免疫印迹

Antibodies in solution can be stored at -80M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.