Geneka Biotechnology

抗体

p73M-NM抗体(单克隆抗体)

40973

100微克

350美元

单克隆

小鼠

未共轭

38C674

p73M-NM抗体(单克隆抗体)

小鼠

单克隆

100微克

350美元

38C674

IgG1

人类

p73M-NM-^TN is a member of the p53 protein family which includes p53 as well as p63. Whereas p53 transactivates the retinoblastoma gene, p63 and p73 induce the cyclin-dependent kinase inhibitor p57 to maintain Rb in an active, hypophosphorylated state. p73M-NM-^TN inhibits the functions of the p53 family in differentiation control, prevents myogenic differentiation, and enables cooperating oncogenes to transform myoblasts to tumorigenicity. p73M-NM-^TN is frequently overexpressed in rhabdomyosarcoma and is essential for tumor progression in vivo. These findings establish differentiation control as a key tumor suppressor activity of the p53 family.

This p73DN antibody was raised against a peptide corresponding to amino acid residues 2-13 of human p73M-NM-^TN.

免疫印迹

Antibodies in solution can be stored at -80M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.