免疫印迹, 免疫细胞化学, 免疫沉淀, EMSA, 染色质免疫沉淀
ER-M-NM-1 (estrogen receptor M-NM-1) is a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding and activation of transcription. ER-M-NM-1 localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer and osteoporosis.
This ER-alpha antibody was raised against a peptide within the C-terminal region of human Estrogen Receptor alpha.
ChIP, EMSA, IF, 免疫沉淀, 免疫印迹
Antibodies in solution can be stored at -20M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
References: This antibody has been used in the following references: ChIP: Welboren WJ et al. (2009) EMBO J 28: 1418-1428.