产品简要
公司名称 :
Active Motif
其他品牌 :
Geneka Biotechnology
产品类型 :
抗体
产品名称 :
组蛋白H3K36me3抗体(多克隆抗体)
目录 :
61101
规格 :
100微升
价格 :
350美元
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 非洲爪蛙
应用 :
免疫印迹, 免疫细胞化学, 免疫沉淀, 染色质免疫沉淀 , ChIP-Seq
更多信息或购买 :
Active Motif 产品网页
文章摘录数: 13
出版应用/物种/样本/稀释参考文献
  • ChIP-Seq; 人类; 图 5b
Stewart E, McEvoy J, Wang H, Chen X, Honnell V, Ocarz M, et al. Identification of Therapeutic Targets in Rhabdomyosarcoma through Integrated Genomic, Epigenomic, and Proteomic Analyses. Cancer Cell. 2018;34:411-426.e19 pubmed 出版商
  • ChIP-Seq; 小鼠; 表 1
  • 免疫印迹; 小鼠; 图 6
  • 免疫印迹; 非洲爪蛙; 图 1
Powers N, Parvanov E, Baker C, Walker M, Petkov P, Paigen K. The Meiotic Recombination Activator PRDM9 Trimethylates Both H3K36 and H3K4 at Recombination Hotspots In Vivo. PLoS Genet. 2016;12:e1006146 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 图 2a
  • 免疫细胞化学; 人类; 1:1000; 图 s3d
  • 免疫印迹; 人类; 图 1a
Fang D, Gan H, Lee J, Han J, Wang Z, Riester S, et al. The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas. Science. 2016;352:1344-8 pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠; 图 s11b
  • 免疫印迹; 小鼠; 图 s8a
Lu C, Jain S, Hoelper D, Bechet D, Molden R, Ran L, et al. Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape. Science. 2016;352:844-9 pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠; 图 6
Lee B, Wu C, Lin Y, Park S, Wei L. Synergistic activation of Arg1 gene by retinoic acid and IL-4 involves chromatin remodeling for transcription initiation and elongation coupling. Nucleic Acids Res. 2016;44:7568-79 pubmed 出版商
Erkek S, Johann P, Finetti M, Drosos Y, Chou H, Zapatka M, et al. Comprehensive Analysis of Chromatin States in Atypical Teratoid/Rhabdoid Tumor Identifies Diverging Roles for SWI/SNF and Polycomb in Gene Regulation. Cancer Cell. 2018;: pubmed 出版商
Fang D, Wang H, Zhang Z. Probing the Function of Oncohistones Using Mutant Transgenes and Knock-In Mutations. Methods Mol Biol. 2018;1832:339-356 pubmed 出版商
Chen X, Zhang M, Gan H, Wang H, Lee J, Fang D, et al. A novel enhancer regulates MGMT expression and promotes temozolomide resistance in glioblastoma. Nat Commun. 2018;9:2949 pubmed 出版商
Chiang Y, Park I, Terzo E, Tripathi D, Mason F, Fahey C, et al. SETD2 Haploinsufficiency for Microtubule Methylation Is an Early Driver of Genomic Instability in Renal Cell Carcinoma. Cancer Res. 2018;78:3135-3146 pubmed 出版商
Janevska S, Baumann L, Sieber C, Munsterkotter M, Ulrich J, Kämper J, et al. Elucidation of the Two H3K36me3 Histone Methyltransferases Set2 and Ash1 in Fusarium fujikuroi Unravels Their Different Chromosomal Targets and a Major Impact of Ash1 on Genome Stability. Genetics. 2018;208:153-171 pubmed 出版商
Pünzeler S, Link S, Wagner G, Keilhauer E, Kronbeck N, Spitzer R, et al. Multivalent binding of PWWP2A to H2A.Z regulates mitosis and neural crest differentiation. EMBO J. 2017;36:2263-2279 pubmed 出版商
Aldiri I, Xu B, Wang L, Chen X, Hiler D, Griffiths L, et al. The Dynamic Epigenetic Landscape of the Retina During Development, Reprogramming, and Tumorigenesis. Neuron. 2017;94:550-568.e10 pubmed 出版商
Ho T, Park I, Zhao H, Tong P, Champion M, Yan H, et al. High-resolution profiling of histone h3 lysine 36 trimethylation in metastatic renal cell carcinoma. Oncogene. 2016;35:1565-74 pubmed 出版商
产品信息
目录代码 :
61101
产品名称 :
组蛋白H3K36me3抗体(多克隆抗体)
宿主物种 :
兔
克隆性 :
多克隆
抗原修饰 :
Methylated
规格 :
100微升
标价 :
350美元
抗体亚型 :
IgG
交叉活性 :
Human, Other (Wide Range)
背景 :
Histone H3 is one of the core components of the nucleosome. The nucleosome is the smallest subunit of chromatin and consists of 147 base pairs of DNA wrapped around an octamer of core histone proteins (two each of Histone H2A, Histone H2B, Histone H3 and Histone H4). Chromatin is subject to a variety of chemical modifications, including post-translational modifications of the histone proteins and the methylation of cytosine residues in the DNA. Reported histone modifications include acetylation, methylation, phosphorylation, ubiquitylation, glycosylation, ADP-ribosylation, carbonylation and SUMOylation; these modifications play a major role in regulating gene expression.The methylation of histones can occur on two different residues: arginine or lysine. Histone methylation can be associated with transcriptional activation or repression, depending on the methylated residue. Histone H3 is methylated at lysine 36 by the Set2 (yeast) and NSD1 (mammals) methyltransferases. Dimethylation of lysine 36 of histone H3 is involved with transcriptional elongation by RNA pol II holoenzyme and is a marker of transcribed genes.
免疫原 :
这组蛋白H3三甲基化Lys36通过免疫制备抗体a肽含三甲基化Lys36人的组蛋白H3
用途 :
ChIP, ChIP-chip, ChIP-Seq, DB, IP, WB
储存 :
Antibodies in solution can be stored at -20M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
更多信息或购买 :
Active Motif 产品网页
公司信息
Active Motif
787 Kangqiao Road，Building 10, Suite 202，Pudong District，Shanghai, China
techchina@activemotif.com
http://www.activemotif.com
86-21-20926090 400-018-8123
公司总部: 美国