Geneka Biotechnology

抗体

Notch1抗体(单克隆抗体)

61147

100微克

350美元

单克隆

大鼠

未共轭

ICN 5B5

人类, 大鼠

Notch1抗体(单克隆抗体)

大鼠

单克隆

100微克

350美元

ICN 5B5

IgG2b

人类, 大鼠

Notch1 is a member of the Notch family of receptors, which make up a highly conserved cell signaling system. Notch1 functions as a ligand-activated transcription factor that directly transduces extracellular signals in the cell surface into changes in gene expression in the nucleus. Notch1 is membrane bound, serving as an extracellular receptor for the Delta and Serrate family of ligands. Upon activation, the intracellular domain is cleaved and rapidly translocates into the nucleus where it forms a transcriptional complex with the RBP-J DNA binding protein and activates gene expression via recruitment of co-activators of the MAML family. Notch receptors play a critical role in cell fate specification during development and participate in multiple biological processes. Notch signaling is required for undifferentiated embryonic stem cells (ESCs) to participate in the formation of all three embryonic germ layers.

This Notch1 antibody was raised against a recombinant protein corresponding to the intracellular domain of human Notch1.

免疫印迹

Antibodies in solution can be stored at -20M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.