Geneka Biotechnology

抗体

B细胞淋巴瘤6蛋白抗体(单克隆抗体)

61193

100微克

350美元

单克隆

小鼠

未共轭

IG191E

免疫印迹, 免疫组化

B细胞淋巴瘤6蛋白抗体(单克隆抗体)

小鼠

单克隆

100微克

350美元

IG191E

IgG1

人类

Bcl6 (B-cell lymphoma 6 protein, Bcl5, LAZ3, ZBTB27, ZNF51) is sequence-specific transcriptional repressor that is required for the formation of lymph node germinal centers (GC). Bcl6 is a member of the BTB-POZ family of transcriptional regulators and contains six Kruppel-type zinc fingers. The POZ domain in the amino terminus of Bcl6 is involved in the recruitment of corepressor proteins including NCoR, BCoR, SMRT, Mi-2/NURD and several HDACs. Bcl6 promotes proliferative expansion of B-cells in the germinal center through repression of genes regulating cell cycle and differentiation. Bcl6 also suppresses the DNA damage response, to prevent class-switch recombination being repaired. Unregulated expression of Bcl6 is involved in the development of many B-cell lymphomas.

This Bcl6 antibody was raised against a full-length protein corresponding to human Bcl6.

免疫组化, 免疫印迹

Antibodies in solution can be stored at -20M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

References: This antibody has been used in the following references: IHC: Garcia JF et al (2006) J Histochem Cytochem 54: 31-38; Garcia JF et al (2006) Haematologica 91: 467-474. WB: Garcia JF et al (2006) J Histochem Cytochem 54: 31-38.