Geneka Biotechnology

抗体

NR2C2抗体(多克隆抗体)

61279

100微升

350美元

多克隆

domestic rabbit

未共轭

NR2C2抗体(多克隆抗体)

兔

多克隆

100微升

350美元

IgG

人类

NR2C2 (nuclear receptor subfamily 2, group C, member 2, TR4, TAK1, TR2R1, hTAK1) is an orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear recptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation.

This NR2C2 antibody was raised against a peptide within the N-terminal region of human NR2C2.

免疫印迹

Antibodies in solution can be stored at -20M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.