产品简要
公司名称 :
Active Motif
其他品牌 :
Geneka Biotechnology
产品类型 :
抗体
产品名称 :
MeCP2抗体(单克隆抗体)
目录 :
61285
规格 :
100微克
价格 :
350美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
4B4
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 染色质免疫沉淀 , ChIP-Seq
更多信息或购买 :
Active Motif 产品网页
文章摘录数: 3
出版应用/物种/样本/稀释参考文献
  • ChIP-Seq; 小鼠; 图 3k
Liu Y, Zhang B, Meng X, Korn M, Parent J, Lu L, et al. UHRF2 regulates local 5-methylcytosine and suppresses spontaneous seizures. Epigenetics. 2017;12:551-560 pubmed 出版商
  • 免疫组化; 大鼠; 1:200
Hoefflin S, Carter D. Neuronal expression of SOX2 is enriched in specific hypothalamic cell groups. J Chem Neuroanat. 2014;61-62:153-60 pubmed 出版商
Tai D, Liu Y, Hsu W, Ma Y, Cheng S, Liu S, et al. MeCP2 SUMOylation rescues Mecp2-mutant-induced behavioural deficits in a mouse model of Rett syndrome. Nat Commun. 2016;7:10552 pubmed 出版商
产品信息
目录代码 :
61285
产品名称 :
MeCP2抗体(单克隆抗体)
宿主物种 :
小鼠
克隆性 :
单克隆
规格 :
100微克
标价 :
350美元
克隆 :
4B4
抗体亚型 :
IgG2a
交叉活性 :
人类, 小鼠, 大鼠
背景 :
Methylation of mammalian DNA has long been recognized to play a major role in a number of cellular functions such as development and control of gene expression. It is generally associated with the repressive chromatin state. The complex series of events leading to this repressive state involve the coordinated regulation of DNA methyltransferases and two other groups of proteins called the Methyl-CpG binding proteins (MBD proteins) and the Kaiso family of proteins. The MBD family of proteins include MeCP2, MBD1, MBD2, MBD3 and MBD4. MeCP2 (methyl CpG binding protein 2, PPMX, MRX16, MRX79, MRXSL, AUTSX3, MRXS13) is a chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A.
免疫原 :
This MeCP2 antibody was raised against a full-length protein corresponding to rat MeCP2.
用途 :
ChIP, IF, 免疫组化, 免疫沉淀, 免疫印迹
储存 :
Antibodies in solution can be stored at -20M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
产品引用 :
References: The use of this antibody is described in the following references: ChIP, IP, IF, IHC & WB: Jost KL, et al. (2011) PLoS One 6 (11): e26499
更多信息或购买 :
Active Motif 产品网页
公司信息
Active Motif
787 Kangqiao Road，Building 10, Suite 202，Pudong District，Shanghai, China
techchina@activemotif.com
http://www.activemotif.com
86-21-20926090 400-018-8123
公司总部: 美国