Geneka Biotechnology

抗体

Trrap antibody (mAb)

61335

100微克

350美元

单克隆

小鼠

未共轭

2TRR-1B3

人类, 小鼠

免疫沉淀, 染色质免疫沉淀

Trrap antibody (mAb)

小鼠

单克隆

100微克

350美元

2TRR-1B3

IgG2a

人类, 小鼠

Trrap (transformation/transcription domain-associated protein) is an adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. Probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Probably not required in the steps following histone acetylation in processes of transcription activation. May be required for the mitotic checkpoint and normal cell cycle progression.

This antibody was raised against a synthetic peptide corresponding to amino acid residue(s) 2023-2042 of human Trrap.

ChIP, 免疫沉淀

Antibodies in solution can be stored at -20M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

References: The use of this antibody is described in the following References:ChIP: Szutorisz, H. et al. (2005) Mol Cell Biol 25:1804-1820.IP: Krebs, A.R., et al. (2010) EMBO Reports 11:541-547.