Geneka Biotechnology

抗体

Histone H3K4K9K18 (pan-biotinylated) antibody (pAb)

61391

100微升

350美元

多克隆

domestic rabbit

生物素

免疫印迹, 免疫细胞化学

Histone H3K4K9K18 (pan-biotinylated) antibody (pAb)

兔

多克隆

生物素

100微升

350美元

IgG

人类

Histone H3 is one of the core components of the nucleosome. The nucleosome is the smallest subunit of chromatin and consists of 147 base pairs of DNA wrapped around an octamer of core histone proteins (two each of Histone H2A, Histone H2B, Histone H3 and Histone H4). Histone H1 is a linker histone, present at the interface between the nucleosome core and DNA entry/exit points. Histone H1 is responsible for establishing higher-order chromatin structure.Chromatin is subject to a variety of chemical modifications, including post-translational modifications of the histone proteins and the methylation of cytosine residues in the DNA. Reported histone modifications include acetylation, methylation, phosphorylation, ubiquitylation, glycosylation, ADP-ribosylation, carbonylation, SUMOylation and biotinylation; these modifications play a major role in regulating gene expression.The biotinylation of Histone H3 on Lys4, Lys9 and Lys18 has been reported to be enriched in repeat regions and may participate in repression of transcriptionally competent genes.

This antibody was raised against a synthetic peptide containing biotin-Lys 4 of human Histone H3.

DB, IF, 免疫印迹

Antibodies in solution can be stored at -20M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

References: The use of this antibody is described in the following Reference:WB, IF & DB: Kobza, K. et al. (2005) FEBS J 272:4249-4259.