产品简要
公司名称 :
Addgene
产品类型 :
cDNA
产品名称 :
pBabe-Puro-BRAF-V600E
目录 :
15269
更多信息或购买 :
文章摘录数: 21
参考文献
Chen J, Hug C, Reyes J, Tian C, Gerosa L, Fr xf6 hlich F, et al. Multi-range ERK responses shape the proliferative trajectory of single cells following oncogene induction. Cell Rep. 2023;42:112252 pubmed 出版商
Prieto Garcia C, Hartmann O, Reissland M, Braun F, Bozkurt S, Pahor N, et al. USP28 enables oncogenic transformation of respiratory cells, and its inhibition potentiates molecular therapy targeting mutant EGFR, BRAF and PI3K. Mol Oncol. 2022;: pubmed 出版商
Schaufler D, Ast D, Tumbrink H, Abedpour N, Maas L, Schwäbe A, et al. Clonal dynamics of BRAF-driven drug resistance in EGFR-mutant lung cancer. NPJ Precis Oncol. 2021;5:102 pubmed 出版商
Buj R, Leon K, Anguelov M, Aird K. Suppression of p16 alleviates the senescence-associated secretory phenotype. Aging (Albany NY). 2021;13:3290-3312 pubmed 出版商
Tago K, Funakoshi Tago M, Ohta S, Kawata H, Saitoh H, Horie H, et al. Oncogenic Ras mutant causes the hyperactivation of NF-κB via acceleration of its transcriptional activation. Mol Oncol. 2019;13:2493-2510 pubmed 出版商
Wang X, Xu X, Peng C, Qin Y, Gao T, Jing J, et al. BRAFV600E-induced KRT19 expression in thyroid cancer promotes lymph node metastasis via EMT. Oncol Lett. 2019;18:927-935 pubmed 出版商
Robb R, Yang L, Shen C, Wolfe A, Webb A, Zhang X, et al. Inhibiting BRAF Oncogene-Mediated Radioresistance Effectively Radiosensitizes BRAFV600E-Mutant Thyroid Cancer Cells by Constraining DNA Double-Strand Break Repair. Clin Cancer Res. 2019;: pubmed 出版商
Ng M, Gan Y, Hagen T. Characterisation of cellular effects of Burkholderia pseudomallei cycle inhibiting factor (Cif). Biol Open. 2018;7: pubmed 出版商
Liu R, Zhang T, Zhu G, Xing M. Regulation of mutant TERT by BRAF V600E/MAP kinase pathway through FOS/GABP in human cancer. Nat Commun. 2018;9:579 pubmed 出版商
Xu Y, Wang X, Chen Y, Chen S, Yang X, Sun Y, et al. Integration of Receptor Tyrosine Kinases Determines Sensitivity to PI3K?-selective Inhibitors in Breast Cancer. Theranostics. 2017;7:974-986 pubmed 出版商
Welsch M, Kaplan A, Chambers J, Stokes M, Bos P, Zask A, et al. Multivalent Small-Molecule Pan-RAS Inhibitors. Cell. 2017;168:878-889.e29 pubmed 出版商
Ng M, Wang M, Casey P, Gan Y, Hagen T. Activation of MAPK/ERK signaling by Burkholderia pseudomallei cycle inhibiting factor (Cif). PLoS ONE. 2017;12:e0171464 pubmed 出版商
Kawakami H, Huang S, Pal K, Dutta S, Mukhopadhyay D, Sinicrope F. Mutant BRAF Upregulates MCL-1 to Confer Apoptosis Resistance that Is Reversed by MCL-1 Antagonism and Cobimetinib in Colorectal Cancer. Mol Cancer Ther. 2016;15:3015-3027 pubmed
Gupta R, Forloni M, Bisserier M, Dogra S, Yang Q, Wajapeyee N. Interferon alpha-inducible protein 6 regulates NRASQ61K-induced melanomagenesis and growth. elife. 2016;5: pubmed 出版商
Tachibana N, Cantrup R, Dixit R, Touahri Y, Kaushik G, Zinyk D, et al. Pten Regulates Retinal Amacrine Cell Number by Modulating Akt, Tgf?, and Erk Signaling. J Neurosci. 2016;36:9454-71 pubmed 出版商
Hafner M, Niepel M, Chung M, Sorger P. Growth rate inhibition metrics correct for confounders in measuring sensitivity to cancer drugs. Nat Methods. 2016;13:521-7 pubmed 出版商
Lakiotaki E, Levidou G, Angelopoulou M, Adamopoulos C, Pangalis G, Rassidakis G, et al. Potential role of AKT/mTOR signalling proteins in hairy cell leukaemia: association with BRAF/ERK activation and clinical outcome. Sci Rep. 2016;6:21252 pubmed 出版商
Hellesøy M, Lorens J. Cellular context-mediated Akt dynamics regulates MAP kinase signaling thresholds during angiogenesis. Mol Biol Cell. 2015;26:2698-711 pubmed 出版商
Forloni M, Dogra S, Dong Y, Conte D, Ou J, Zhu L, et al. miR-146a promotes the initiation and progression of melanoma by activating Notch signaling. elife. 2014;3:e01460 pubmed 出版商
Raabe E, Lim K, Kim J, Meeker A, Mao X, Nikkhah G, et al. BRAF activation induces transformation and then senescence in human neural stem cells: a pilocytic astrocytoma model. Clin Cancer Res. 2011;17:3590-9 pubmed 出版商
Boehm J, Zhao J, Yao J, Kim S, Firestein R, Dunn I, et al. Integrative genomic approaches identify IKBKE as a breast cancer oncogene. Cell. 2007;129:1065-79 pubmed
产品信息
目录号 :
15269
产品名称 :
pBabe-Puro-BRAF-V600E
文章 :
doi10.1016/j.cell.2007.03.052
id1529
pubmed_id17574021
细菌的抗性 :
氨苄西林
克隆 :
backbonepBabe-puro
backbone_mutation
backbone_origin
backbone_size5100
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
Retroviral
生长株 :
Retroviral expression of BRAF V600E (the V600E mutation has been found in cancer patients, confers increased kinase activity, and is transforming)
起源 :
37
主要研究者 :
alt_names
cloning
clone_methodRestriction Enzyme
cloning_site_3HindIII
cloning_site_5HindIII
promoter
sequencing_primer_3
sequencing_primer_5pBABE 5'
site_3_destroyed1
site_5_destroyed1
entrez_gene
aliasesB-RAF1, B-raf, BRAF-1, BRAF1, NS7, RAFB1
geneBRAF
id673
genbank_ids
mutationValine 600 to Glutamate (mutation has been found in cancer patients, confers increased kinase activity, and is transforming)
nameBRAF
shRNA_sequence
size2400
species
9606
Homo sapiens
tags
locationC terminal on insert
tagMyc
locationC terminal on insert
tagHis
抗性标记物 :
184
标签 :
High Copy
更多信息或购买 :
公司信息
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
公司总部: 美国