参考文献 |
---|
Sgro A, Cursons J, Waryah C, Woodward E, Foroutan M, Lyu R, et al. Epigenetic reactivation of tumor suppressor genes with CRISPRa technologies as precision therapy for hepatocellular carcinoma. Clin Epigenetics. 2023;15:73 pubmed 出版商
|
Huang W, Sakuma S, Tottori N, Sugano S, Yamanishi Y. Viscosity-aided electromechanical poration of cells for transfecting molecules. Lab Chip. 2022;22:4276-4291 pubmed 出版商
|
Chen W, Gaidukov L, Lai Y, Wu M, Cao J, Gutbrod M, et al. A synthetic transcription platform for programmable gene expression in mammalian cells. Nat Commun. 2022;13:6167 pubmed 出版商
|
Chan W, Coughlan H, Chen Y, Keenan C, Smyth G, Perkins A, et al. Activation of stably silenced genes by recruitment of a synthetic de-methylating module. Nat Commun. 2022;13:5582 pubmed 出版商
|
Leung H, Foo G, VanDongen A. Arc Regulates Transcription of Genes for Plasticity, Excitability and Alzheimer's Disease. Biomedicines. 2022;10: pubmed 出版商
|
Wang J, Wang A, Tian K, Hua X, Zhang B, Zheng Y, et al. A Ctnnb1 enhancer regulates neocortical neurogenesis by controlling the abundance of intermediate progenitors. Cell Discov. 2022;8:74 pubmed 出版商
|
Wang K, Escobar M, Li J, Mahata B, Goell J, Shah S, et al. Systematic comparison of CRISPR-based transcriptional activators uncovers gene-regulatory features of enhancer-promoter interactions. Nucleic Acids Res. 2022;50:7842-7855 pubmed 出版商
|
Ma H, de Zwaan E, Guo Y, Cejas P, Thiru P, van de Bunt M, et al. The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes. Cell Stem Cell. 2022;29:795-809.e11 pubmed 出版商
|
Wang C, Qu Y, Cheng J, Hughes N, Zhang Q, Wang M, et al. dCas9-based gene editing for cleavage-free genomic knock-in of long sequences. Nat Cell Biol. 2022;24:268-278 pubmed 出版商
|
Fennell K, Vassiliadis D, Lam E, Martelotto L, Balic J, Hollizeck S, et al. Non-genetic determinants of malignant clonal fitness at single-cell resolution. Nature. 2022;601:125-131 pubmed 出版商
|
Wang C, Xia Q, Zhang Q, Qu Y, Su S, Cheng J, et al. CRISPR-Cas12a System With Synergistic Phage Recombination Proteins for Multiplex Precision Editing in Human Cells. Front Cell Dev Biol. 2021;9:719705 pubmed 出版商
|
Zeng J, Xu H, Huang C, Sun Y, Xiao H, Yu G, et al. CD46 splice variant enhances translation of specific mRNAs linked to an aggressive tumor cell phenotype in bladder cancer. Mol Ther Nucleic Acids. 2021;24:140-153 pubmed 出版商
|
Zhang X, Lv S, Luo Z, Hu Y, Peng X, Lv J, et al. MiniCAFE, a CRISPR/Cas9-based compact and potent transcriptional activator, elicits gene expression in vivo. Nucleic Acids Res. 2021;49:4171-4185 pubmed 出版商
|
Lu X, Chen X, Forney C, Donmez O, Miller D, Parameswaran S, et al. Global discovery of lupus genetic risk variant allelic enhancer activity. Nat Commun. 2021;12:1611 pubmed 出版商
|
Wang C, Cheng J, Zhang Q, Hughes N, Xia Q, Winslow M, et al. Microbial single-strand annealing proteins enable CRISPR gene-editing tools with improved knock-in efficiencies and reduced off-target effects. Nucleic Acids Res. 2021;49:e36 pubmed 出版商
|
Hamann M, Ehmele P, Verdikt R, Bialek Waldmann J, Virdi S, Gunther T, et al. Transcriptional behavior of the HIV-1 promoter in context of the BACH2 prominent proviral integration gene. Virus Res. 2021;293:198260 pubmed 出版商
|
Velazquez J, LeGraw R, Moghadam F, Tan Y, Kilbourne J, Maggiore J, et al. Gene Regulatory Network Analysis and Engineering Directs Development and Vascularization of Multilineage Human Liver Organoids. Cell Syst. 2021;12:41-55.e11 pubmed 出版商
|
Ruan X, Li P, Ma Y, Jiang C, Chen Y, Shi Y, et al. Identification of human long noncoding RNAs associated with nonalcoholic fatty liver disease and metabolic homeostasis. J Clin Invest. 2021;131: pubmed 出版商
|
Ferry Q, Fulga T. Controlling the Activity of CRISPR Transcriptional Regulators with Inducible sgRNAs. Methods Mol Biol. 2021;2162:153-184 pubmed 出版商
|
Dai Y, Luo W, Yue X, Ma W, Wang J, Chang J. Identification and characterization of a new isoform of small GTPase RhoE. Commun Biol. 2020;3:572 pubmed 出版商
|
Hsu M, Liao H, Truong V, Huang K, Yu F, Chen H, et al. CRISPR-based Activation of Endogenous Neurotrophic Genes in Adipose Stem Cell Sheets to Stimulate Peripheral Nerve Regeneration. Theranostics. 2019;9:6099-6111 pubmed 出版商
|
Cheng T, Li S, Yuan B, Wang X, Zhou W, Qiu Z. Expanding C-T base editing toolkit with diversified cytidine deaminases. Nat Commun. 2019;10:3612 pubmed 出版商
|
Kunii A, Hara Y, Takenaga M, Hattori N, Fukazawa T, Ushijima T, et al. Three-Component Repurposed Technology for Enhanced Expression: Highly Accumulable Transcriptional Activators via Branched Tag Arrays. CRISPR J. 2018;1:337-347 pubmed 出版商
|
Yamazaki T, Fujikawa C, Kubota A, Takahashi A, Hirose T. CRISPRa-mediated NEAT1 lncRNA upregulation induces formation of intact paraspeckles. Biochem Biophys Res Commun. 2018;504:218-224 pubmed 出版商
|
Nakade S, Mochida K, Kunii A, Nakamae K, Aida T, Tanaka K, et al. Biased genome editing using the local accumulation of DSB repair molecules system. Nat Commun. 2018;9:3270 pubmed 出版商
|
Zhao Z, Sentürk N, Song C, Grummt I. lncRNA PAPAS tethered to the rDNA enhancer recruits hypophosphorylated CHD4/NuRD to repress rRNA synthesis at elevated temperatures. Genes Dev. 2018;32:836-848 pubmed 出版商
|
Lange U, Bialek J, Walther T, Hauber J. Pinpointing recurrent proviral integration sites in new models for latent HIV-1 infection. Virus Res. 2018;249:69-75 pubmed 出版商
|
Williams R, Senanayake U, Artibani M, Taylor G, Wells D, Ahmed A, et al. Genome and epigenome engineering CRISPR toolkit for in vivo modulation of cis-regulatory interactions and gene expression in the chicken embryo. Development. 2018;145: pubmed 出版商
|
Chen C, Zeldich E, Li Y, Yuste A, Abraham C. Activation of the Anti-Aging and Cognition-Enhancing Gene Klotho by CRISPR-dCas9 Transcriptional Effector Complex. J Mol Neurosci. 2018;64:175-184 pubmed 出版商
|
Liao H, Hatanaka F, Araoka T, Reddy P, Wu M, Sui Y, et al. In Vivo Target Gene Activation via CRISPR/Cas9-Mediated Trans-epigenetic Modulation. Cell. 2017;171:1495-1507.e15 pubmed 出版商
|
Kulcsár P, Tálas A, Huszár K, Ligeti Z, Tóth E, Weinhardt N, et al. Crossing enhanced and high fidelity SpCas9 nucleases to optimize specificity and cleavage. Genome Biol. 2017;18:190 pubmed 出版商
|
Nihongaki Y, Furuhata Y, Otabe T, Hasegawa S, Yoshimoto K, Sato M. CRISPR-Cas9-based photoactivatable transcription systems to induce neuronal differentiation. Nat Methods. 2017;14:963-966 pubmed 出版商
|
Ferry Q, Lyutova R, Fulga T. Rational design of inducible CRISPR guide RNAs for de novo assembly of transcriptional programs. Nat Commun. 2017;8:14633 pubmed 出版商
|
Hu L, Yu Y, Huang H, Fan H, Hu L, Yin C, et al. Epigenetic Regulation of Interleukin 6 by Histone Acetylation in Macrophages and Its Role in Paraquat-Induced Pulmonary Fibrosis. Front Immunol. 2016;7:696 pubmed 出版商
|
Chen F, Li X, Aquadro E, Haigh S, Zhou J, Stepp D, et al. Inhibition of histone deacetylase reduces transcription of NADPH oxidases and ROS production and ameliorates pulmonary arterial hypertension. Free Radic Biol Med. 2016;99:167-178 pubmed 出版商
|
Bialek J, Dunay G, Voges M, Schäfer C, Spohn M, Stucka R, et al. Targeted HIV-1 Latency Reversal Using CRISPR/Cas9-Derived Transcriptional Activator Systems. PLoS ONE. 2016;11:e0158294 pubmed 出版商
|
Kaczmarczyk L, Mende Y, Zevnik B, Jackson W. Manipulating the Prion Protein Gene Sequence and Expression Levels with CRISPR/Cas9. PLoS ONE. 2016;11:e0154604 pubmed 出版商
|
Konermann S, Brigham M, Trevino A, Joung J, Abudayyeh O, Bárcena C, et al. Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex. Nature. 2015;517:583-8 pubmed 出版商
|