产品简要
公司名称 :
Adipogen
产品类型 :
抗体
产品名称 :
anti-NLRP3/NALP3 mAb (Cryo-2)
目录 :
老化-20B
克隆性 :
单克隆
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片, 免疫印迹基因敲除验证
更多信息或购买 :
文章摘录数: 69
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠; 图 6g
Cheng J, Dong Y, Ma J, Pan R, Liao Y, Kong X, et al. Microglial Calhm2 regulates neuroinflammation and contributes to Alzheimer's disease pathology. Sci Adv. 2021;7: pubmed 出版商
  • 免疫印迹; 小鼠; 图 1f
Ma M, Li G, Qi M, Jiang W, Zhou R. Inhibition of the Inflammasome Activity of NLRP3 Attenuates HDM-Induced Allergic Asthma. Front Immunol. 2021;12:718779 pubmed 出版商
  • 免疫印迹; 小鼠; 图 3c
Zhang Z, Gu X, Zhao X, He X, Shi H, Zhang K, et al. NLRP3 ablation enhances tolerance in heat stroke pathology by inhibiting IL-1β-mediated neuroinflammation. J Neuroinflammation. 2021;18:128 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 2d
Olcum M, Tufekci K, Durur D, Tastan B, Gokbayrak I, Genc K, et al. Ethyl Pyruvate Attenuates Microglial NLRP3 Inflammasome Activation via Inhibition of HMGB1/NF-κB/miR-223 Signaling. Antioxidants (Basel). 2021;10: pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:200; 图 2c
  • 免疫组化-石蜡切片; 大鼠; 1:200; 图 2e
  • 免疫印迹; 大鼠; 1:1000; 图 3c
Chen F, Jiang G, Liu H, Li Z, Pei Y, Wang H, et al. Melatonin alleviates intervertebral disc degeneration by disrupting the IL-1β/NF-κB-NLRP3 inflammasome positive feedback loop. Bone Res. 2020;8:10 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 1a
Gao Y, Tu D, Yang R, Chu C, Hong J, Gao H. Through Reducing ROS Production, IL-10 Suppresses Caspase-1-Dependent IL-1β Maturation, thereby Preventing Chronic Neuroinflammation and Neurodegeneration. Int J Mol Sci. 2020;21: pubmed 出版商
  • 免疫印迹基因敲除验证; 人类; 图 1a
Davis M, Fairgrieve M, den Hartigh A, Yakovenko O, Duvvuri B, Lood C, et al. Calpain drives pyroptotic vimentin cleavage, intermediate filament loss, and cell rupture that mediates immunostimulation. Proc Natl Acad Sci U S A. 2019;116:5061-5070 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1e
Sharma D, Malik A, Guy C, Vogel P, Kanneganti T. TNF/TNFR axis promotes pyrin inflammasome activation and distinctly modulates pyrin inflammasomopathy. J Clin Invest. 2019;129:150-162 pubmed 出版商
  • 免疫印迹; 小鼠; 图 3b
Qu W, Wang Y, Wu Y, Liu Y, Chen K, Liu X, et al. Triggering Receptors Expressed on Myeloid Cells 2 Promotes Corneal Resistance Against Pseudomonas aeruginosa by Inhibiting Caspase-1-Dependent Pyroptosis. Front Immunol. 2018;9:1121 pubmed 出版商
  • 免疫印迹基因敲除验证; 小鼠; 图 1g
Chen Y, Qin X, An Q, Yi J, Feng F, Yin D, et al. Mesenchymal Stromal Cells Directly Promote Inflammation by Canonical NLRP3 and Non-canonical Caspase-11 Inflammasomes. EBioMedicine. 2018;32:31-42 pubmed 出版商
  • 免疫印迹; 小鼠; 图 7e
Czimmerer Z, Dániel B, Horvath A, Rückerl D, Nagy G, Kiss M, et al. The Transcription Factor STAT6 Mediates Direct Repression of Inflammatory Enhancers and Limits Activation of Alternatively Polarized Macrophages. Immunity. 2018;48:75-90.e6 pubmed 出版商
  • 免疫印迹基因敲除验证; 小鼠; 1:1000; 图 5e
  • 免疫沉淀; 小鼠; 图 8b
  • 免疫印迹; 小鼠; 1:1000; 图 5e
Tang T, Lang X, Xu C, Wang X, Gong T, Yang Y, et al. CLICs-dependent chloride efflux is an essential and proximal upstream event for NLRP3 inflammasome activation. Nat Commun. 2017;8:202 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 s1b
Bednash J, Weathington N, Londino J, Rojas M, Gulick D, Fort R, et al. Targeting the deubiquitinase STAMBP inhibits NALP7 inflammasome activity. Nat Commun. 2017;8:15203 pubmed 出版商
  • 免疫印迹基因敲除验证; 人类; 图 s1b
Gutierrez K, Davis M, Daniels B, Olsen T, Ralli Jain P, Tait S, et al. MLKL Activation Triggers NLRP3-Mediated Processing and Release of IL-1β Independently of Gasdermin-D. J Immunol. 2017;198:2156-2164 pubmed 出版商
  • 免疫印迹; 小鼠; 图 3c
Koh H, Kim Y, Kim J, Yun J, Jang K, Yang C. Toxoplasma gondii GRA7-Targeted ASC and PLD1 Promote Antibacterial Host Defense via PKCα. PLoS Pathog. 2017;13:e1006126 pubmed 出版商
  • 免疫印迹基因敲除验证; 小鼠; 图 3b
Wang Y, Yan X, Mi S, Li Z, Wang Y, Zhu H, et al. Naoxintong attenuates Ischaemia/reperfusion Injury through inhibiting NLRP3 inflammasome activation. J Cell Mol Med. 2017;21:4-12 pubmed 出版商
  • 免疫沉淀; 小鼠; 图 4
Du R, Wu F, Lu M, Shu X, Ding J, Wu G, et al. Uncoupling protein 2 modulation of the NLRP3 inflammasome in astrocytes and its implications in depression. Redox Biol. 2016;9:178-187 pubmed 出版商
  • 免疫沉淀; 人类; 1:50; 图 6i
Mortimer L, Moreau F, MacDonald J, Chadee K. NLRP3 inflammasome inhibition is disrupted in a group of auto-inflammatory disease CAPS mutations. Nat Immunol. 2016;17:1176-86 pubmed 出版商
  • 免疫细胞化学; 人类; 1:200; 图 1
  • 免疫印迹; 人类; 1:200; 图 1
De Filippis L, Halikere A, McGowan H, Moore J, Tischfield J, Hart R, et al. Ethanol-mediated activation of the NLRP3 inflammasome in iPS cells and iPS cells-derived neural progenitor cells. Mol Brain. 2016;9:51 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Ezekwe E, Weng C, Duncan J. ADAM10 Cell Surface Expression but Not Activity Is Critical for Staphylococcus aureus ?-Hemolysin-Mediated Activation of the NLRP3 Inflammasome in Human Monocytes. Toxins (Basel). 2016;8:95 pubmed 出版商
  • 免疫印迹基因敲除验证; 小鼠; 图 s7
de Torre Minguela C, Barberà Cremades M, Gómez A, Martín Sánchez F, Pelegrín P. Macrophage activation and polarization modify P2X7 receptor secretome influencing the inflammatory process. Sci Rep. 2016;6:22586 pubmed 出版商
  • 免疫印迹; 小鼠; 1:100; 图 5e
Martín Sánchez F, Diamond C, Zeitler M, Gómez A, Baroja Mazo A, Bagnall J, et al. Inflammasome-dependent IL-1β release depends upon membrane permeabilisation. Cell Death Differ. 2016;23:1219-31 pubmed 出版商
  • 免疫印迹; 人类; 图 5c
  • 免疫印迹; 小鼠; 图 3a
Haque S, Lan X, Wen H, Lederman R, Chawla A, Attia M, et al. HIV Promotes NLRP3 Inflammasome Complex Activation in Murine HIV-Associated Nephropathy. Am J Pathol. 2016;186:347-58 pubmed 出版商
  • 免疫印迹; 人类; 图 1c
Viganò E, Diamond C, Spreafico R, Balachander A, Sobota R, Mortellaro A. Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes. Nat Commun. 2015;6:8761 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000; 图 5a
Mocanu A, Mulya A, Huang H, Dan O, Shimizu H, Batayyah E, et al. Effect of Roux-en-Y Gastric Bypass on the NLRP3 Inflammasome in Adipose Tissue from Obese Rats. PLoS ONE. 2015;10:e0139764 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:100
Bruchard M, Rebé C, Derangère V, Togbé D, Ryffel B, Boidot R, et al. The receptor NLRP3 is a transcriptional regulator of TH2 differentiation. Nat Immunol. 2015;16:859-70 pubmed 出版商
  • 免疫组化-石蜡切片; 大鼠; 1:200
Kono S, Kurata T, Sato K, Omote Y, Hishikawa N, Yamashita T, et al. Neurovascular protection by telmisartan via reducing neuroinflammation in stroke-resistant spontaneously hypertensive rat brain after ischemic stroke. J Stroke Cerebrovasc Dis. 2015;24:537-47 pubmed 出版商
  • 免疫印迹; 大鼠; 1:500
Ortiz F, Acuña Castroviejo D, Doerrier C, Dayoub J, López L, Venegas C, et al. Melatonin blunts the mitochondrial/NLRP3 connection and protects against radiation-induced oral mucositis. J Pineal Res. 2015;58:34-49 pubmed 出版商
  • 免疫印迹; 人类
Derangère V, Chevriaux A, Courtaut F, Bruchard M, Berger H, Chalmin F, et al. Liver X receptor ? activation induces pyroptosis of human and murine colon cancer cells. Cell Death Differ. 2014;21:1914-24 pubmed 出版商
Zhang S, Yuan B, Lam J, Zhou J, Zhou X, Ramos Mandujano G, et al. Structure of the full-length human Pannexin1 channel and insights into its role in pyroptosis. Cell Discov. 2021;7:30 pubmed 出版商
Farré Alins V, Narros Fernández P, Palomino Antolin A, Decouty Pérez C, López Rodríguez A, Parada E, et al. Melatonin Reduces NLRP3 Inflammasome Activation by Increasing α7 nAChR-Mediated Autophagic Flux. Antioxidants (Basel). 2020;9: pubmed 出版商
Zhang X, Wang R, Hu D, Sun X, Fujioka H, Lundberg K, et al. Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer's disease. Sci Adv. 2020;6: pubmed 出版商
Wang W, Hu D, Feng Y, Wu C, Song Y, Liu W, et al. Paxillin mediates ATP-induced activation of P2X7 receptor and NLRP3 inflammasome. BMC Biol. 2020;18:182 pubmed 出版商
Guo Y, Gu D, Huang T, Cao L, Zhu X, Zhou Y, et al. Essential role of Salmonella Enteritidis DNA adenine methylase in modulating inflammasome activation. BMC Microbiol. 2020;20:226 pubmed 出版商
Zhu M, Du L, Zhao R, Wang H, Zhao Y, Nie G, et al. Cell-Penetrating Nanoparticles Activate the Inflammasome to Enhance Antibody Production by Targeting Microtubule-Associated Protein 1-Light Chain 3 for Degradation. ACS Nano. 2020;14:3703-3717 pubmed 出版商
Samir P, Kesavardhana S, Patmore D, Gingras S, Malireddi R, Karki R, et al. DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome. Nature. 2019;573:590-594 pubmed 出版商
Du R, Lu M, Wang C, Ding J, Wu G, Hu G. The pore-forming subunit Kir6.1 of the K-ATP channel negatively regulates the NLRP3 inflammasome to control insulin resistance by interacting with NLRP3. Exp Mol Med. 2019;51:92 pubmed 出版商
Huang X, Feng Z, Jiang Y, Li J, Xiang Q, Guo S, et al. VSIG4 mediates transcriptional inhibition of Nlrp3 and Il-1β in macrophages. Sci Adv. 2019;5:eaau7426 pubmed 出版商
Mehto S, Jena K, Nath P, Chauhan S, Kolapalli S, Das S, et al. The Crohn's Disease Risk Factor IRGM Limits NLRP3 Inflammasome Activation by Impeding Its Assembly and by Mediating Its Selective Autophagy. Mol Cell. 2019;73:429-445.e7 pubmed 出版商
Kiyohara H, Sujino T, Teratani T, Miyamoto K, Arai M, Nomura E, et al. Toll-Like Receptor 7 Agonist-Induced Dermatitis Causes Severe Dextran Sulfate Sodium Colitis by Altering the Gut Microbiome and Immune Cells. Cell Mol Gastroenterol Hepatol. 2019;7:135-156 pubmed 出版商
Hafner Bratkovic I, Sušjan P, Lainšček D, Tapia Abellán A, Cerović K, Kadunc L, et al. NLRP3 lacking the leucine-rich repeat domain can be fully activated via the canonical inflammasome pathway. Nat Commun. 2018;9:5182 pubmed 出版商
Tyagi A, Nguyen C, Chong T, Michel C, Fritz K, Reisdorph N, et al. SIRT3 deficiency-induced mitochondrial dysfunction and inflammasome formation in the brain. Sci Rep. 2018;8:17547 pubmed 出版商
Xu C, Lu Z, Luo Y, Liu Y, Cao Z, Shen S, et al. Targeting of NLRP3 inflammasome with gene editing for the amelioration of inflammatory diseases. Nat Commun. 2018;9:4092 pubmed 出版商
Zhang Y, Rong H, Zhang F, Wu K, Mu L, Meng J, et al. A Membrane Potential- and Calpain-Dependent Reversal of Caspase-1 Inhibition Regulates Canonical NLRP3 Inflammasome. Cell Rep. 2018;24:2356-2369.e5 pubmed 出版商
Barry R, John S, Liccardi G, Tenev T, Jaco I, Chen C, et al. SUMO-mediated regulation of NLRP3 modulates inflammasome activity. Nat Commun. 2018;9:3001 pubmed 出版商
de la Roche M, Hamilton C, Mortensen R, Jeyaprakash A, Ghosh S, Anand P. Trafficking of cholesterol to the ER is required for NLRP3 inflammasome activation. J Cell Biol. 2018;217:3560-3576 pubmed 出版商
Zhong Z, Liang S, Sanchez Lopez E, He F, Shalapour S, Lin X, et al. New mitochondrial DNA synthesis enables NLRP3 inflammasome activation. Nature. 2018;560:198-203 pubmed 出版商
Mouton Liger F, Rosazza T, Sepulveda Diaz J, Ieang A, Hassoun S, Claire E, et al. Parkin deficiency modulates NLRP3 inflammasome activation by attenuating an A20-dependent negative feedback loop. Glia. 2018;: pubmed 出版商
Tang T, Lv L, Pan M, Wen Y, Wang B, Li Z, et al. Hydroxychloroquine attenuates renal ischemia/reperfusion injury by inhibiting cathepsin mediated NLRP3 inflammasome activation. Cell Death Dis. 2018;9:351 pubmed 出版商
Malireddi R, Gurung P, Mavuluri J, Dasari T, Klco J, Chi H, et al. TAK1 restricts spontaneous NLRP3 activation and cell death to control myeloid proliferation. J Exp Med. 2018;215:1023-1034 pubmed 出版商
Liu J, Mustafa S, Barratt D, Hutchinson M. Corticosterone Preexposure Increases NF-κB Translocation and Sensitizes IL-1β Responses in BV2 Microglia-Like Cells. Front Immunol. 2018;9:3 pubmed 出版商
Clift D, McEwan W, Labzin L, Konieczny V, Mogessie B, James L, et al. A Method for the Acute and Rapid Degradation of Endogenous Proteins. Cell. 2017;171:1692-1706.e18 pubmed 出版商
Swanson K, Junkins R, Kurkjian C, Holley Guthrie E, Pendse A, El Morabiti R, et al. A noncanonical function of cGAMP in inflammasome priming and activation. J Exp Med. 2017;214:3611-3626 pubmed 出版商
Jiang H, He H, Chen Y, Huang W, Cheng J, Ye J, et al. Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders. J Exp Med. 2017;214:3219-3238 pubmed 出版商
Song N, Liu Z, Xue W, Bai Z, Wang Q, Dai J, et al. NLRP3 Phosphorylation Is an Essential Priming Event for Inflammasome Activation. Mol Cell. 2017;68:185-197.e6 pubmed 出版商
Khalafalla M, Woods L, Camden J, Khan A, Limesand K, Petris M, et al. P2X7 receptor antagonism prevents IL-1? release from salivary epithelial cells and reduces inflammation in a mouse model of autoimmune exocrinopathy. J Biol Chem. 2017;292:16626-16637 pubmed 出版商
Traba J, Geiger S, Kwarteng Siaw M, Han K, Ra O, Siegel R, et al. Prolonged fasting suppresses mitochondrial NLRP3 inflammasome assembly and activation via SIRT3-mediated activation of superoxide dismutase 2. J Biol Chem. 2017;292:12153-12164 pubmed 出版商
Cannito S, Morello E, Bocca C, Foglia B, Benetti E, Novo E, et al. Microvesicles released from fat-laden cells promote activation of hepatocellular NLRP3 inflammasome: A pro-inflammatory link between lipotoxicity and non-alcoholic steatohepatitis. PLoS ONE. 2017;12:e0172575 pubmed 出版商
Conos S, Chen K, De Nardo D, Hara H, Whitehead L, Núñez G, et al. Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner. Proc Natl Acad Sci U S A. 2017;114:E961-E969 pubmed 出版商
Wei C, Wang Y, Du Z, Guan K, Cao Y, Yang H, et al. The Yersinia Type III secretion effector YopM Is an E3 ubiquitin ligase that induced necrotic cell death by targeting NLRP3. Cell Death Dis. 2016;7:e2519 pubmed 出版商
Zhang Z, Du X, Ma X, Zong Y, Chen J, Yu C, et al. Activation of the NLRP3 inflammasome in lipopolysaccharide-induced mouse fatigue and its relevance to chronic fatigue syndrome. J Neuroinflammation. 2016;13:71 pubmed 出版商
Zhao J, Mou Y, Bernstock J, Klimanis D, Wang S, Spatz M, et al. Synthetic Oligodeoxynucleotides Containing Multiple Telemeric TTAGGG Motifs Suppress Inflammasome Activity in Macrophages Subjected to Oxygen and Glucose Deprivation and Reduce Ischemic Brain Injury in Stroke-Prone Spontaneously Hypertensive Rats. PLoS ONE. 2015;10:e0140772 pubmed 出版商
Gurung P, Li B, Subbarao Malireddi R, Lamkanfi M, Geiger T, Kanneganti T. Chronic TLR Stimulation Controls NLRP3 Inflammasome Activation through IL-10 Mediated Regulation of NLRP3 Expression and Caspase-8 Activation. Sci Rep. 2015;5:14488 pubmed 出版商
Mortimer L, Moreau F, Cornick S, Chadee K. The NLRP3 Inflammasome Is a Pathogen Sensor for Invasive Entamoeba histolytica via Activation of α5β1 Integrin at the Macrophage-Amebae Intercellular Junction. PLoS Pathog. 2015;11:e1004887 pubmed 出版商
Dos Santos G, Rogel M, Baker M, Troken J, Urich D, Morales Nebreda L, et al. Vimentin regulates activation of the NLRP3 inflammasome. Nat Commun. 2015;6:6574 pubmed 出版商
Yang C, Kim J, Kim T, Lee P, Kim S, Lee H, et al. Small heterodimer partner interacts with NLRP3 and negatively regulates activation of the NLRP3 inflammasome. Nat Commun. 2015;6:6115 pubmed 出版商
Yoshida K, Yoshioka M, Okamura H, Moriyama S, Kawazoe K, Grenier D, et al. Preventive effect of Daiokanzoto (TJ-84) on 5-fluorouracil-induced human gingival cell death through the inhibition of reactive oxygen species production. PLoS ONE. 2014;9:e112689 pubmed 出版商
Vande Walle L, Van Opdenbosch N, Jacques P, Fossoul A, Verheugen E, Vogel P, et al. Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis. Nature. 2014;512:69-73 pubmed 出版商
Park Y, Yoon S, Suh H, Kim D, Park J, Jung H, et al. TXNIP deficiency exacerbates endotoxic shock via the induction of excessive nitric oxide synthesis. PLoS Pathog. 2013;9:e1003646 pubmed 出版商
公司信息
Adipogen
info@adipogen.com
http://www.adipogen.com