产品简要
公司名称 :
Adipogen
产品类型 :
抗体
产品名称 :
anti-Caspase-1 (p20) (mouse) mAb (Casper-1)
目录 :
老化-20B
克隆性 :
单克隆
共轭标签 :
未共轭
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫印迹基因敲除验证
更多信息或购买 :
文章摘录数: 54
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠; 1:50; 图 s10g
Ising C, Venegas C, Zhang S, Scheiblich H, Schmidt S, Vieira Saecker A, et al. NLRP3 inflammasome activation drives tau pathology. Nature. 2019;: pubmed 出版商
  • 免疫印迹; 小鼠; 1:100; 图 1b
Samir P, Kesavardhana S, Patmore D, Gingras S, Malireddi R, Karki R, et al. DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome. Nature. 2019;573:590-594 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1e
Huang X, Feng Z, Jiang Y, Li J, Xiang Q, Guo S, et al. VSIG4 mediates transcriptional inhibition of Nlrp3 and Il-1β in macrophages. Sci Adv. 2019;5:eaau7426 pubmed 出版商
  • 免疫印迹; 小鼠; 图 2a
  • 免疫印迹; 人类; 图 2j
Zhang C, Jiang M, Zhou H, Liu W, Wang C, Kang Z, et al. TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation. J Clin Invest. 2018;128:5399-5412 pubmed 出版商
  • 免疫印迹; 小鼠; 图 2h
Li F, Li Y, Liang H, Xu T, Kong Y, Huang M, et al. HECTD3 mediates TRAF3 polyubiquitination and type I interferon induction during bacterial infection. J Clin Invest. 2018;128:4148-4162 pubmed 出版商
  • 免疫印迹; 小鼠; 图 3b
Qu W, Wang Y, Wu Y, Liu Y, Chen K, Liu X, et al. Triggering Receptors Expressed on Myeloid Cells 2 Promotes Corneal Resistance Against Pseudomonas aeruginosa by Inhibiting Caspase-1-Dependent Pyroptosis. Front Immunol. 2018;9:1121 pubmed 出版商
  • 免疫印迹基因敲除验证; 小鼠; 图 2a
  • 免疫印迹; 小鼠; 图 1g
Chen Y, Qin X, An Q, Yi J, Feng F, Yin D, et al. Mesenchymal Stromal Cells Directly Promote Inflammation by Canonical NLRP3 and Non-canonical Caspase-11 Inflammasomes. EBioMedicine. 2018;32:31-42 pubmed 出版商
  • 免疫印迹; 小鼠; 图 2a
Malireddi R, Gurung P, Mavuluri J, Dasari T, Klco J, Chi H, et al. TAK1 restricts spontaneous NLRP3 activation and cell death to control myeloid proliferation. J Exp Med. 2018;215:1023-1034 pubmed 出版商
  • 免疫印迹; 小鼠; 图 7e
Czimmerer Z, Dániel B, Horvath A, Rückerl D, Nagy G, Kiss M, et al. The Transcription Factor STAT6 Mediates Direct Repression of Inflammatory Enhancers and Limits Activation of Alternatively Polarized Macrophages. Immunity. 2018;48:75-90.e6 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 1f
  • 免疫印迹; 小鼠; 1:1000; 图 1a
Tang T, Lang X, Xu C, Wang X, Gong T, Yang Y, et al. CLICs-dependent chloride efflux is an essential and proximal upstream event for NLRP3 inflammasome activation. Nat Commun. 2017;8:202 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4g
Domingo Fernández R, Coll R, Kearney J, Breit S, O Neill L. The intracellular chloride channel proteins CLIC1 and CLIC4 induce IL-1? transcription and activate the NLRP3 inflammasome. J Biol Chem. 2017;292:12077-12087 pubmed 出版商
  • 免疫印迹; 小鼠; 图 2b
Leal Lasarte M, Franco J, Labrador Garrido A, Pozo D, Roodveldt C. Extracellular TDP-43 aggregates target MAPK/MAK/MRK overlapping kinase (MOK) and trigger caspase-3/IL-18 signaling in microglia. FASEB J. 2017;31:2797-2816 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 2b
Thurston T, Matthews S, Jennings E, Alix E, Shao F, Shenoy A, et al. Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death. Nat Commun. 2016;7:13292 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 2
Wang X, Shaw D, Hammond H, Sutterwala F, Rayamajhi M, Shirey K, et al. The Prostaglandin E2-EP3 Receptor Axis Regulates Anaplasma phagocytophilum-Mediated NLRC4 Inflammasome Activation. PLoS Pathog. 2016;12:e1005803 pubmed 出版商
  • 免疫印迹; 小鼠; 1 ug/ml; 图 5A
Russo H, Rathkey J, Boyd Tressler A, Katsnelson M, Abbott D, Dubyak G. Active Caspase-1 Induces Plasma Membrane Pores That Precede Pyroptotic Lysis and Are Blocked by Lanthanides. J Immunol. 2016;197:1353-67 pubmed 出版商
  • 免疫印迹; 小鼠; 1:4000; 图 6
Dick M, Sborgi L, Rühl S, Hiller S, Broz P. ASC filament formation serves as a signal amplification mechanism for inflammasomes. Nat Commun. 2016;7:11929 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 6
Wang X, Shaw D, Sakhon O, Snyder G, Sundberg E, Santambrogio L, et al. The Tick Protein Sialostatin L2 Binds to Annexin A2 and Inhibits NLRC4-Mediated Inflammasome Activation. Infect Immun. 2016;84:1796-1805 pubmed 出版商
  • 免疫印迹; 小鼠; 图 3
Ravindran R, Loebbermann J, Nakaya H, Khan N, Ma H, Gama L, et al. The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation. Nature. 2016;531:523-527 pubmed 出版商
  • 免疫印迹基因敲除验证; 小鼠; 1 ug/ml; 图 1f
Antonopoulos C, Russo H, El Sanadi C, Martin B, Li X, Kaiser W, et al. Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling. J Biol Chem. 2015;290:20167-84 pubmed 出版商
Chen F, Jiang G, Liu H, Li Z, Pei Y, Wang H, et al. Melatonin alleviates intervertebral disc degeneration by disrupting the IL-1β/NF-κB-NLRP3 inflammasome positive feedback loop. Bone Res. 2020;8:10 pubmed 出版商
Guo H, Liu H, Jian Z, Cui H, Fang J, Zuo Z, et al. Nickel induces inflammatory activation via NF-κB, MAPKs, IRF3 and NLRP3 inflammasome signaling pathways in macrophages. Aging (Albany NY). 2019;11:11659-11672 pubmed 出版商
Hughes M, Hooftman A, Angiari S, Tummala P, Zaslona Z, Runtsch M, et al. Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation. Cell Rep. 2019;29:151-161.e5 pubmed 出版商
Vande Walle L, Stowe I, Sácha P, Lee B, Demon D, Fossoul A, et al. MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition. PLoS Biol. 2019;17:e3000354 pubmed 出版商
Hornick E, Dagvadorj J, Zacharias Z, Miller A, Langlois R, Chen P, et al. Dendritic cell NLRC4 regulates influenza A virus-specific CD4 T cell responses through FasL expression. J Clin Invest. 2019;129:2888-2897 pubmed 出版商
Sandstrom A, Mitchell P, Goers L, Mu E, Lesser C, Vance R. Functional degradation: A mechanism of NLRP1 inflammasome activation by diverse pathogen enzymes. Science. 2019;364: pubmed 出版商
Briard B, Karki R, Malireddi R, Bhattacharya A, Place D, Mavuluri J, et al. Fungal ligands released by innate immune effectors promote inflammasome activation during Aspergillus fumigatus infection. Nat Microbiol. 2019;4:316-327 pubmed 出版商
Sharma D, Malik A, Guy C, Vogel P, Kanneganti T. TNF/TNFR axis promotes pyrin inflammasome activation and distinctly modulates pyrin inflammasomopathy. J Clin Invest. 2019;129:150-162 pubmed 出版商
Mouhadeb O, Ben Shlomo S, Cohen K, Farkash I, Gruber S, Maharshak N, et al. Impaired COMMD10-Mediated Regulation of Ly6Chi Monocyte-Driven Inflammation Disrupts Gut Barrier Function. Front Immunol. 2018;9:2623 pubmed 出版商
Kasper L, König A, Koenig P, Gresnigt M, Westman J, Drummond R, et al. The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes. Nat Commun. 2018;9:4260 pubmed 出版商
Chen H, Fang Y, Wu J, Chen H, Zou Z, Zhang X, et al. RIPK3-MLKL-mediated necroinflammation contributes to AKI progression to CKD. Cell Death Dis. 2018;9:878 pubmed 出版商
Zhang Y, Rong H, Zhang F, Wu K, Mu L, Meng J, et al. A Membrane Potential- and Calpain-Dependent Reversal of Caspase-1 Inhibition Regulates Canonical NLRP3 Inflammasome. Cell Rep. 2018;24:2356-2369.e5 pubmed 出版商
de la Roche M, Hamilton C, Mortensen R, Jeyaprakash A, Ghosh S, Anand P. Trafficking of cholesterol to the ER is required for NLRP3 inflammasome activation. J Cell Biol. 2018;217:3560-3576 pubmed 出版商
Zhong Z, Liang S, Sanchez Lopez E, He F, Shalapour S, Lin X, et al. New mitochondrial DNA synthesis enables NLRP3 inflammasome activation. Nature. 2018;560:198-203 pubmed 出版商
Lang T, Lee J, Elgass K, Pinar A, Tate M, Aitken E, et al. Macrophage migration inhibitory factor is required for NLRP3 inflammasome activation. Nat Commun. 2018;9:2223 pubmed 出版商
Kanneganti A, Malireddi R, Saavedra P, Vande Walle L, Van Gorp H, Kambara H, et al. GSDMD is critical for autoinflammatory pathology in a mouse model of Familial Mediterranean Fever. J Exp Med. 2018;215:1519-1529 pubmed 出版商
Karki R, Lee E, Place D, Samir P, Mavuluri J, Sharma B, et al. IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation. Cell. 2018;173:920-933.e13 pubmed 出版商
Place D, Samir P, Karki R, Briard B, Vogel P, Kanneganti T. ASK Family Kinases Are Required for Optimal NLRP3 Inflammasome Priming. Am J Pathol. 2018;188:1021-1030 pubmed 出版商
Kuriakose T, Zheng M, Neale G, Kanneganti T. IRF1 Is a Transcriptional Regulator of ZBP1 Promoting NLRP3 Inflammasome Activation and Cell Death during Influenza Virus Infection. J Immunol. 2018;200:1489-1495 pubmed 出版商
Costa Franco M, Marim F, Guimarães E, Assis N, Cerqueira D, Alves Silva J, et al. Brucella abortus Triggers a cGAS-Independent STING Pathway To Induce Host Protection That Involves Guanylate-Binding Proteins and Inflammasome Activation. J Immunol. 2018;200:607-622 pubmed 出版商
He Y, She H, Zhang T, Xu H, Cheng L, Yepes M, et al. p38 MAPK inhibits autophagy and promotes microglial inflammatory responses by phosphorylating ULK1. J Cell Biol. 2018;217:315-328 pubmed 出版商
Wang W, Shi Q, Dou S, Li G, Shi X, Jiang X, et al. Negative regulation of Nod-like receptor protein 3 inflammasome activation by T cell Ig mucin-3 protects against peritonitis. Immunology. 2018;153:71-83 pubmed 出版商
Van Opdenbosch N, Van Gorp H, Verdonckt M, Saavedra P, de Vasconcelos N, Gonçalves A, et al. Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC4. Cell Rep. 2017;21:3427-3444 pubmed 出版商
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Jiang H, He H, Chen Y, Huang W, Cheng J, Ye J, et al. Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders. J Exp Med. 2017;214:3219-3238 pubmed 出版商
Cheng K, Xiong S, Ye Z, Hong Z, Di A, Tsang K, et al. Caspase-11-mediated endothelial pyroptosis underlies endotoxemia-induced lung injury. J Clin Invest. 2017;127:4124-4135 pubmed 出版商
Song N, Liu Z, Xue W, Bai Z, Wang Q, Dai J, et al. NLRP3 Phosphorylation Is an Essential Priming Event for Inflammasome Activation. Mol Cell. 2017;68:185-197.e6 pubmed 出版商
Ghosh S, Wallerath C, Covarrubias S, Hornung V, Carpenter S, Fitzgerald K. The PYHIN Protein p205 Regulates the Inflammasome by Controlling Asc Expression. J Immunol. 2017;199:3249-3260 pubmed 出版商
Yoon S, Kovalenko A, Bogdanov K, Wallach D. MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation. Immunity. 2017;47:51-65.e7 pubmed 出版商
Traba J, Geiger S, Kwarteng Siaw M, Han K, Ra O, Siegel R, et al. Prolonged fasting suppresses mitochondrial NLRP3 inflammasome assembly and activation via SIRT3-mediated activation of superoxide dismutase 2. J Biol Chem. 2017;292:12153-12164 pubmed 出版商
Yang A, Inamine T, Hochrath K, Chen P, Wang L, Llorente C, et al. Intestinal fungi contribute to development of alcoholic liver disease. J Clin Invest. 2017;127:2829-2841 pubmed 出版商
Conos S, Chen K, De Nardo D, Hara H, Whitehead L, Núñez G, et al. Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner. Proc Natl Acad Sci U S A. 2017;114:E961-E969 pubmed 出版商
Kuchmiy A, D Hont J, Hochepied T, Lamkanfi M. NLRP2 controls age-associated maternal fertility. J Exp Med. 2016;213:2851-2860 pubmed
Qi X, Man S, Malireddi R, Karki R, Lupfer C, Gurung P, et al. Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection. J Exp Med. 2016;213:2081-97 pubmed 出版商
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公司信息
Adipogen
info@adipogen.com
http://www.adipogen.com