产品简要
公司名称 :
Agrisera
产品类型 :
抗体
产品名称 :
纤维蛋白原, 标记物是荧光素
目录 :
IMS09-038-335
规格 :
100微升(0.2毫克/毫升)
价格 :
348美元
克隆性 :
多克隆
宿主 :
鸡
共轭标签 :
未共轭
应用 :
流式细胞仪
更多信息或购买 :
产品信息
产品号 :
IMS09-038-335
产品名称 :
纤维蛋白原, 标记物是荧光素
规格 :
100微升(0.2毫克/毫升)
标价 :
348美元
免疫原 :
纯化, 全长天然纤维蛋白原UniProt:Q9UE34
宿主 :
鸡
克隆性 :
多克隆
纯度 :
免疫原亲和纯化IgY在0.15M氯化钠, 0.02M钠磷酸盐, 0.1% 叠氮化钠., pH值7.2
格式 :
液体
检测过的应用 :
Flow cytometry (Flow cyt)
推荐的稀释浓度 :
1: 10(FC)
预计表观分子量 :
24 kDa
确认的物种反应活性 :
人类, 猪, 大鼠, 兔
前体活性 :
牛, 小鼠
不反应 :
No confirmed exceptions from predicted reactivity are currently known.
其他信息 :
The antibodies have been shown to react with activated human, porcine, rat and rabbit platelets
选取的参考文献 :
Terada et al. (2014). Effects of riboflavin and ultraviolet light treatment on platelet thrombus formation on collagen via integrin αIIb β3 activation. Transfusion. 2014 Feb 8. doi: 10.1111/trf.12566.Schmidt et al. (2012). Phenotyping of Staphylococcus aureus reveals a new virulent ST398 lineage. Clin. Microb. and Infection.
背景 :
Fibrinogen is the main protein of blood coagulation system. It is a large protein and it consists of two identical subunits that contain three polypeptide chains: alpha, beta and gamma. All chains are connected with each other by a number of disulfide bonds. Fibrinopeptides A (1 to 16 amino acids) and B (1 to 17 amino acids) are released by thrombin from the N-terminal parts of alpha and beta chains, respectively. In this way fibrinogen is converted into fibrin, which by means of polymerization forms a fibrin clot. Fibrinogen clotting underlies pathogenesis of MI, thromboembolism and thromboses of arteries and veins, since fibrin is the main substrate for thrombus formation. Fibrinogen activation is also involved in pathogenesis of inflammation, tumor growth and many other diseases. The normal fibrinogen concentration in plasma is about 3 mg/ml. The elevated level of fibrinogen in patient's blood is regarded as an independent risk factor for cardiovascular diseases. An increase in blood fibrinogen concentration was shown to be a strong predictor of coronary heart disease (Sonel et al. 2000; Rapold et al. 1989).
储存 :
Store at 4°C; make aliquots to avoid working with a stock. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.
其他信息 :
The IgY fraction is isolated by a two-step PEG precipitation procedure followed by ammonium sulphate precipitation, Labelled with fluorescein, Affinity purified on human fibrinogen agarose
UniProt数据库数目 :
Q9UE34
Commodity Code :
38220000
Our Category :
Cardiovascular
研究领域 :
蛋白质组学
更多信息或购买 :
公司信息
Agrisera
Agrisera是一家专业生产多克隆和单克隆抗体瑞典公司。高质量的服务水平和确实有效的抗体。30年来在与世界各地的制药公司和研究团体密切合作。