四氨基吡啶 | Alomone Labs A-115 产品信息

产品简要

公司名称 :

Alomone Labs

产品类型 :

化学品

产品名称 :

四氨基吡啶

A-115

规格 :

25 g

更多信息或购买 :

Alomone Labs 产品网页

文章摘录数: 12

参考文献
Manoukian O, Rudraiah S, Arul M, Bartley J, Baker J, Yu X, et al. Biopolymer-nanotube nerve guidance conduit drug delivery for peripheral nerve regeneration: In vivo structural and functional assessment. Bioact Mater. 2021;6:2881-2893 pubmed 出版商
Tyagi S, Bendrick T, Filipova D, Papadopoulos S, Bannister R. A mutation in CaV2.1 linked to a severe neurodevelopmental disorder impairs channel gating. J Gen Physiol. 2019;151:850-859 pubmed 出版商
Manoukian O, Arul M, Rudraiah S, Kalajzic I, Kumbar S. Aligned microchannel polymer-nanotube composites for peripheral nerve regeneration: Small molecule drug delivery. J Control Release. 2019;296:54-67 pubmed 出版商
Abs E, Poorthuis R, Apelblat D, Muhammad K, Pardi M, Enke L, et al. Learning-Related Plasticity in Dendrite-Targeting Layer 1 Interneurons. Neuron. 2018;100:684-699.e6 pubmed 出版商
Lim L, Pakan J, Selten M, Marques Smith A, Llorca A, Bae S, et al. Optimization of interneuron function by direct coupling of cell migration and axonal targeting. Nat Neurosci. 2018;21:920-931 pubmed 出版商
Madry C, Kyrargyri V, Arancibia Carcamo I, Jolivet R, Kohsaka S, Bryan R, et al. Microglial Ramification, Surveillance, and Interleukin-1? Release Are Regulated by the Two-Pore Domain K+ Channel THIK-1. Neuron. 2018;97:299-312.e6 pubmed 出版商
Melonakos E, White J, Fernandez F. Gain Modulation of Cholinergic Neurons in the Medial Septum-Diagonal Band of Broca Through Hyperpolarization. Hippocampus. 2016;26:1525-1541 pubmed 出版商
Gimenez Cassina A, Martínez François J, Fisher J, Szlyk B, Polak K, Wiwczar J, et al. BAD-dependent regulation of fuel metabolism and K(ATP) channel activity confers resistance to epileptic seizures. Neuron. 2012;74:719-30 pubmed 出版商
Tegla C, Cudrici C, Rozycka M, Soloviova K, Ito T, Singh A, et al. C5b-9-activated, K(v)1.3 channels mediate oligodendrocyte cell cycle activation and dedifferentiation. Exp Mol Pathol. 2011;91:335-45 pubmed 出版商
Large R, Hollywood M, Sergeant G, Thornbury K, Bourke S, Levick J, et al. Ionic currents in intimal cultured synoviocytes from the rabbit. Am J Physiol Cell Physiol. 2010;299:C1180-94 pubmed 出版商
Norris A, Nerbonne J. Molecular dissection of I(A) in cortical pyramidal neurons reveals three distinct components encoded by Kv4.2, Kv4.3, and Kv1.4 alpha-subunits. J Neurosci. 2010;30:5092-101 pubmed 出版商
Greenhill S, Jones R. Diverse antiepileptic drugs increase the ratio of background synaptic inhibition to excitation and decrease neuronal excitability in neurones of the rat entorhinal cortex in vitro. Neuroscience. 2010;167:456-74 pubmed 出版商

图像

图像 1 :

Peptide KDYPASTSQDSFEA(C) corresponding to amino acid residues 263-276 of human KV1.3 (Accession P22001). 1st extracellular loop.

产品信息

产品种类 :

Small Molecule

产品名称 :

四氨基吡啶

产品描述 :

4-Aminopyridine is a non-selective Kv channel blocker, which blocks nearly all Kv currents although its potency varies over a wide range. It blocks Kv 2.1 and Kv 3.1 channels with IC50 of 18 and 0.1 mM, respectively, in oocytes. Kv 1.1 and Kv 1.2 channels are blocked by 4-AP with IC50 of 147 muM and 230 muM, respectively, in CHO cells. It has also been used in the clinic to manage some of the symptoms of Multiple Sclerosis.

Package Content :

Reagent vial, SDS documentation

品牌名 :

Alomone Labs

ManufacturerCatalogID :

A-115

SupplierCatalogID :

A-115

包装规格 :

1

产品规格/规格 :

25 g

单位 :

g

Minimum Order Quantity :

1

船国家[美国] :

以色列

Default Carrier [US] :

Fedex

Order Processing Time [US] :

1

Est. Transit Time [US] :

3

船国家[GB] :

以色列

Default Carrier [GB] :

Fedex

Order Processing Time [GB] :

1

Est. Transit Time [GB] :

3

船国家[EU] :

以色列

Default Carrier [EU] :

Fedex

Order Processing Time [EU] :

1

Est. Transit Time [EU] :

3

美国HS编码 :

2933.39.9200

EU HS编码 :

2933399990

船细节 :

Ship at room temperature, temperature stabilized product

别称 :

4-AP

CAS# :

504-24-5

靶标 :

Kv K+ channels

活性 :

4-Aminopyridine is a non-selective Kv channel blocker, which blocks nearly all Kv currents although its potency varies over a wide range. It blocks Kv 2.1 and Kv 3.1 channels with IC50 of 18 and 0.1 mM, respectively, in oocytes. Kv 1.1 and Kv 1.2 channels are blocked by 4-AP with IC50 of 147 muM and 230 muM, respectively, in CHO cells. It has also been used in the clinic to manage some of the symptoms of Multiple Sclerosis.

类型 :

Antagonists & Inhibitors

分子名称 :

四氨基吡啶

基因/蛋白号码 :

KCNA1, KCNA2, KCNA3, KCNA4, KCNA5, KCNA6, KCNA7, KCNA8, KCNB1, KCNC1, KCNC4, KCNC2

来源 :

Synthetic

配方 :

C5H6N2

分子量 :

94.1

格式 :

Lyophilized/solid.

纯度 :

>99% (HPLC)

主要种类 :

Ion Channels > K+ Channels > Voltage-Gated K+ Channels > Blockers

更多信息或购买 :

Alomone Labs 产品网页

公司信息

Alomone Labs

Jerusalem BioPark (JBP), Hadassah Ein Kerem
P.O. Box 4287
Jerusalem 9104201

info@alomone.com

http://www.alomone.com

972-2-587-2202

公司总部: 以色列

Alomone Labs公司成立于1989年，在离子通道、GPCR及神经信号通路研究等领域占据全球领先地位。