产品简要
公司名称 :
Alomone Labs
产品类型 :
抗体
产品名称 :
抗Cav1.2(CACNA1C)抗体
目录 :
ACC-003
规格 :
1 X 25 mcl
价格 :
425美元
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
豚鼠, 人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 101
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠; 1:200; 图 2d
Dai W, Laforest B, Tyan L, Shen K, Nadadur R, Alvarado F, et al. A calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice. elife. 2019;8: pubmed 出版商
  • 免疫印迹; 小鼠; 图 2b
Hu J, Gao C, Wei C, Xue Y, Shao C, Hao Y, et al. RBFox2-miR-34a-Jph2 axis contributes to cardiac decompensation during heart failure. Proc Natl Acad Sci U S A. 2019;116:6172-6180 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1b
Guo A, Wang Y, Chen B, Wang Y, Yuan J, Zhang L, et al. E-C coupling structural protein junctophilin-2 encodes a stress-adaptive transcription regulator. Science. 2018;362: pubmed 出版商
  • 免疫细胞化学; 人类; 1:100; 图 4a
  • 免疫印迹; 人类; 1:1000; 图 7a
Hu Z, Wang J, Yu D, Soon J, de Kleijn D, Foo R, et al. Aberrant Splicing Promotes Proteasomal Degradation of L-type CaV1.2 Calcium Channels by Competitive Binding for CaVβ Subunits in Cardiac Hypertrophy. Sci Rep. 2016;6:35247 pubmed 出版商
  • 免疫印迹; 人类; 1:500; 图 2c
Helms A, Alvarado F, Yob J, Tang V, Pagani F, Russell M, et al. Genotype-Dependent and -Independent Calcium Signaling Dysregulation in Human Hypertrophic Cardiomyopathy. Circulation. 2016;134:1738-1748 pubmed
  • 免疫组化-石蜡切片; 豚鼠; 1:50; 图 6
Reyes García J, Flores Soto E, Solís Chagoyán H, Sommer B, Díaz Hernández V, García Hernández L, et al. Tumor Necrosis Factor Alpha Inhibits L-Type Ca(2+) Channels in Sensitized Guinea Pig Airway Smooth Muscle through ERK 1/2 Pathway. Mediators Inflamm. 2016;2016:5972302 pubmed 出版商
Liu D, Yang M, Yao Y, He S, Wang Y, Cao Z, et al. Cardiac Fibroblasts Promote Ferroptosis in Atrial Fibrillation by Secreting Exo-miR-23a-3p Targeting SLC7A11. Oxid Med Cell Longev. 2022;2022:3961495 pubmed 出版商
Yang Y, Yu Z, Geng J, Liu M, Liu N, Li P, et al. Cytosolic peptides encoding CaV1 C-termini downregulate the calcium channel activity-neuritogenesis coupling. Commun Biol. 2022;5:484 pubmed 出版商
Mu xf1 oz Montero A, de Pascual R, S xe1 ez Mas A, Colmena I, Gand xed a L. Alterations of the Sympathoadrenal Axis Related to the Development of Alzheimer's Disease in the 3xTg Mouse Model. Biology (Basel). 2022;11: pubmed 出版商
Fang Y, Li Q, Li X, Luo G, Kuang S, Luo X, et al. Piezo1 Participated in Decreased L-Type Calcium Current Induced by High Hydrostatic Pressure via. CaM/Src/Pitx2 Activation in Atrial Myocytes. Front Cardiovasc Med. 2022;9:842885 pubmed 出版商
Wang C, Horigane S, Wakamori M, Ueda S, Kawabata T, Fujii H, et al. Identification of ultra-rare disruptive variants in voltage-gated calcium channel-encoding genes in Japanese samples of schizophrenia and autism spectrum disorder. Transl Psychiatry. 2022;12:84 pubmed 出版商
El Refaey M, Coles S, Musa H, Stevens T, Wallace M, Murphy N, et al. Altered Expression of Zonula occludens-1 Affects Cardiac Na+ Channels and Increases Susceptibility to Ventricular Arrhythmias. Cells. 2022;11: pubmed 出版商
Alarcón Martínez L, Shiga Y, Villafranca Baughman D, Belforte N, Quintero H, Dotigny F, et al. Pericyte dysfunction and loss of interpericyte tunneling nanotubes promote neurovascular deficits in glaucoma. Proc Natl Acad Sci U S A. 2022;119: pubmed 出版商
Al Katat A, Zhao J, Calderone A, Parent L. Sympathetic Stimulation Upregulates the Ca2+ Channel Subunit, CaVα2δ1, via the β1 and ERK 1/2 Pathway in Neonatal Ventricular Cardiomyocytes. Cells. 2022;11: pubmed 出版商
Lee S, Yeh P, Yeh H. L-Type Calcium Channels Contribute to Ethanol-Induced Aberrant Tangential Migration of Primordial Cortical GABAergic Interneurons in the Embryonic Medial Prefrontal Cortex. Eneuro. 2022;9: pubmed 出版商
Cruz García Y, Barkovits K, Kohlhaas M, Pickel S, Gulentz M, Heindl C, et al. Nanoenviroments of the β-Subunit of L-Type Voltage-Gated Calcium Channels in Adult Cardiomyocytes. Front Cell Dev Biol. 2021;9:724778 pubmed 出版商
Kabakov A, Sengun E, Lu Y, Roder K, Bronk P, Baggett B, et al. Three-Week-Old Rabbit Ventricular Cardiomyocytes as a Novel System to Study Cardiac Excitation and EC Coupling. Front Physiol. 2021;12:672360 pubmed 出版商
Shen L, Wang Z, Wang R, Chen X, Cheng S. Upregulation of the P2X7 receptor promotes Ca2+ accumulation and inflammatory response in post-stroke depression. Am J Transl Res. 2021;13:10276-10287 pubmed
Garcia Elias A, Tajes M, Ya xf1 ez Bisbe L, Enjuanes C, Com xed n Colet J, Serra S, et al. Atrial Fibrillation in Heart Failure Is Associated with High Levels of Circulating microRNA-199a-5p and 22-5p and a Defective Regulation of Intracellular Calcium and Cell-to-Cell Communication. Int J Mol Sci. 2021;22: pubmed 出版商
Lotteau S, Zhang R, Hazan A, Grabar C, Gonzalez D, Aynaszyan S, et al. Acute Genetic Ablation of Cardiac Sodium/Calcium Exchange in Adult Mice: Implications for Cardiomyocyte Calcium Regulation, Cardioprotection, and Arrhythmia. J Am Heart Assoc. 2021;10:e019273 pubmed 出版商
Liu M, Liu H, Parthiban P, Kang G, Shi G, Feng F, et al. Inhibition of the unfolded protein response reduces arrhythmia risk after myocardial infarction. J Clin Invest. 2021;131: pubmed 出版商
Murakami M, Murakami A, Matsuzaki Y, Sawamura D, Ohba T, Miyoshi I, et al. Attenuated β-adrenergic response in calcium/calmodulin-dependent protein kinase IV-knockout mice. PLoS ONE. 2021;16:e0249932 pubmed 出版商
Ito J, Minemura T, W xe4 lchli S, Niimi T, Fujihara Y, Kuroda S, et al. Id2 Represses Aldosterone-Stimulated Cardiac T-Type Calcium Channels Expression. Int J Mol Sci. 2021;22: pubmed 出版商
Wang S, Goguadze N, Kimura Y, Yasui Y, Pan B, Wang T, et al. Genomic Action of Sigma-1 Receptor Chaperone Relates to Neuropathic Pain. Mol Neurobiol. 2021;58:2523-2541 pubmed 出版商
Matchkov V, Black Joergensen H, Kamaev D, Hoegh Jensen A, Beck H, Skryabin B, et al. A paradoxical increase of force development in saphenous and tail arteries from heterozygous ANO1 knockout mice. Physiol Rep. 2020;8:e14645 pubmed 出版商
Ma X, Liu B, Zhao C. Modulation of Ca2+-induced Ca2+ release by ubiquitin protein ligase E3 component n-recognin UBR3 and 6 in cardiac myocytes. Channels (Austin). 2020;14:326-335 pubmed 出版商
Ednie A, Bennett E. Intracellular O-linked glycosylation directly regulates cardiomyocyte L-type Ca2+ channel activity and excitation-contraction coupling. Basic Res Cardiol. 2020;115:59 pubmed 出版商
Viola H, Shah A, Johnstone V, Cserne Szappanos H, Hodson M, Hool L. Characterization and validation of a preventative therapy for hypertrophic cardiomyopathy in a murine model of the disease. Proc Natl Acad Sci U S A. 2020;117:23113-23124 pubmed 出版商
Kilfoil P, Lotteau S, Zhang R, Yue X, Aynaszyan S, Solymani R, et al. Distinct features of calcium handling and β-adrenergic sensitivity in heart failure with preserved versus reduced ejection fraction. J Physiol. 2020;598:5091-5108 pubmed 出版商
Dickerson M, Dadi P, Butterworth R, Nakhe A, Graff S, Zaborska K, et al. Tetraspanin-7 regulation of L-type voltage-dependent calcium channels controls pancreatic β-cell insulin secretion. J Physiol. 2020;598:4887-4905 pubmed 出版商
Jahan K, Shi J, Greenberg H, Khavandi S, Baudel M, Barrese V, et al. MARCKS mediates vascular contractility through regulating interactions between voltage-gated Ca2+ channels and PIP2. Vascul Pharmacol. 2020;132:106776 pubmed 出版商
Li J, Agvanian S, Zhou K, Shaw R, Hong T. Exogenous Cardiac Bridging Integrator 1 Benefits Mouse Hearts With Pre-existing Pressure Overload-Induced Heart Failure. Front Physiol. 2020;11:708 pubmed 出版商
Li B, He X, Dong Z, Xuan K, Sun W, Gao L, et al. Ionomycin ameliorates hypophosphatasia via rescuing alkaline phosphatase deficiency-mediated L-type Ca2+ channel internalization in mesenchymal stem cells. Bone Res. 2020;8:19 pubmed 出版商
Yang H, Lin F, Yang H, Yu P, Huang S, Chen Y, et al. The effect of Sirt1 deficiency on Ca2+ and Na+ regulation in mouse ventricular myocytes. J Cell Mol Med. 2020;24:6762-6772 pubmed 出版商
Li J, Wang S, Zhang J, Liu Y, Zheng X, Ding F, et al. The CaMKII phosphorylation site Thr1604 in the CaV1.2 channel is involved in pathological myocardial hypertrophy in rats. Channels (Austin). 2020;14:151-162 pubmed 出版商
Zamora N, Cheli V, Santiago González D, Wan R, Paez P. Deletion of Voltage-Gated Calcium Channels in Astrocytes during Demyelination Reduces Brain Inflammation and Promotes Myelin Regeneration in Mice. J Neurosci. 2020;40:3332-3347 pubmed 出版商
Arow M, Waldman M, Yadin D, Nudelman V, Shainberg A, Abraham N, et al. Sodium-glucose cotransporter 2 inhibitor Dapagliflozin attenuates diabetic cardiomyopathy. Cardiovasc Diabetol. 2020;19:7 pubmed 出版商
Cheng W, Kao Y, Chen Y, Lin Y, Chen S, Chen Y. Macrophage migration inhibitory factor increases atrial arrhythmogenesis through CD74 signaling. Transl Res. 2020;216:43-56 pubmed 出版商
Cacheux M, Fauconnier J, Thireau J, Osseni A, Brocard J, Roux Buisson N, et al. Interplay between Triadin and Calsequestrin in the Pathogenesis of CPVT in the Mouse. Mol Ther. 2020;28:171-179 pubmed 出版商
Hamilton S, Polina I, Terentyeva R, Bronk P, Kim T, Roder K, et al. PKA phosphorylation underlies functional recruitment of sarcolemmal SK2 channels in ventricular myocytes from hypertrophic hearts. J Physiol. 2020;598:2847-2873 pubmed 出版商
Li Q, Zhu Z, Lu J, Chao Y, Zhou X, Huang Y, et al. Sleep deprivation of rats increases postsurgical expression and activity of L-type calcium channel in the dorsal root ganglion and slows recovery from postsurgical pain. Acta Neuropathol Commun. 2019;7:217 pubmed 出版商
An S, Gilani N, Huang Y, Muncan A, Zhang Y, Tang Y, et al. Adverse transverse-tubule remodeling in a rat model of heart failure is attenuated with low-dose triiodothyronine treatment. Mol Med. 2019;25:53 pubmed 出版商
Michels S, Dolga A, Braun M, Kisko T, Sungur A, Witt S, et al. Interaction of the Psychiatric Risk Gene Cacna1c With Post-weaning Social Isolation or Environmental Enrichment Does Not Affect Brain Mitochondrial Bioenergetics in Rats. Front Cell Neurosci. 2019;13:483 pubmed 出版商
Atsuta Y, Tomizawa R, Levin M, Tabin C. L-type voltage-gated Ca2+ channel CaV1.2 regulates chondrogenesis during limb development. Proc Natl Acad Sci U S A. 2019;116:21592-21601 pubmed 出版商
Van Opbergen C, Noorman M, Pfenniger A, Copier J, Vermij S, Li Z, et al. Plakophilin-2 Haploinsufficiency Causes Calcium Handling Deficits and Modulates the Cardiac Response Towards Stress. Int J Mol Sci. 2019;20: pubmed 出版商
Arrojo e Drigo R, Jacob S, García Prieto C, Zheng X, Fukuda M, Nhu H, et al. Structural basis for delta cell paracrine regulation in pancreatic islets. Nat Commun. 2019;10:3700 pubmed 出版商
Chen L, Zhang B, Yang L, Bai Y, Song J, Ge Y, et al. BMAL1 Disrupted Intrinsic Diurnal Oscillation in Rat Cerebrovascular Contractility of Simulated Microgravity Rats by Altering Circadian Regulation of miR-103/CaV1.2 Signal Pathway. Int J Mol Sci. 2019;20: pubmed 出版商
Morgenstern T, Park J, Fan Q, Colecraft H. A potent voltage-gated calcium channel inhibitor engineered from a nanobody targeted to auxiliary CaVβ subunits. elife. 2019;8: pubmed 出版商
Araki K, Araki A, Honda D, Izumoto T, Hashizume A, Hijikata Y, et al. TDP-43 regulates early-phase insulin secretion via CaV1.2-mediated exocytosis in islets. J Clin Invest. 2019;130:3578-3593 pubmed 出版商
Ikeda S, Matsushima S, Okabe K, Ikeda M, Ishikita A, Tadokoro T, et al. Blockade of L-type Ca2+ channel attenuates doxorubicin-induced cardiomyopathy via suppression of CaMKII-NF-κB pathway. Sci Rep. 2019;9:9850 pubmed 出版商
Wang X, Zhuo X, Gao J, Liu H, Lin F, Ma A. Neuregulin-1β Partially Improves Cardiac Function in Volume-Overload Heart Failure Through Regulation of Abnormal Calcium Handling. Front Pharmacol. 2019;10:616 pubmed 出版商
Fei D, Zhang Y, Wu J, Zhang H, Liu A, He X, et al. Cav 1.2 regulates osteogenesis of bone marrow-derived mesenchymal stem cells via canonical Wnt pathway in age-related osteoporosis. Aging Cell. 2019;18:e12967 pubmed 出版商
Lai Y, Zhu B, Sun F, Luo D, Ma Y, Luo B, et al. Estrogen receptor α promotes Cav1.2 ubiquitination and degradation in neuronal cells and in APP/PS1 mice. Aging Cell. 2019;18:e12961 pubmed 出版商
Machuki J, Zhang H, Geng J, Fu L, Adzika G, Wu L, et al. Estrogen regulation of cardiac cAMP-L-type Ca2+ channel pathway modulates sex differences in basal contraction and responses to β2AR-mediated stress in left ventricular apical myocytes. Cell Commun Signal. 2019;17:34 pubmed 出版商
Zhang D, Hu X, Li J, Liu J, Baks Te Bulte L, Wiersma M, et al. DNA damage-induced PARP1 activation confers cardiomyocyte dysfunction through NAD+ depletion in experimental atrial fibrillation. Nat Commun. 2019;10:1307 pubmed 出版商
Herzog K, IJlst L, van Cruchten A, van Roermund C, Kulik W, Wanders R, et al. An UPLC-MS/MS Assay to Measure Glutathione as Marker for Oxidative Stress in Cultured Cells. Metabolites. 2019;9: pubmed 出版商
Alvarado F, Bos J, Yuchi Z, Valdivia C, Hernández J, Zhao Y, et al. Cardiac hypertrophy and arrhythmia in mice induced by a mutation in ryanodine receptor 2. JCI Insight. 2019;5: pubmed 出版商
Chung Y, Luo A, Park K, Loonat A, Lakhal Littleton S, Robbins P, et al. Iron-deficiency anemia reduces cardiac contraction by downregulating RyR2 channels and suppressing SERCA pump activity. JCI Insight. 2019;4: pubmed 出版商
Guan Y, Gao X, Tang Q, Huang L, Gao S, Yu S, et al. Nucleoporin 107 facilitates the nuclear export of Scn5a mRNA to regulate cardiac bioelectricity. J Cell Mol Med. 2019;23:1448-1457 pubmed 出版商
Liang D, Wu Y, Zhou L, Chen Y, Liu H, Xie D, et al. LRP5 controls cardiac QT interval by modulating the metabolic homeostasis of L-type calcium channel. Int J Cardiol. 2019;275:120-128 pubmed 出版商
Ednie A, Deng W, Yip K, Bennett E. Reduced myocyte complex N-glycosylation causes dilated cardiomyopathy. FASEB J. 2019;33:1248-1261 pubmed 出版商
Brandenburg S, Pawlowitz J, Fakuade F, Kownatzki Danger D, Kohl T, Mitronova G, et al. Axial Tubule Junctions Activate Atrial Ca2+ Release Across Species. Front Physiol. 2018;9:1227 pubmed 出版商
Basheer W, Fu Y, Shimura D, Xiao S, Agvanian S, Hernandez D, et al. Stress response protein GJA1-20k promotes mitochondrial biogenesis, metabolic quiescence, and cardioprotection against ischemia/reperfusion injury. JCI Insight. 2018;3: pubmed 出版商
Wright P, Sanchez Alonso J, Lucarelli C, Alvarez Laviada A, Poulet C, Bello S, et al. Partial Mechanical Unloading of the Heart Disrupts L-Type Calcium Channel and Beta-Adrenoceptor Signaling Microdomains. Front Physiol. 2018;9:1302 pubmed 出版商
Dos Santos L, Antonio E, Serra A, Yoshizaki A, Seibt L, Silva F, et al. Atrial fibrillation promotion in a rat model of heart failure induced by left ventricle radiofrequency ablation. Int J Cardiol Heart Vasc. 2018;21:22-28 pubmed 出版商
Lai Y, Li N, Lawrence W, Wang S, Levine A, Burchhardt D, et al. Myocardial remodeling and susceptibility to ventricular tachycardia in a model of chronic epilepsy. Epilepsia Open. 2018;3:213-223 pubmed 出版商
Ikeda Y, Zabbarova I, Birder L, Wipf P, Getchell S, Tyagi P, et al. Relaxin-2 therapy reverses radiation-induced fibrosis and restores bladder function in mice. Neurourol Urodyn. 2018;37:2441-2451 pubmed 出版商
Kamijo S, Ishii Y, Horigane S, Suzuki K, Ohkura M, Nakai J, et al. A Critical Neurodevelopmental Role for L-Type Voltage-Gated Calcium Channels in Neurite Extension and Radial Migration. J Neurosci. 2018;38:5551-5566 pubmed 出版商
Michels S, Ganjam G, Martins H, Schratt G, Wohr M, Schwarting R, et al. Downregulation of the psychiatric susceptibility gene Cacna1c promotes mitochondrial resilience to oxidative stress in neuronal cells. Cell Death Discov. 2018;4:54 pubmed 出版商
Kisko T, Braun M, Michels S, Witt S, Rietschel M, Culmsee C, et al. Cacna1c haploinsufficiency leads to pro-social 50-kHz ultrasonic communication deficits in rats. Dis Model Mech. 2018;11: pubmed 出版商
Briot J, Mailhot O, Bourdin B, Tétreault M, Najmanovich R, Parent L. A three-way inter-molecular network accounts for the CaVα2δ1-induced functional modulation of the pore-forming CaV1.2 subunit. J Biol Chem. 2018;293:7176-7188 pubmed 出版商
Xia P, Li L, Qi R, Shi J, Ju W, Chen M. Electrical and histological remodeling of the pulmonary vein in 2K1C hypertensive rats: Indication of initiation and maintenance of atrial fibrillation. Anatol J Cardiol. 2018;19:169-175 pubmed 出版商
Bi C, Tham D, Perronnet C, Joshi B, Nabi I, Moukhles H. The Oxidative Stress-Induced Increase in the Membrane Expression of the Water-Permeable Channel Aquaporin-4 in Astrocytes Is Regulated by Caveolin-1 Phosphorylation. Front Cell Neurosci. 2017;11:412 pubmed 出版商
Dong L, Cheng X, Zhou L, Hu Y. Calcium channels are involved in EphB/ephrinB reverse signaling?induced apoptosis in a rat chronic ocular hypertension model. Mol Med Rep. 2017;: pubmed 出版商
Chen X, Weber C, Farrell E, Alvarado F, Zhao Y, Gomez A, et al. Sorcin ablation plus β-adrenergic stimulation generate an arrhythmogenic substrate in mouse ventricular myocytes. J Mol Cell Cardiol. 2018;114:199-210 pubmed 出版商
Okuyama Y, Hirawa N, Fujita M, Fujiwara A, Ehara Y, Yatsu K, et al. The effects of anti-hypertensive drugs and the mechanism of hypertension in vascular smooth muscle cell-specific ATP2B1 knockout mice. Hypertens Res. 2017;: pubmed 出版商
Sahu G, Asmara H, Zhang F, Zamponi G, Turner R. Activity-Dependent Facilitation of CaV1.3 Calcium Channels Promotes KCa3.1 Activation in Hippocampal Neurons. J Neurosci. 2017;37:11255-11270 pubmed 出版商
Bourdin B, Briot J, Tétreault M, Sauve R, Parent L. Negatively charged residues in the first extracellular loop of the L-type CaV1.2 channel anchor the interaction with the CaV?2?1 auxiliary subunit. J Biol Chem. 2017;292:17236-17249 pubmed 出版商
Hermosilla T, Encina M, Morales D, Moreno C, Conejeros C, Alfaro Valdés H, et al. Prolonged AT1R activation induces CaV1.2 channel internalization in rat cardiomyocytes. Sci Rep. 2017;7:10131 pubmed 出版商
Papp R, Bett G, Lis A, Rasmusson R, Baczkó I, Varro A, et al. Genomic upregulation of cardiac Cav1.2? and NCX1 by estrogen in women. Biol Sex Differ. 2017;8:26 pubmed 出版商
Buonarati O, Henderson P, Murphy G, Horne M, Hell J. Proteolytic processing of the L-type Ca 2+ channel alpha 11.2 subunit in neurons. F1000Res. 2017;6:1166 pubmed 出版商
Cerrone M, Montnach J, Lin X, Zhao Y, Zhang M, Agullo Pascual E, et al. Plakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm. Nat Commun. 2017;8:106 pubmed 出版商
Espinal Enríquez J, Priego Espinosa D, Darszon A, Beltrán C, Martínez Mekler G. Network model predicts that CatSper is the main Ca2+ channel in the regulation of sea urchin sperm motility. Sci Rep. 2017;7:4236 pubmed 出版商
Feridooni H, Kane A, Ayaz O, Boroumandi A, Polidovitch N, Tsushima R, et al. The impact of age and frailty on ventricular structure and function in C57BL/6J mice. J Physiol. 2017;595:3721-3742 pubmed 出版商
Segura E, Bourdin B, Tétreault M, Briot J, Allen B, Mayer G, et al. Proteolytic cleavage of the hydrophobic domain in the CaV?2?1 subunit improves assembly and activity of cardiac CaV1.2 channels. J Biol Chem. 2017;292:11109-11124 pubmed 出版商
Liu X, Shen Y, Xie J, Bao H, Cao Q, Wan R, et al. A mutation in the CACNA1C gene leads to early repolarization syndrome with incomplete penetrance: A Chinese family study. PLoS ONE. 2017;12:e0177532 pubmed 出版商
Røe A, Aronsen J, Skårdal K, Hamdani N, Linke W, Danielsen H, et al. Increased passive stiffness promotes diastolic dysfunction despite improved Ca2+ handling during left ventricular concentric hypertrophy. Cardiovasc Res. 2017;113:1161-1172 pubmed 出版商
Ma Y, Wang J, Bai Y, Liu M, Xie M, Dai Z. Salidroside contributes to reducing blood pressure and alleviating cerebrovascular contractile activity in diabetic Goto-Kakizaki Rats by inhibition of L-type calcium channel in smooth muscle cells. BMC Pharmacol Toxicol. 2017;18:30 pubmed 出版商
Varodayan F, de Guglielmo G, Logrip M, George O, Roberto M. Alcohol Dependence Disrupts Amygdalar L-Type Voltage-Gated Calcium Channel Mechanisms. J Neurosci. 2017;37:4593-4603 pubmed 出版商
Kashihara T, Nakada T, Kojima K, Takeshita T, Yamada M. Angiotensin II activates CaV 1.2 Ca2+ channels through ?-arrestin2 and casein kinase 2 in mouse immature cardiomyocytes. J Physiol. 2017;595:4207-4225 pubmed 出版商
Bavley C, Fischer D, Rizzo B, Rajadhyaksha A. Cav1.2 channels mediate persistent chronic stress-induced behavioral deficits that are associated with prefrontal cortex activation of the p25/Cdk5-glucocorticoid receptor pathway. Neurobiol Stress. 2017;7:27-37 pubmed 出版商
Oz S, Pankonien I, Belkacemi A, Flockerzi V, Klussmann E, Haase H, et al. Protein kinase A regulates C-terminally truncated CaV 1.2 in Xenopus oocytes: roles of N- and C-termini of the ?1C subunit. J Physiol. 2017;595:3181-3202 pubmed 出版商
Jeong M, Kim H, Pyun J, Choi K, Lee D, Solhjoo S, et al. Cdon deficiency causes cardiac remodeling through hyperactivation of WNT/β-catenin signaling. Proc Natl Acad Sci U S A. 2017;114:E1345-E1354 pubmed 出版商
Bond R, Bryant S, Watson J, Hancox J, Orchard C, James A. Reduced density and altered regulation of rat atrial L-type Ca2+ current in heart failure. Am J Physiol Heart Circ Physiol. 2017;312:H384-H391 pubmed 出版商
Cheli V, Santiago González D, Namgyal Lama T, Spreuer V, Handley V, Murphy G, et al. Conditional Deletion of the L-Type Calcium Channel Cav1.2 in Oligodendrocyte Progenitor Cells Affects Postnatal Myelination in Mice. J Neurosci. 2016;36:10853-10869 pubmed
Philippart F, Destreel G, Merino Sepúlveda P, Henny P, Engel D, Seutin V. Differential Somatic Ca2+ Channel Profile in Midbrain Dopaminergic Neurons. J Neurosci. 2016;36:7234-45 pubmed 出版商
Willis B, Pandit S, Ponce Balbuena D, Zarzoso M, Guerrero Serna G, Limbu B, et al. Constitutive Intracellular Na+ Excess in Purkinje Cells Promotes Arrhythmogenesis at Lower Levels of Stress Than Ventricular Myocytes From Mice With Catecholaminergic Polymorphic Ventricular Tachycardia. Circulation. 2016;133:2348-59 pubmed 出版商
Forostyak O, Butenko O, Anderova M, Forostyak S, Sykova E, Verkhratsky A, et al. Specific profiles of ion channels and ionotropic receptors define adipose- and bone marrow derived stromal cells. Stem Cell Res. 2016;16:622-34 pubmed 出版商
Schilling J, Horikawa Y, Zemljic Harpf A, Vincent K, Tyan L, Yu J, et al. Electrophysiology and metabolism of caveolin-3-overexpressing mice. Basic Res Cardiol. 2016;111:28 pubmed 出版商
Fu Y, Shaw S, Naami R, Vuong C, Basheer W, Guo X, et al. Isoproterenol Promotes Rapid Ryanodine Receptor Movement to Bridging Integrator 1 (BIN1)-Organized Dyads. Circulation. 2016;133:388-97 pubmed 出版商
Walton R, Jones S, Rostron K, Kayani A, Close G, McArdle A, et al. Interactions of Short-Term and Chronic Treadmill Training With Aging of the Left Ventricle of the Heart. J Gerontol A Biol Sci Med Sci. 2016;71:1005-13 pubmed 出版商
图像
图像 1 :
Alomone Labs ACC-003 图像 1
Western blot analysis of rat brain membranes: - 1. Anti-CaV1.2 (CACNA1C) Antibody (#ACC-003), (1:200).2. Anti-CaV1.2 (CACNA1C) Antibody, preincubated with Cav1.2/CACNA1C Blocking Peptide (#BLP-CC003).
图像 2 :
Alomone Labs ACC-003 图像 2
Expression of CaV1.2 in mouse cerebellum - Immunohistochemical staining of mouse cerebellum with Anti-CaV1.2 (CACNA1C) Antibody (#ACC-003). A. CaV1.2 (red) appears in Purkinje cells (horizontal arrows) and is distributed diffusely in the molecular layer (Mol) including in Purkinje dendrites (vertical arrows). B. Staining of Purkinje nerve cells with mouse anti-Calbindin 28K (green) demonstrates the location of dendrites in the molecular layer. C. Merged image of panels A and B.
产品信息
SKU号 :
ACC-003_1_25_mcl
ParentSKU :
ACC-003
Taxonomy Node :
Primary Antibody>Intracellular>Non-Labeled
Action :
Insert
产品名称 :
抗Cav1.2(CACNA1C)抗体
产品描述 :
Anti-CaV1.2 (CACNA1C) Antibody (#ACC-003) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot, immunoprecipitation, immunohistochemistry, immunocytochemistry, and indirect flow cytometry applications. It has been designed to recognize CaV1.2 from mouse, rat, and human samples.
Short Description :
A Rabbit Polyclonal Antibody to CaV1.2 (CACNA1C) Channel
Negative Control :
BLP-CC003
同义词 :
CaV1.2, Voltage-dependent L-type Ca2+ channel subunit alpha1C, Cacna1c
靶标名 :
CaV1.2 (CACNA1C) Channel
Primary Category (Old) :
Ion Channels > Ca2+ Signaling > Voltage-Gated Ca2+ Channels > Antibodies to CaV Channels
标记/共轭标签 :
未共轭
应用 :
免疫细胞化学, IF, IFC, 免疫组化, 免疫沉淀, 免疫印迹
宿主 :
克隆性 :
多克隆
抗体亚型 :
兔IgG
基因符号 :
CACNA1C
反应物种 :
人类(试验);小鼠(试验);大鼠(试验)
同源 :
Mouse - identical; guinea pig - 17/18 amino acid residues identical; human, rabbit - 16/18 amino acid residues identical.
靶标/背景信息 :
All L-type calcium channels are encoded by one of the CaV1 channel genes. These channels play a major role as a Ca2+ entry pathway in skeletal, cardiac and smooth muscles as well as in neurons, endocrine cells and possibly in non-excitable cells such as hematopoetic and epithelial cells. All CaV1 channels are influenced by dihydropyridines (DHP) and are also referred to as DHP receptors. While the CaV1.1 and CaV1.4 isoforms are expressed in restricted tissues (skeletal muscle and retina, respectively), the expression of CaV1.2 is ubiquitous and CaV1.3 channels are found in the heart, brain and pancreas. Several peptidyl toxins are described that are specific L-type channel blockers, but so far no selective blocker for one of the CaV1 isoforms have been described. These include the Mamba toxins Calcicludine (#SPC-650), Calciseptine (#C-500) and FS-2 (#F-700).
免疫原 :
合成肽
区域 :
intracellular
Loop :
Intracellular loop between domains II and III
序列 :
(C)TTKINMDDLQPSENEDKS, corresponding to amino acid residues 848-865 of rat CaV1.2
序列文本 :
Peptide (C)TTKINMDDLQPSENEDKS, corresponding to amino acid residues 848-865 of rat CaV1.2 (Accession P22002). Intracellular loop between domains II and III.
Primary Size (Size+Units) :
1 X 25 mcl
浓度 :
0.8毫克/毫升
浓度 :
08毫克/毫升
缓冲液 :
磷酸盐缓冲液(PBS)
pH值 :
pH值7.4
防腐剂 :
1% BSA, 0.05% NaN3 (% of reconstituted antibody)
Additive(s) :
Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
格式(液体/冻干) :
冻干粉末
纯化来源(杂交瘤细胞, 腹水 :
Affinity purified on immobilized antigen
储存温度 :
-20°C
UniProt数据库 :
P22002
Top Related :
ACC-005, ASC-005, ACC-002, APC-022, APC-052
储存和重组 :
Reconstitution: 1 X 25 mcl double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C, as long as it is in its original form, it can last a minimum of 3 years this way. The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
包装规格 :
1
产品规格/规格 :
25
单位 :
mcl
标价美国[美元] :
425美元
更多信息或购买 :
公司信息
Alomone Labs
Jerusalem BioPark (JBP), Hadassah Ein Kerem
P.O. Box 4287
Jerusalem 9104201
info@alomone.com
http://www.alomone.com
972-2-587-2202
公司总部: 以色列
Alomone Labs公司成立于1989年,在离子通道、GPCR及神经信号通路研究等领域占据全球领先地位。