产品简要
公司名称 :
Alomone Labs
产品类型 :
抗体
产品名称 :
抗TRPC6抗体
目录 :
ACC-017
规格 :
1 X 25 mcl
价格 :
425美元
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠,
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 42
出版应用/物种/样本/稀释参考文献
  • 免疫组化-石蜡切片; 小鼠; 1:100; 图 4b
  • 免疫细胞化学; 人类; 图 4e
Chen Q, Zhou Y, Zhou L, Fu Z, Yang C, Zhao L, et al. TRPC6-dependent Ca2+ signaling mediates airway inflammation in response to oxidative stress via ERK pathway. Cell Death Dis. 2020;11:170 pubmed 出版商
  • 免疫印迹; 小鼠; 1:800; 图 5a
Huang M, Lee K, Kim K, Ahn M, Cho C, Kim D, et al. The maintenance ability and Ca2+ availability of skeletal muscle are enhanced by sildenafil. Exp Mol Med. 2016;48:e278 pubmed 出版商
  • 免疫沉淀; 犬; 1:1000; 图 7c
  • 免疫印迹; 人类; 1:1000; 图 10
Hammers D, Sleeper M, Forbes S, Shima A, Walter G, Sweeney H. Tadalafil Treatment Delays the Onset of Cardiomyopathy in Dystrophin-Deficient Hearts. J Am Heart Assoc. 2016;5: pubmed 出版商
Servello D, Abdinghoff J, Grissmer A, Tschernig T. Transient receptor potential channel 6 in human skeletal muscle fibers: Investigation in fresh and conserved tissue samples. Biomed Rep. 2022;17:60 pubmed 出版商
Abdinghoff J, Servello D, Jacobs T, Beckmann A, Tschernig T. Evaluation of the presence of TRPC6 channels in human vessels: A pilot study using immunohistochemistry. Biomed Rep. 2022;16:42 pubmed 出版商
He C, Li Q, Cui Y, Gao P, Shu W, Zhou Q, et al. Recurrent moderate hypoglycemia accelerates the progression of Alzheimer's disease through impairment of the TRPC6/GLUT3 pathway. JCI Insight. 2022;7: pubmed 出版商
Lee T, Chung C, Lee T, Lin Y, Kao Y, Chen Y. Fibroblast Growth Factor 23 Stimulates Cardiac Fibroblast Activity through Phospholipase C-Mediated Calcium Signaling. Int J Mol Sci. 2021;23: pubmed 出版商
Jeong S, Oh M, Choi J, Woo J, Lee E. Calsequestrin 1 Is an Active Partner of Stromal Interaction Molecule 2 in Skeletal Muscle. Cells. 2021;10: pubmed 出版商
t Hart D, Li J, van der Vlag J, Nijenhuis T. Repurposing Riociguat to Target a Novel Paracrine Nitric Oxide-TRPC6 Pathway to Prevent Podocyte Injury. Int J Mol Sci. 2021;22: pubmed 出版商
Hou X, Huang M, Zeng X, Zhang Y, Sun A, Wu Q, et al. The Role of TRPC6 in Renal Ischemia/Reperfusion and Cellular Hypoxia/Reoxygenation Injuries. Front Mol Biosci. 2021;8:698975 pubmed 出版商
Kawade A, Yamamura A, Fujiwara M, Kobayashi S, Mori S, Horii C, et al. Comparative analysis of age in monocrotaline-induced pulmonary hypertensive rats. J Pharmacol Sci. 2021;147:81-85 pubmed 出版商
Golosova D, Palygin O, Bohovyk R, Klemens C, Levchenko V, Spires D, et al. Role of opioid signaling in kidney damage during the development of salt-induced hypertension. Life Sci Alliance. 2020;3: pubmed 出版商
Gu L, Ge H, Zhao L, Wang Y, Zhang F, Tang H, et al. Huangkui Capsule Ameliorates Renal Fibrosis in a Unilateral Ureteral Obstruction Mouse Model Through TRPC6 Dependent Signaling Pathways. Front Pharmacol. 2020;11:996 pubmed 出版商
Mei L, Zheng Y, Song T, Yadav V, Joseph L, Truong L, et al. Rieske iron-sulfur protein induces FKBP12.6/RyR2 complex remodeling and subsequent pulmonary hypertension through NF-κB/cyclin D1 pathway. Nat Commun. 2020;11:3527 pubmed 出版商
Zhang X, Luo D, Bai X, Ding H, Liu M, Deng J, et al. Upregulation of TRPC6 Mediated by PAX6 Hypomethylation Is Involved in the Mechanical Allodynia Induced by Chemotherapeutics in Dorsal Root Ganglion. Int J Neuropsychopharmacol. 2020;23:257-267 pubmed 出版商
Choi J, Huang M, Hyun C, Oh M, Lee K, Cho C, et al. A muscular hypotonia-associated STIM1 mutant at R429 induces abnormalities in intracellular Ca2+ movement and extracellular Ca2+ entry in skeletal muscle. Sci Rep. 2019;9:19140 pubmed 出版商
Yap J, Tai Y, Fröhlich J, Fong C, Yin J, Foo Z, et al. Ambient and supplemental magnetic fields promote myogenesis via a TRPC1-mitochondrial axis: evidence of a magnetic mitohormetic mechanism. FASEB J. 2019;33:12853-12872 pubmed 出版商
Paez Espinosa E, Lin O, Karim Z, Alshbool F, Khasawneh F. Mouse transient receptor potential channel type 6 selectively regulates agonist-induced platelet function. Biochem Biophys Rep. 2019;20:100685 pubmed 出版商
Bernardini M, Brossa A, Chinigo G, Grolez G, Trimaglio G, Allart L, et al. Transient Receptor Potential Channel Expression Signatures in Tumor-Derived Endothelial Cells: Functional Roles in Prostate Cancer Angiogenesis. Cancers (Basel). 2019;11: pubmed 出版商
Numaga Tomita T, Shimauchi T, Oda S, Tanaka T, Nishiyama K, Nishimura A, et al. TRPC6 regulates phenotypic switching of vascular smooth muscle cells through plasma membrane potential-dependent coupling with PTEN. FASEB J. 2019;33:9785-9796 pubmed 出版商
Chen X, Taylor Nguyen N, Riley A, Herring B, White F, Obukhov A. The TRPC6 inhibitor, larixyl acetate, is effective in protecting against traumatic brain injury-induced systemic endothelial dysfunction. J Neuroinflammation. 2019;16:21 pubmed 出版商
Kim E, Hassanzadeh Khayyat N, Dryer S. Mechanisms underlying modulation of podocyte TRPC6 channels by suPAR: Role of NADPH oxidases and Src family tyrosine kinases. Biochim Biophys Acta Mol Basis Dis. 2018;1864:3527-3536 pubmed 出版商
Hou X, Xiao H, Zhang Y, Zeng X, Huang M, Chen X, et al. Transient receptor potential channel 6 knockdown prevents apoptosis of renal tubular epithelial cells upon oxidative stress via autophagy activation. Cell Death Dis. 2018;9:1015 pubmed 出版商
Dominguez Rodriguez A, Mayoral Gonzalez I, Ávila Médina J, de Rojas de Pedro E, Calderón Sanchez E, Diaz I, et al. Urocortin-2 Prevents Dysregulation of Ca2+ Homeostasis and Improves Early Cardiac Remodeling After Ischemia and Reperfusion. Front Physiol. 2018;9:813 pubmed 出版商
Sunggip C, Shimoda K, Oda S, Tanaka T, Nishiyama K, Mangmool S, et al. TRPC5-eNOS Axis Negatively Regulates ATP-Induced Cardiomyocyte Hypertrophy. Front Pharmacol. 2018;9:523 pubmed 出版商
Ilatovskaya D, Blass G, Palygin O, Levchenko V, Pavlov T, Grzybowski M, et al. A NOX4/TRPC6 Pathway in Podocyte Calcium Regulation and Renal Damage in Diabetic Kidney Disease. J Am Soc Nephrol. 2018;29:1917-1927 pubmed 出版商
Kim E, Yazdizadeh Shotorbani P, Dryer S. Trpc6 inactivation confers protection in a model of severe nephrosis in rats. J Mol Med (Berl). 2018;96:631-644 pubmed 出版商
Zhang L, Chen X, Qin H, Jiang L, Qin Y. ATRA attenuate proteinuria via downregulation of TRPC6 in glomerulosclerosis rats induced by adriamycin. Ren Fail. 2018;40:266-272 pubmed 出版商
Oh M, Lee K, Huang M, Kim J, Kim D, Cho C, et al. STIM2 regulates both intracellular Ca2+ distribution and Ca2+ movement in skeletal myotubes. Sci Rep. 2017;7:17936 pubmed 出版商
Ohba T, Watanabe H, Murakami M, Iino K, Adachi T, Baba Y, et al. Stromal interaction molecule 1 haploinsufficiency causes maladaptive response to pressure overload. PLoS ONE. 2017;12:e0187950 pubmed 出版商
Zhang L, Ji T, Wang Q, Meng K, Zhang R, Yang H, et al. Calcium-Sensing Receptor Stimulation in Cultured Glomerular Podocytes Induces TRPC6-Dependent Calcium Entry and RhoA Activation. Cell Physiol Biochem. 2017;43:1777-1789 pubmed 出版商
Hong W, Peng G, Hao B, Liao B, Zhao Z, Zhou Y, et al. Nicotine-Induced Airway Smooth Muscle Cell Proliferation Involves TRPC6-Dependent Calcium Influx Via α7 nAChR. Cell Physiol Biochem. 2017;43:986-1002 pubmed 出版商
Urban N, Neuser S, Hentschel A, Köhling S, Rademann J, Schaefer M. Pharmacological inhibition of focal segmental glomerulosclerosis-related, gain of function mutants of TRPC6 channels by semi-synthetic derivatives of larixol. Br J Pharmacol. 2017;174:4099-4122 pubmed 出版商
Kim E, Roshanravan H, Dryer S. Changes in podocyte TRPC channels evoked by plasma and sera from patients with recurrent FSGS and by putative glomerular permeability factors. Biochim Biophys Acta Mol Basis Dis. 2017;1863:2342-2354 pubmed 出版商
He X, Li S, Liu B, Susperreguy S, Formoso K, Yao J, et al. Major contribution of the 3/6/7 class of TRPC channels to myocardial ischemia/reperfusion and cellular hypoxia/reoxygenation injuries. Proc Natl Acad Sci U S A. 2017;114:E4582-E4591 pubmed 出版商
Liu N, Zhuang Y, Zhou Z, Zhao J, Chen Q, Zheng J. NF-?B dependent up-regulation of TRPC6 by A? in BV-2 microglia cells increases COX-2 expression and contributes to hippocampus neuron damage. Neurosci Lett. 2017;651:1-8 pubmed 出版商
Krauszman A, Mak T, Szaszi K, Kuebler W. Role of phosphatase and tensin homolog in hypoxic pulmonary vasoconstriction. Cardiovasc Res. 2017;113:869-878 pubmed 出版商
Jadeja R, Thounaojam M, Khurana S. Characterization of pressure-mediated vascular tone in resistance arteries from bile duct-ligated rats. Oncotarget. 2017;8:30706-30722 pubmed 出版商
Yang L, Liu B, Lu X, Yan Y, Zhai Y, Bao Q, et al. Inhibition of TRPC6 reduces non-small cell lung cancer cell proliferation and invasion. Oncotarget. 2017;8:5123-5134 pubmed 出版商
Alvarez Miguel I, Cidad P, Pérez García M, Lopez Lopez J. Differences in TRPC3 and TRPC6 channels assembly in mesenteric vascular smooth muscle cells in essential hypertension. J Physiol. 2017;595:1497-1513 pubmed 出版商
Jiang Q, Lu W, Yang K, Hadadi C, Fu X, Chen Y, et al. Sodium tanshinone IIA sulfonate inhibits hypoxia-induced enhancement of SOCE in pulmonary arterial smooth muscle cells via the PKG-PPAR-? signaling axis. Am J Physiol Cell Physiol. 2016;311:C136-49 pubmed 出版商
Urban N, Wang L, Kwiek S, Rademann J, Kuebler W, Schaefer M. Identification and Validation of Larixyl Acetate as a Potent TRPC6 Inhibitor. Mol Pharmacol. 2016;89:197-213 pubmed 出版商
图像
图像 1 :
Alomone Labs ACC-017 图像 1
Western blot analysis of rat brain membranes: - 1. Anti-TRPC6 Antibody (#ACC-017), (1:200).2. Anti-TRPC6 Antibody, preincubated with TRPC6 Blocking Peptide (#BLP-CC017).
图像 2 :
Alomone Labs ACC-017 图像 2
Expression of TRPC6 in mouse cerebellum - Immunohistochemical staining of mouse cerebellum using Anti-TRPC6 Antibody (#ACC-017). A. TRPC6 (red) appears in Purkinje cells (arrows) and in the molecular (Mol) layer. B. Staining with mouse anti parvalbumin in the same brain section. C. Confocal merge of TRPC6 and PV demonstrates partial co-localization in the Purkinje and the molecular layers.
图像 3 :
Alomone Labs ACC-017 图像 3
Expression of TRPC6 in human kidney from MN patients - Immunohistochemical staining of human biopsy specimens from MN patients FSGS patients and normal kidney tissue from tumor nephrectomy samples using Anti-TRPC6 Antibody (#ACC-017). TRPC6 expression was below detection levels in control kidneys and only slightly induced in FSGS glomeruli whereas MN kidneys mostly showed moderate to strong positivity for TRPC6.Adapted from Kistler A.D. et al. (2013) J. Biol. Chem. 288 36598. with permission of the American Society for Biochemistry and Molecular Biology.
产品信息
SKU号 :
ACC-017_1_25_mcl
ParentSKU :
ACC-017
Taxonomy Node :
Primary Antibody>Intracellular>Non-Labeled
Action :
Insert
产品名称 :
抗TRPC6抗体
产品描述 :
Anti-TRPC6 Antibody (#ACC-017) is a highly specific antibody directed against an epitope of the mouse protein. The antibody can be used in western blot, immunoprecipitation, indirect flow cytometry, immunohistochemistry, and immunocytochemistry applications. It has been designed to recognize TRPC6 from mouse, rat, and human samples.
Short Description :
A Rabbit Polyclonal Antibody to TRPC6 Channel
Negative Control :
BLP-CC017
同义词 :
TRPC6, Short transient receptor potential channel 6, Transient receptor protein 6, TRP6
靶标名 :
TRPC6 Channel
Primary Category (Old) :
Ion Channels > TRP Channels > TRPC Channels > Antibodies to TRPC Channels
标记/共轭标签 :
未共轭
应用 :
免疫细胞化学, IF, IFC, 免疫组化, 免疫沉淀, 免疫印迹
宿主 :
克隆性 :
多克隆
抗体亚型 :
兔IgG
基因符号 :
TRPC6
反应物种 :
人类(试验);小鼠(试验);大鼠(试验)
同源 :
Rat - identical; human - 15/16 amino acid residues identical.
靶标/背景信息 :
The Transient Receptor Potential (TRP) superfamily is one of the largest ion channel families and consists of diverse groups of proteins. In mammals, about 28 genes encode the TRP ion channel subunits. The mammalian TRP superfamily comprises six subfamilies known as the TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPML (mucolipins), TRPP (polycystin) and the TRPA (ANKTM1) ion channels.1-4 The TRPC subfamily consists of seven proteins named TRPC1 to 7 which can be further divided into four subgroups based on their sequence homology and functional similarities: 1. TRPC1. 2. TRPC4 and TRPC5. 3. TRPC3, TRPC6, TRPC7. 4. TRPC2.2,5 They are highly expressed in the central nervous system and to a lesser extent in peripheral tissues. TRPC6 can form heterotetramers with TRPC3 and TRPC7. It is primarily expressed in brain, lung and muscle. High levels of expression of the channel were also found in human platelets. Recently it was reported that TRPC6 is also expressed in the kidney where a mutated channel has been implicated in kidney failure disease.6,7
免疫原 :
合成肽
区域 :
intracellular
Loop :
Intracellular, N-terminus
序列 :
(C)RRNESQDYLLMDELG, corresponding to amino acid residues 24-38 of mouse TRPC6
序列文本 :
Peptide (C)RRNESQDYLLMDELG, corresponding to amino acid residues 24-38 of mouse TRPC6 (Accession Q61143). Intracellular, N-terminus.
Primary Size (Size+Units) :
1 X 25 mcl
浓度 :
1毫克/毫升
浓度 :
1毫克/毫升
缓冲液 :
磷酸盐缓冲液(PBS)
pH值 :
pH值7.4
防腐剂 :
1% BSA, 0.05% NaN3 (% of reconstituted antibody)
Additive(s) :
Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
格式(液体/冻干) :
冻干粉末
纯化来源(杂交瘤细胞, 腹水 :
Affinity purified on immobilized antigen
储存温度 :
-20°C
UniProt数据库 :
Q61143
Top Related :
ACC-016, ACC-010, ACC-120, ACC-018, ACC-020
储存和重组 :
Reconstitution: 1 X 25 mcl double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C, as long as it is in its original form, it can last a minimum of 3 years this way. The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
包装规格 :
1
产品规格/规格 :
25
单位 :
mcl
标价美国[美元] :
425美元
更多信息或购买 :
公司信息
Alomone Labs
Jerusalem BioPark (JBP), Hadassah Ein Kerem
P.O. Box 4287
Jerusalem 9104201
info@alomone.com
http://www.alomone.com
972-2-587-2202
公司总部: 以色列
Alomone Labs公司成立于1989年,在离子通道、GPCR及神经信号通路研究等领域占据全球领先地位。