抗体

抗IP3受体1(ITPR1)抗体

ACC-019

1 X 25 mcl

425美元

多克隆

domestic rabbit

未共轭

人类, 小鼠, 大鼠

免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀

ACC-019

Primary Antibody>Intracellular>Non-Labeled

Insert

抗IP3受体1(ITPR1)抗体

Anti-IP3 Receptor-1 (ITPR1) Antibody (#ACC-019) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot, immunohistochemistry, and immunocytochemistry applications. It has been designed to recognize IP3R1 from human, rat, and mouse samples.

A兔多克隆抗体IP3 Receptor-1

BLP-CC019

IP3 Receptor-1 (ITPR1), Inositol 1,4,5-trisphosphate receptor type 1, IP3R1, InsP3R1

IP3 Receptor-1

Ion Channels > Intracellular Ion Channels > IP3 Receptor Channels > Antibodies to IP3 Receptors

未共轭

免疫细胞化学, IF, 免疫组化, 免疫沉淀, 免疫印迹

兔

多克隆

兔IgG

ITPR1

人类(试验);小鼠(试验);大鼠(试验)

Human, mouse - identical.

Inositol 1,4,5-triphosphate (IP3) serves as a second messenger for many neurotransmitters, hormones and growth factors.1 The binding of IP3 to its receptor (IP3R), which is a ligand-gated Ca2+ channel, located predominantly at the endoplasmic reticulum, results in a rapid release of Ca2+ from intracellular stores.1 To date, three known isoforms of IP3R are known (designated IP3R1, IP3R2, and IP3R3) that can work as homotetramers or hetrotetramers. All three receptors have six transmembrane domains and a pore region between TM5 and TM6. The N-terminus as well as the C-terminus face the cytoplasm. Each IP3R consists of an N-terminal ligand binding domain (LBD) and a C-terminal domain which is linked by a long regulatory domain. The C-terminus is constitutively active, suggesting that the regulatory domain is required in order to maintain the suppression of channel activity.2 IP3R1 is one of the most important channels responsible for Ca2+ release from intracellular stores and was shown to be the predominant isoform expressed in the central nervous system. IP3R1 is a pivotal player in many neuronal functions, amongst them, neuronal plasticity and neurite extension.3

合成肽

intracellular

Intracellular, C-terminus

(C)RIGLLGHPPHMNVNPQQPA, corresponding to amino acid residues 2732-2750 of rat IP3R1

Peptide (C)RIGLLGHPPHMNVNPQQPA, corresponding to amino acid residues 2732-2750 of rat IP3R1 (Accession P29994). Intracellular, C-terminus.

1 X 25 mcl

0.3毫克/毫升

03毫克/毫升

磷酸盐缓冲液(PBS)

pH值7.4

1% BSA, 0.05% NaN3 (% of reconstituted antibody)

Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.

冻干粉末

IgG fraction purified on immobilized Protein A

-20°C

P29994

ACC-116, ACC-063, ACC-021, ACP-012, ACC-016

Reconstitution: 1 X 25 mcl double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C, as long as it is in its original form, it can last a minimum of 3 years this way. The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

1

25

mcl

425美元