抗体

抗人类趋化因子受体2(细胞外)抗体

ACR-022

1 X 50 mcl

530美元

多克隆

domestic rabbit

未共轭

ACR-022

Primary Antibody>Extracellular>Non-Labeled

Insert

抗人类趋化因子受体2(细胞外)抗体

Anti-Human CCR2 (extracellular) Antibody (#ACR-022) is a highly specific antibody directed against an epitope of the human protein. The antibody can be used in western blot, indirect live cell flow cytometry applications. It has been designed to recognize CCR2 from human samples only. The antibody will not recognize CCR2 from mouse and rat samples.

A兔多克隆抗体趋化因子受体2受体

BLP-CR022

C-趋化因子C受体类型2, 单核细胞趋化蛋白1受体, MCP-1受体, CC-CKR-2, 趋化因子受体2, CD192

趋化因子受体2受体

G-Protein Coupled Receptors > Chemokine Receptors > Antibodies

未共轭

IFC, LCI, 免疫印迹

兔

多克隆

兔IgG

趋化因子受体2

人类(试验)

人类只有

Germline-specific gene 1-like (GSG1L) is a tetra-spanning membrane protein which belongs to the Claudin protein superfamily. It acts as an auxiliary subunit that modulates the assembly, trafficking and gating of AMPA receptors (AMPAR)1. GSG1L has four transmembrane domains, with the N-terminus and the C-terminus in the cytoplasm, the juxtamembrane region in its C-tail extracellular Loop1 domain is critical for its suppression of AMPAR-mediated synaptic transmission2. AMPA receptors are ligand gated ion channels critical for synaptic transmission and plasticity. Their dysfunction is involved in a variety of psychiatric and neurological diseases ranging from major depressive disorder to amyotrophic lateral sclerosis. A newly explored strategy is to manipulate the activity of AMPA receptors is through compounds that affect specific AMPAR-auxiliary subunit complexes. Overexpression of GSG1L strongly suppresses AMPAR, and GSG1L knockout enhances AMPAR-mediated synaptic transmission which makes it a leading therapeutic candidate for manipulating AMPAR activity3.

合成肽

细胞外

细胞外, N末端

RNTNESGEEVTTFFD(C), corresponding to amino acid residues 11-25 of human CCR2

Peptide RNTNESGEEVTTFFD(C), corresponding to amino acid residues 11-25 of human CCR2 (Accession P41597). Extracellular, N-terminus.

1 X 50 mcl

0.8毫克/毫升

08毫克/毫升

磷酸盐缓冲液(PBS)

pH值7.4

1% BSA, 0.05% NaN3 (% of reconstituted antibody)

Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.

冻干粉末

Affinity purified on immobilized antigen

-20°C

P41597

Reconstitution: 1 X 50 mcl double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C, as long as it is in its original form, it can last a minimum of 3 years this way. The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

1

50

mcl

530美元

Cell surface detection of CCR2 in live intact human THP-1 monocytic leukemia cells: Cell surface detection of CCR2 in live intact human THP-1 monocytic leukemia cells: Black line: Cells. Red line: Cells + goat-anti-rabbit-FITC. Green line: Cells + Anti-Human CCR2 (extracellular) Antibody (#ACR-022) (2.5 μg/5x105 cells) + goat-anti-rabbit-FITC.