抗体

抗人类CCR5(细胞外)抗体

ACR-025

1 X 50 mcl

530美元

多克隆

domestic rabbit

未共轭

ACR-025

Primary Antibody>Extracellular>Non-Labeled

Insert

抗人类CCR5(细胞外)抗体

Anti-Human CCR5 (extracellular) Antibody (#ACR-025) is a highly specific antibody directed against an epitope of the human protein. The antibody can be used in western blot analysis. It has been designed to recognize CCR5 from human samples only. The antibody is unlikely to recognize the receptor from mouse and rat samples.

A兔多克隆抗体CCR5趋化因子受体

BLP-CR025

CCR5, C-C chemokine receptor type 5, C-C CKR-5, CHEMR13, HIV-1 fusion coreceptor, CD195

CCR5趋化因子受体

G-Protein Coupled Receptors > Chemokine Receptors > Antibodies

未共轭

IFC, LCI, 免疫印迹

兔

多克隆

兔IgG

CCR5

人类(试验)

人类只有

CCR5 protein is a G-protein coupled receptor (GPCR) responsible for regulating host immune responses and functions against pathogens. The protein plays a key role in transferring immune cells to inflammatory sites and injury. CCR5 is also considered to be an anchor protein for R5-tropic strains of HIV-1 (Human Immunodeficiency Virus-1) to infect immune cells. Thus, CCR5 contributes to the development of AIDS (Acquired Immunodeficiency Syndrome). The receptor is widely expressed in a variety of immune cells involved in the inflammatory responses such as macrophages, monocytes, T cells and dendritic cells1,2. CCR5 is the receptor for the CC ligand 3 (CCL3), CC ligand 4 (CCL4), and CC ligand 5 (CCL5) chemokine ligands. CCR5 and its ligands are upregulated during HIV infection. Studies have shown that lack of homozygosity of CCR5Δ32 variant, a 32 base-pair deletion of the CCR5’s gene coding region, is associated with preventing the risk of HIV-1 infection2,3.

合成肽

细胞外

2nd extracellular loop

CSSHFPYSQYQFWKN, corresponding to amino acid residues 178-192 of human CCR5

Peptide CSSHFPYSQYQFWKN, corresponding to amino acid residues 178-192 of human CCR5 (Accession P51681). 2nd extracellular loop.

1 X 50 mcl

0.8毫克/毫升

08毫克/毫升

磷酸盐缓冲液(PBS)

pH值7.4

1% BSA, 0.05% NaN3 (% of reconstituted antibody)

Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.

冻干粉末

Affinity purified on immobilized antigen

-20°C

P51681

Reconstitution: 1 X 50 mcl double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C, as long as it is in its original form, it can last a minimum of 3 years this way. The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

1

50

mcl

530美元

Cell surface detection of Human CCR5 by indirect flow cytometry in live intact human THP-1 monocytic leukemia cells: Cell surface detection of Human CCR5 by indirect flow cytometry in live intact human THP-1 monocytic leukemia cells: Black line: Cells. Red line: Cells + goat-anti-rabbit-FITC. Green line: Cells +  Anti-Human CCR5 (extracellular) Antibody (#ACR-025), (2.5μg) + goat-anti-rabbit-FITC .