抗体

抗人类CX3C趋化因子受体1(细胞外)抗体

ACR-059

1 X 50 mcl

530美元

多克隆

domestic rabbit

未共轭

ACR-059

Primary Antibody>Extracellular>Non-Labeled

Insert

抗人类CX3C趋化因子受体1(细胞外)抗体

Anti-Human CX3CR1 (extracellular) Antibody (#ACR-059) is a highly specific antibody directed against an epitope of human CX3C chemokine receptor 1. The antibody can be used in western blot and indirect flow cytometry applications. It has been designed to recognize CX3CR1 from human samples only. The antibody will not recognize the protein from rat or mouse samples.

A兔多克隆抗体CX3CR1 Chemokine受体

BLP-CR059

CX3CR1, CX3C chemokine receptor 1, C-X3-C CKR-1, C-X3-C motif chemokine receptor 1, GPR13, CMKBRL1, GPRV28, V28, G-protein coupled receptor 13, CCRL1, Beta chemokine receptor-like 1

CX3CR1 Chemokine受体

G-Protein Coupled Receptors > Chemokine Receptors > Antibodies

未共轭

IFC, LCI, 免疫印迹

兔

多克隆

兔IgG

CX3CL1

人类(试验)

人类只有

CX3C-chemokine receptor 1 (CX3CR1) is a 368 amino acid (aa) protein that contains seven-transmembrane domains and belongs to the family of G protein coupled receptors1. CX3CR1 has a central role in adhesion and chemotaxis through binding to its ligand, fractalkine CX3C chemokine ligand 1, (CX3CL1). The major role of CX3CR1 in immune cells is to recognize and enter inflamed tissue according to CX3CL1 gradient and initiate the innate immune system2. The receptor-ligand axis also mediates the crosstalk between glial cells and neurons by direct or indirect ways in the central nervous system (CNS)3. Expression and interaction of CX3CR1 with CX3CL1 is related to many diseases among which are asthma, cancer and gut infections (reviewed in 4). Both CX3CL1 and CX3CR1 are expressed throughout the body. However, their expression is highly cell type-specific depending on organs and tissues. In the brain, CX3CL1/CX3CR1 signaling can modulate the production of cytokines by microglia cells. It has been reported that CX3CL1/CX3CR1 signaling is associated with Alzheimer's disease5. In the liver, CX3CR1 is expressed in monocytes, CD8+ T cells, and natural killer (NK) cells. Besides immune cells, it is highly expressed at inflammatory sites4.

合成肽

细胞外

细胞外, N末端

(C)ESVTENFEYDDLAE, corresponding to amino acid residues 6-19 of human CX3CR1

Peptide (C)ESVTENFEYDDLAE, corresponding to amino acid residues 6-19 of human CX3CR1 (Accession P49238). Extracellular, N-terminus.

1 X 50 mcl

0.8毫克/毫升

08毫克/毫升

磷酸盐缓冲液(PBS)

pH值7.4

1% BSA, 0.05% NaN3 (% of reconstituted antibody)

Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.

冻干粉末

Affinity purified on immobilized antigen

-20°C

P49238

Reconstitution: 1 X 50 mcl double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C, as long as it is in its original form, it can last a minimum of 3 years this way. The reconstituted solution can be stored at 4°C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 × g 5 min).

1

50

mcl

530美元

Cell surface detection of CX3CR1 in human THP-1 monocytic leukemia cells: Cell surface detection of CX3CR1 in human THP-1 monocytic leukemia cells: Black line: Cells. Red line: Cells + FITC-conjugated goat anti-rabbit antibody. Green line: Cells + Anti-Human CX3CR1 (extracellular) Antibody (#ACR-059) (2.5 µg/5x105 cells) +FITC-conjugated goat anti-rabbit antibody.