产品简要
公司名称 :
Alomone Labs
产品类型 :
抗体
产品名称 :
抗γ-氨基丁酸(A)gamma2受体(细胞外)抗体
目录 :
AGA-005
规格 :
1 X 50 mcl
价格 :
530美元
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学
更多信息或购买 :
文章摘录数: 11
| 出版应用/物种/样本/稀释 | 参考文献 |
|---|---|
| |
图像
图像 1 :
Western blot analysis of rat brain membranes: - 1. Anti-GABA(A) γ2 Receptor (extracellular) Antibody (#AGA-005), (1:200). 2. Anti-GABA(A) γ2 Receptor (extracellular) Antibody, preincubated with GABA(A) γ2 Receptor (extracellular) Blocking Peptide (#BLP-GA005).
产品信息
SKU号 :
AGA-005_1_50_mcl
ParentSKU :
AGA-005
Taxonomy Node :
Primary Antibody>Extracellular>Non-Labeled
Action :
Insert
产品名称 :
抗γ-氨基丁酸(A)gamma2受体(细胞外)抗体
产品描述 :
Anti-GABA(A) γ2 Receptor (extracellular) Antibody (#AGA-005) is a highly specific antibody directed against an epitope of rat GABRG2. The antibody can be used in western blot, immunohistochemistry, and immunocytochemistry applications. The antibody recognizes an extracellular epitope and is thus suited for live cell imaging. It has been designed to recognize GABA(A) γ2 from human, rat, and mouse samples.
Short Description :
A兔多克隆抗体 GABA(A)γ2受体
Negative Control :
BLP-GA005
同义词 :
γ-氨基丁酸(A)gamma2受体, GABRG2, γ-氨基丁酸受体亚单位丙2
Primary Category (Old) :
Ion Channels > Ligand-Gated Ion Channels > GABA(A) Receptors > Antibodies to GABA(A) Receptors
标记/共轭标签 :
未共轭
应用 :
免疫细胞化学, IF, 免疫组化, LCI, 免疫印迹
宿主 :
兔
克隆性 :
多克隆
抗体亚型 :
兔IgG
基因符号 :
GABRG2
反应物种 :
人类(试验);小鼠(试验);大鼠(试验)
同源 :
Human, mouse, bovine - identical; chick - 13/15 amino acid residues identical.
靶标/背景信息 :
The neurotransmitter GABA (γ-aminobutyric acid) inhibits the activity of signal-receiving neurons by interacting with the GABAA receptor on these cells.1 There are two major types of GABA receptors: the ionotropic GABAA (GABAA R) and the metabotropic GABAB receptors.
GABAA R belongs to the ligand gated ion channel superfamily.1,2
It is a heteropentamer, with all of its five subunits contributing to the pore formation. To date, eight subunit isoforms were cloned: α, β, γ, δ, ε, π, θ, and ρ.1
The native GABAA receptor, in most cases, consists of 2α, 2β and 1γ subunit. Three γ subunits genes have been identified in mammals.
The binding of GABA to its GABAA receptor results in conformational changes that open a Cl- channel, producing an increase in membrane conductance, resulting in inhibition of neural activity.2,3
Recently, a genetic linkage between familial epilepsy syndrome and mutations in the γ2 subunit of the GABAA receptor have been demonstrated.4,5
免疫原 :
合成肽
区域 :
细胞外
Loop :
细胞外, N末端
序列 :
QKSDDDYEDYASNKT(C), corresponding to amino acid residues 39-53 of rat GABA(A) γ2 receptor
序列文本 :
Peptide QKSDDDYEDYASNKT(C), corresponding to amino acid residues 39-53 of rat GABA(A) γ2 receptor (Accession P18508). Extracellular, N-terminus.
Primary Size (Size+Units) :
1 X 50 mcl
浓度 :
0.8毫克/毫升
浓度 :
08毫克/毫升
缓冲液 :
磷酸盐缓冲液(PBS)
pH值 :
pH值7.4
防腐剂 :
1% BSA, 0.05% NaN3 (% of reconstituted antibody)
Additive(s) :
Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
格式(液体/冻干) :
冻干粉末
纯化来源(杂交瘤细胞, 腹水 :
Affinity purified on immobilized antigen
储存温度 :
-20°C
UniProt数据库 :
P18508
Top Related :
AGA-001, AGA-002, AGA-003, AGC-004, AGC-001
储存和重组 :
Reconstitution: 1 X 50 mcl double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C, as long as it is in its original form, it can last a minimum of 3 years this way. The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
包装规格 :
1
产品规格/规格 :
50
单位 :
mcl
标价美国[美元] :
530美元
更多信息或购买 :
公司信息
Alomone Labs
Jerusalem BioPark (JBP), Hadassah Ein Kerem
P.O. Box 4287
Jerusalem 9104201
P.O. Box 4287
Jerusalem 9104201
info@alomone.com
http://www.alomone.com972-2-587-2202
公司总部: 以色列
Alomone Labs公司成立于1989年，在离子通道、GPCR及神经信号通路研究等领域占据全球领先地位。